[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). TISSUE=Spleen; Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.; "The nucleotide sequence of a long cDNA clone isolated from human spleen."; Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). TISSUE=Lymph, Skin, and Uterus; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

INTERACTION:
Q9BRP4:WDR71; NbExp=1; IntAct=EBI-1044483, EBI-1056358;

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	Q8IZ83-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q8IZ83-2
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_029982, VSP_029983.

SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CAUTION: The active site cysteine and glutamate residues are not conserved in this protein. Its activity is therefore unsure.
SEQUENCE CAUTION:
- Sequence=BAB84962.1; Type=Erroneous translation; Note=Wrong choice of frame

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AK074136; BAB84962.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC014895; AAH14895.2; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC035641; AAH35641.1; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC042142; AAH42142.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_699160.1; -.

UniGene

Hs.355398

3D structure databases

ModBase

Q8IZ83.

Protein-protein interaction databases

IntAct

Q8IZ83; -.

Organism-specific databases

HGNC

HGNC:28114; ALDH16A1.

PA134903503; -.

Gene expression databases

ArrayExpress

Q8IZ83; -.

CleanEx

HS_ALDH16A1; -.

Ontologies

GO:0005515;	Molecular function: protein binding (inferred from physical interaction from IntAct).
QuickGo view.

Family and domain databases

InterPro

IPR011408; ADH_dupl.
IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 2.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 2.
Pfam graphical view of domain structure.

PIRSF

PIRSF036490; Aldedh_dupl; 1.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; FALSE_NEG.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.

BLOCKS

Q8IZ83.

Genome annotation databases

Ensembl

ENSG00000161618; Homo sapiens. [Contig view]

GeneID

126133; -.

KEGG

hsa:126133; -.

Phylogenomic databases

HOGENOM

Q8IZ83; -.

HOVERGEN

Q8IZ83; -.

Other

ProtoNet

Q8IZ83.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Polymorphism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 802`	`802`	`Aldehyde dehydrogenase family 16 member A1.`	`PRO_0000312986`
`VAR_SEQ`	`254 308`		`EGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEG` `VVDAAWSDRGPGGLR -> VPSGQGSWRNAAGGRKAPPAAELGGVPRKGVPFDGAWRES` `VRSWAWRWGRSRCCC (in isoform 2).`	`VSP_029982`
`VAR_SEQ`	`309 802`		`Missing (in isoform 2).`	`VSP_029983`
`VARIANT`	`110 110`	`1`	`E -> K (in dbSNP:rs3745312 [NCBI]).`	`VAR_037638`
`VARIANT`	`227 227`	`1`	`V -> L (in dbSNP:rs1320303 [NCBI]).`	`VAR_037639`

Sequence information

Length: 802 AA [This is the length of the unprocessed precursor]

Molecular weight: 85113 Da [This is the MW of the unprocessed precursor]

CRC64: E2DD75662DFEB827 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAATRAGPRA REIFTSLEYG PVPESHACAL AWLDTQDRCL GHYVNGKWLK PEHRNSVPCQ 

        70         80         90        100        110        120 
DPITGENLAS CLQAQAEDVA AAVEAARMAF KGWSAHPGVV RAQHLTRLAE VIQKHQRLLW 

       130        140        150        160        170        180 
TLESLVTGRA VREVRDGDVQ LAQQLLHYHA IQASTQEEAL AGWEPMGVIG LILPPTFSFL 

       190        200        210        220        230        240 
EMMWRICPAL AVGCTVVALV PPASPAPLLL AQLAGELGPF PGILNVVSGP ASLVPILASQ 

       250        260        270        280        290        300 
PGIRKVAFCG APEEGRALRR SLAGECAELG LALGTESLLL LTDTADVDSA VEGVVDAAWS 

       310        320        330        340        350        360 
DRGPGGLRLL IQESVWDEAM RRLQERMGRL RSGRGLDGAV DMGARGAAAC DLVQRFVREA 

       370        380        390        400        410        420 
QSQGAQVFQA GDVPSERPFY PPTLVSNLPP ASPCAQVEVP WPVVVASPFR TAKEALLVAN 

       430        440        450        460        470        480 
GTPRGGSASV WSERLGQALE LGYGLQVGTV WINAHGLRDP SVPTGGCKES GCSWHGGPDG 

       490        500        510        520        530        540 
LYEYLRPSGT PARLSCLSKN LNYDTFGLAV PSTLPAGPEI GPSPAPPYGL FVGGRFQAPG 

       550        560        570        580        590        600 
ARSSRPIRDS SGNLHGYVAE GGAKDIRGAV EAAHQAFPGW AGQSPGARAA LLWALAAALE 

       610        620        630        640        650        660 
RRKSTLASRL ERQGAELKAA EAEVELSARR LRAWGARVQA QGHTLQVAGL RGPVLRLREP 

       670        680        690        700        710        720 
LGVLAVVCPD EWPLLAFVSL LAPALAYGNT VVMVPSAACP LLALEVCQDM ATVFPAGLAN 

       730        740        750        760        770        780 
VVTGDRDHLT RCLALHQDVQ AMWYFGSAQG SQFVEWASAG NLKPVWASRG CPRAWDQEAE 

       790        800 
GAGPELGLRV ARTKALWLPM GD

Q8IZ83 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools