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UniProtKB/Swiss-Prot entry Q8IZJ1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name UNC5B_HUMAN
Primary accession number Q8IZJ1
Secondary accession numbers Q86SN3 Q8N1Y2 Q9H9F3
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 62)
Name and origin of the protein
Protein name Netrin receptor UNC5B [Precursor]
Synonyms Protein unc-5 homolog B
Unc-5 homolog 2
p53-regulated receptor for death and life protein 1
Gene name
Name: UNC5B
Synonyms: P53RDL1, UNC5H2
ORFNames: UNQ1883/PRO4326
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND INTERACTION WITH GNAI2.
TISSUE=Lung;
DOI=10.1016/S0006-291X(02)02277-5; PubMed=12359238 [NCBI, ExPASy, EBI, Israel, Japan]
Komatsuzaki K., Dalvin S., Kinane T.B.;
"Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2.";
Biochem. Biophys. Res. Commun. 297:898-905(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, AND MUTAGENESIS OF ASP-412.
DOI=10.1038/ncb943; PubMed=12598906 [NCBI, ExPASy, EBI, Israel, Japan]
Tanikawa C., Matsuda K., Fukuda S., Nakamura Y., Arakawa H.;
"p53RDL1 regulates of p53-dependent apoptosis.";
Nat. Cell Biol. 5:216-223(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 361-945.
TISSUE=Amygdala, and Teratocarcinoma;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
DOWN-REGULATION IN CANCER.
DOI=10.1073/pnas.0738063100; PubMed=12655055 [NCBI, ExPASy, EBI, Israel, Japan]
Thiebault K., Mazelin L., Pays L., Llambi F., Joly M.-O., Scoazec J.-Y., Saurin J.-C., Romeo G., Mehlen P.;
"The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.";
Proc. Natl. Acad. Sci. U.S.A. 100:4173-4178(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY126437; AAM95701.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB096256; BAC57998.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358351; AAQ88717.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK022859; BAB14276.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK094595; BAC04382.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00328431; -.
IPI00383609; -.
RefSeq NP_734465.2; -.
UniGene Hs.522997
3D structure databases
HSSP P07996; 1LSL. [HSSP ENTRY / PDB]
SMR Q8IZJ1; 854-943.
ModBase Q8IZJ1.
PTM databases
PhosphoSite Q8IZJ1; -.
Organism-specific databases
GeneCards GC10P072642; -.
H-InvDB HIX0008901; -.
HGNC HGNC:12568; UNC5B.
GenAtlas UNC5B.
HPA HPA011141; -.
MIM 607870; gene. [NCBI / EBI]
PharmGKB PA37205; -.
Gene expression databases
ArrayExpress Q8IZJ1; -.
Bgee Q8IZJ1; -.
CleanEx HS_UNC5B; -.
GermOnline ENSG00000107731; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0004872; Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006915; Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000488; Death.
IPR011029; DEATH-like.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR000884; Thrombospondin_1_rpt.
IPR008085; Thrombospondin_1_rpt_sub.
IPR000906; ZU5.
Graphical view of domain structure.
Gene3D G3DSA:1.10.533.10; DEATH_like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF00531; Death; 1.
PF07679; I-set; 1.
PF00090; TSP_1; 2.
PF00791; ZU5; 1.
Pfam graphical view of domain structure.
PRINTS PR01705; TSP1REPEAT.
SMART SM00005; DEATH; 1.
SM00408; IGc2; 1.
SM00209; TSP1; 2.
SM00218; ZU5; 1.
SMART graphical view of domain structure.
PROSITE PS50017; DEATH_DOMAIN; FALSE_NEG.
PS50835; IG_LIKE; 1.
PS50092; TSP1; 2.
PS51145; ZU5; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q8IZJ1; -.
Genome annotation databases
Ensembl ENSG00000107731; Homo sapiens. [Contig view]
GeneID 219699; -.
KEGG hsa:219699; -.
Phylogenomic databases
HOGENOM Q8IZJ1; -.
HOVERGEN Q8IZJ1; -.
OMA Q8IZJ1; YLRKNFD.
Other
NextBio 90721; -.
PMAP-CutDB Q8IZJ1; -.
SOURCE UNC5B; Homo sapiens.
ProtoNet Q8IZJ1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Apoptosis; Developmental protein; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    26  26     Potential. 
CHAIN   27   945  919     Netrin receptor UNC5B. PRO_0000036071
TOPO_DOM   27   377  351     Extracellular (Potential). 
TRANSMEM   378   398  21     Potential. 
TOPO_DOM   399   945  547     Cytoplasmic (Potential). 
DOMAIN   48   145  98     Ig-like. 
DOMAIN   147   242  96     Ig-like C2-type. 
DOMAIN   246   300  55     TSP type-1 1. 
DOMAIN   302   354  53     TSP type-1 2. 
DOMAIN   541   647  107     ZU5. 
DOMAIN   865   943  79     Death. 
REGION   707   725  19     Interaction with DCC (By similarity). 
SITE   412   413  2     Cleavage; by caspase-3. 
CARBOHYD   222   222        N-linked (GlcNAc...) (Potential). 
CARBOHYD   347   347        N-linked (GlcNAc...) (Potential). 
DISULFID   69   128        By similarity. 
DISULFID   174   225        By similarity. 
DISULFID   258   295        By similarity. 
DISULFID   262   299        By similarity. 
DISULFID   273   285        By similarity. 
VAR_SEQ   356   367        NKKTLSDPNSHL -> M (in isoform 2). VSP_011698
VARIANT   242   242  1     I -> V (in dbSNP:rs34957097 [NCBI]). VAR_052472 
VARIANT   516   516  1     A -> T (in dbSNP:rs10509332 [NCBI]). VAR_019730 
MUTAGEN   412   412        D->N: Abolishes cleavage by caspase-3 and subsequent induction of apoptosis. 
CONFLICT   483   483        K -> E (in Ref. 3; BAC04382). 
CONFLICT   851   851        L -> P (in Ref. 3; BAB14276). 
Sequence information
Length: 945 AA [This is the length of the unprocessed precursor] Molecular weight: 103638 Da [This is the MW of the unprocessed precursor] CRC64: 56064E335F323447 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGARSGARGA LLLALLLCWD PRLSQAGTDS GSEVLPDSFP SAPAEPLPYF LQEPQDAYIV 

        70         80         90        100        110        120 
KNKPVELRCR AFPATQIYFK CNGEWVSQND HVTQEGLDEA TGLRVREVQI EVSRQQVEEL 

       130        140        150        160        170        180 
FGLEDYWCQC VAWSSAGTTK SRRAYVRIAY LRKNFDQEPL GKEVPLDHEV LLQCRPPEGV 

       190        200        210        220        230        240 
PVAEVEWLKN EDVIDPTQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT 

       250        260        270        280        290        300 
VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTICP 

       310        320        330        340        350        360 
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCMQNKKTL 

       370        380        390        400        410        420 
SDPNSHLLEA SGDAALYAGL VVAIFVVVAI LMAVGVVVYR RNCRDFDTDI TDSSAALTGG 

       430        440        450        460        470        480 
FHPVNFKTAR PSNPQLLHPS VPPDLTASAG IYRGPVYALQ DSTDKIPMTN SPLLDPLPSL 

       490        500        510        520        530        540 
KVKVYSSSTT GSGPGLADGA DLLGVLPPGT YPSDFARDTH FLHLRSASLG SQQLLGLPRD 

       550        560        570        580        590        600 
PGSSVSGTFG CLGGRLSIPG TGVSLLVPNG AIPQGKFYEM YLLINKAEST LPLSEGTQTV 

       610        620        630        640        650        660 
LSPSVTCGPT GLLLCRPVIL TMPHCAEVSA RDWIFQLKTQ AHQGHWEEVV TLDEETLNTP 

       670        680        690        700        710        720 
CYCQLEPRAC HILLDQLGTY VFTGESYSRS AVKRLQLAVF APALCTSLEY SLRVYCLEDT 

       730        740        750        760        770        780 
PVALKEVLEL ERTLGGYLVE EPKPLMFKDS YHNLRLSLHD LPHAHWRSKL LAKYQEIPFY 

       790        800        810        820        830        840 
HIWSGSQKAL HCTFTLERHS LASTELTCKI CVRQVEGEGQ IFQLHTTLAE TPAGSLDTLC 

       850        860        870        880        890        900 
SAPGSTVTTQ LGPYAFKIPL SIRQKICNSL DAPNSRGNDW RMLAQKLSMD RYLNYFATKA 

       910        920        930        940 
SPTGVILDLW EALQQDDGDL NSLASALEEM GKSEMLVAVA TDGDC 

Q8IZJ1 in FASTA format

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