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UniProtKB/Swiss-Prot entry Q8J130


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYRO_ASPFU
Primary accession number Q8J130
Secondary accession number Q4WR60
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on January 10, 2006 (Sequence version 2)
Annotations were last modified on    November 4, 2008 (Entry version 33)
Name and origin of the protein
Protein name Tyrosinase
Synonyms EC 1.14.18.1
Monophenol monooxygenase
Gene name
Name: tyr1
ORFNames: AFUA_1G17430
From
Aspergillus fumigatus (Sartorya fumigata) [TaxID: 5085] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; mitosporic Trichocomaceae; Aspergillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 46645 / NCPF 2109;
Langfelder K., Glaser P., Brakhage A.A.;
"Cloning of a tyrosinase gene of the human pathogenic fungus Aspergillus fumigatus.";
Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Af293 / CBS 101355 / FGSC A1100;
DOI=10.1038/nature04332; PubMed=16372009 [NCBI, ExPASy, EBI, Israel, Japan]
Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W.;
"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus.";
Nature 438:1151-1156(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ293806; CAC82195.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAHF01000004; EAL91072.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_753110.1; -.
3D structure databases
ModBase Q8J130.
Ontologies
GO
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004503; Molecular function: monophenol monooxygenase activity (inferred from electronic annotation from EC).
GO:0006583; Biological process: melanin biosynthetic process from tyrosine (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR008922; Di-copper_centre.
IPR016216; Monophenol_mOase_fun.
IPR002227; Tyrosinase.
Graphical view of domain structure.
Gene3D G3DSA:1.10.1280.10; Di-copper_centre; 1.
Pfam PF00264; Tyrosinase; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000340; MPO_fungal; 1.
PRINTS PR00092; TYROSINASE.
PROSITE PS00497; TYROSINASE_1; 1.
PS00498; TYROSINASE_2; 1.
ProtoNet Q8J130.
Genome annotation databases
GeneID 3510142; -.
KEGG afm:AFUA_1G17430; -.
Phylogenomic databases
HOGENOM Q8J130; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Copper; Melanin biosynthesis; Metal-binding; Monooxygenase; Oxidoreductase; Thioether bond.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   630  630     Tyrosinase. PRO_0000186732
METAL   69    69        Copper A (By similarity). 
METAL   92    92        Copper A (By similarity). 
METAL   101   101        Copper A (By similarity). 
METAL   317   317        Copper B (By similarity). 
METAL   321   321        Copper B (By similarity). 
METAL   360   360        Copper B (By similarity). 
CROSSLNK   90    92        2'-(S-cysteinyl)-histidine (Cys-His) (By similarity). 
CONFLICT   322   335        Missing (in Ref. 2; EAL91072). 
CONFLICT   600   600        E -> D (in Ref. 1; CAC82195). 
Sequence information
Length: 630 AA [This is the length of the unprocessed precursor] Molecular weight: 73032 Da [This is the MW of the unprocessed precursor] CRC64: 11A769BD9737BF35 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSSNKPYVIK GIPVDAGQII PVRRDIDEWY EDTSRQSRIQ LSIFIWALRE FQSIDYKDRL 

        70         80         90        100        110        120 
SYFQIAGIHH FPLITWDEEE PPVPNKPGYC VHNNVTFPTW HRPYMLLFEQ RLFEIMETTI 

       130        140        150        160        170        180 
KETVPESHKQ EWRDAARQWR LPYWDFAKTS GPHATGPLSL PVLCGLANVV ILNPANPETP 

       190        200        210        220        230        240 
IELPNPVYKY RAPDLMGNLD KPFHIPPERI DPDKDDYYPW DKCQATTKYG LLKNNPHIQD 

       250        260        270        280        290        300 
AGQDVTKSNL ALNEHPWYRP NKAGFPPLQT LTYEVHRLLS FKFSSWGAFA STKWCNEENK 

       310        320        330        340        350        360 
PPASQQTRDI LSLEYIHNNV HNWVGGTDYL GDPSKPDLQG AGHMSSVPVA AFDPIFWLYH 

       370        380        390        400        410        420 
NNVDRLTAIW QVLNQDHWFD EPHPSDAKPD DPLKPFHVSK DKYFTSDDAR FWRKYGYDYD 

       430        440        450        460        470        480 
IVKKPGTNED RAPEEVKMKI NQLYGEPISR LHEGQPVEYD YVINVIYDRY ALDGIPYTIV 

       490        500        510        520        530        540 
FYLHLKDGSY KCLGGVYTFS TKLSDAQDTE RGGCDNCREQ KKAGVLASAQ IPLTYTLYER 

       550        560        570        580        590        600 
QEWHNLGKLL PVKETADIIR QHLCWKVVGV NNSILFDSEQ PMRGDPATWR SLDVTAAYSE 

       610        620        630 
IHYPVDRNYK YIDRGLPAYH NYLPIHLSPT 

Q8J130 in FASTA format

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