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UniProtKB/Swiss-Prot entry Q8IXB1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DJC10_HUMAN
Primary accession number Q8IXB1
Secondary accession numbers Q17RJ6 Q4ZG06 Q53QT7 Q6UWZ6 Q86T61 Q8NC82 Q8TD87 Q96K38 Q96K44 Q96K54 Q9NSY6
Integrated into Swiss-Prot on April 3, 2007
Sequence was last modified on April 3, 2007 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 56)
Name and origin of the protein
Protein name DnaJ homolog subfamily C member 10 [Precursor]
Synonyms ER-resident protein ERdj5
Macrothioredoxin
MTHr
Gene name
Name: DNAJC10
Synonyms: ERDJ5
ORFNames: UNQ495/PRO1012
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH HSPA5.
DOI=10.1074/jbc.M206995200; PubMed=12411443 [NCBI, ExPASy, EBI, Israel, Japan]
Cunnea P.M., Miranda-Vizuete A., Bertoli G., Simmen T., Damdimopoulos A.E., Hermann S., Leinonen S., Huikko M.P., Gustafsson J.-A., Sitia R., Spyrou G.;
"ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.";
J. Biol. Chem. 278:1059-1066(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT ASN-76.
TISSUE=Fetal brain;
DOI=10.1023/A:1025510502147; PubMed=14587667 [NCBI, ExPASy, EBI, Israel, Japan]
Gu S.-H., Chen J.-Z., Ying K., Wang S., Jin W., Qian J., Zhao E.-P., Xie Y., Mao Y.-M.;
"Cloning and identification of a novel cDNA which encodes a putative protein with a DnaJ domain and a thioredoxin active motif, human macrothioredoxin.";
Biochem. Genet. 41:245-253(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLN-646.
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-646.
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-793 (ISOFORM 1), AND VARIANTS ASN-76 AND GLN-646.
TISSUE=Spinal cord, and Testis;
DOI=10.1186/1471-2164-8-399; PubMed=17974005 [NCBI, ExPASy, EBI, Israel, Japan]
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 414-793.
TISSUE=Teratocarcinoma;
DOI=10.1093/dnares/12.2.117; PubMed=16303743 [NCBI, ExPASy, EBI, Israel, Japan]
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y., Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.;
"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.";
DNA Res. 12:117-126(2005).
[9]
IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J., Superti-Furga G., Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF038503; AAN73271.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF490904; AAM09527.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358577; AAQ88940.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027450; BAB55121.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027647; BAB55263.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK027696; BAB55304.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC073951; AAX88931.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC105396; AAY24240.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117299; AAI17300.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC126168; AAI26169.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL137648; CAB70858.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL832646; CAD89982.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK074905; BAC11281.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00293260; -.
IPI00844115; -.
PIR T46333; T46333.
RefSeq NP_061854.1; -.
UniGene Hs.516632
3D structure databases
HSSP P08622; 1BQZ. [HSSP ENTRY / PDB]
ModBase Q8IXB1.
Organism-specific databases
GeneCards GC02P183289; -.
HGNC HGNC:24637; DNAJC10.
GenAtlas DNAJC10.
MIM 607987; gene. [NCBI / EBI]
PharmGKB PA134917195; -.
Gene expression databases
ArrayExpress Q8IXB1; -.
Bgee Q8IXB1; -.
Ontologies
GO
GO:0005783; Cellular component: endoplasmic reticulum (inferred from electronic annotation from UniProtKB-KW).
GO:0005788; Cellular component: endoplasmic reticulum lumen (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-SubCell).
GO:0031072; Molecular function: heat shock protein binding (inferred from electronic annotation from InterPro).
GO:0051082; Molecular function: unfolded protein binding (inferred from electronic annotation from InterPro).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0006457; Biological process: protein folding (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001623; DnaJ_N.
IPR000886; ER_targeting_sequence.
IPR018253; Heat_shock_DnaJ_CS.
IPR015609; Hsp40/DnaJ_Rel.
IPR003095; Hsp_DnaJ.
IPR017936; Thioredoxin-like.
IPR017937; Thioredoxin_CS.
IPR013766; Thioredoxin_domain.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:1.10.287.110; DnaJ_N; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 4.
PANTHER PTHR11821; Hsp40/DnaJ_Rel; 1.
Pfam PF00226; DnaJ; 1.
PF00085; Thioredoxin; 4.
Pfam graphical view of domain structure.
PRINTS PR00625; DNAJPROTEIN.
SMART SM00271; DnaJ; 1.
SMART graphical view of domain structure.
PROSITE PS00636; DNAJ_1; FALSE_NEG.
PS50076; DNAJ_2; 1.
PS00014; ER_TARGET; 1.
PS00194; THIOREDOXIN_1; 2.
PS51352; THIOREDOXIN_2; 3.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q8IXB1; -.
Genome annotation databases
Ensembl ENSG00000077232; Homo sapiens. [Contig view]
GeneID 54431; -.
KEGG hsa:54431; -.
NMPDR fig|9606.3.peg.19011; -.
Phylogenomic databases
HOVERGEN Q8IXB1; -.
OMA Q8IXB1; PELRKAS.
Other
NextBio 56629; -.
SOURCE DNAJC10; Homo sapiens.
ProtoNet Q8IXB1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Chaperone; Endoplasmic reticulum; Glycoprotein; Polymorphism; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    32  32     Potential. 
CHAIN   33   793  761     DnaJ homolog subfamily C member 10. PRO_0000281483
DOMAIN   35   100  66     J. 
DOMAIN   130   232  103     Thioredoxin 1. 
DOMAIN   454   553  100     Thioredoxin 2. 
DOMAIN   557   662  106     Thioredoxin 3. 
DOMAIN   671   778  108     Thioredoxin 4. 
MOTIF   790   793  4     Prevents secretion from ER (Potential). 
CARBOHYD   530   530        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   284   329        Missing (in isoform 2). VSP_024011
VARIANT   76    76  1     D -> N (in dbSNP:rs6729801 [NCBI]). VAR_031247 
VARIANT   347   347  1     L -> I (in dbSNP:rs13414223 [NCBI]). VAR_048912 
VARIANT   414   414  1     Y -> C (in dbSNP:rs11681366 [NCBI]). VAR_031248 
VARIANT   646   646  1     H -> Q (in dbSNP:rs288334 [NCBI]). VAR_031249 
CONFLICT   5     5        L -> S (in Ref. 2; AAM09527 and 4; BAB55304). 
CONFLICT   213   213        P -> A (in Ref. 1; AAN73271). 
CONFLICT   356   359        NTLE -> KRVK (in Ref. 1; AAN73271). 
CONFLICT   446   446        F -> S (in Ref. 4; BAB55121). 
CONFLICT   565   565        T -> A (in Ref. 7; CAD89982). 
CONFLICT   633   633        E -> K (in Ref. 7; CAB70858). 
CONFLICT   755   755        K -> N (in Ref. 4; BAB55304). 
CONFLICT   771   771        I -> T (in Ref. 7; CAD89982). 
Sequence information
Length: 793 AA [This is the length of the unprocessed precursor] Molecular weight: 91080 Da [This is the MW of the unprocessed precursor] CRC64: BD39B64325432D5D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGVWLNKDDY IRDLKRIILC FLIVYMAILV GTDQDFYSLL GVSKTASSRE IRQAFKKLAL 

        70         80         90        100        110        120 
KLHPDKNPNN PNAHGDFLKI NRAYEVLKDE DLRKKYDKYG EKGLEDNQGG QYESWNYYRY 

       130        140        150        160        170        180 
DFGIYDDDPE IITLERREFD AAVNSGELWF VNFYSPGCSH CHDLAPTWRD FAKEVDGLLR 

       190        200        210        220        230        240 
IGAVNCGDDR MLCRMKGVNS YPSLFIFRSG MAPVKYHGDR SKESLVSFAM QHVRSTVTEL 

       250        260        270        280        290        300 
WTGNFVNSIQ TAFAAGIGWL ITFCSKGGDC LTSQTRLRLS GMLDGLVNVG WMDCATQDNL 

       310        320        330        340        350        360 
CKSLDITTST TAYFPPGATL NNKEKNSILF LNSLDAKEIY LEVIHNLPDF ELLSANTLED 

       370        380        390        400        410        420 
RLAHHRWLLF FHFGKNENSN DPELKKLKTL LKNDHIQVGR FDCSSAPDIC SNLYVFQPSL 

       430        440        450        460        470        480 
AVFKGQGTKE YEIHHGKKIL YDILAFAKES VNSHVTTLGP QNFPANDKEP WLVDFFAPWC 

       490        500        510        520        530        540 
PPCRALLPEL RRASNLLYGQ LKFGTLDCTV HEGLCNMYNI QAYPTTVVFN QSNIHEYEGH 

       550        560        570        580        590        600 
HSAEQILEFI EDLMNPSVVS LTPTTFNELV TQRKHNEVWM VDFYSPWCHP CQVLMPEWKR 

       610        620        630        640        650        660 
MARTLTGLIN VGSIDCQQYH SFCAQENVQR YPEIRFFPPK SNKAYHYHSY NGWNRDAYSL 

       670        680        690        700        710        720 
RIWGLGFLPQ VSTDLTPQTF SEKVLQGKNH WVIDFYAPWC GPCQNFAPEF ELLARMIKGK 

       730        740        750        760        770        780 
VKAGKVDCQA YAQTCQKAGI RAYPTVKFYF YERAKRNFQE EQINTRDAKA IAALISEKLE 

       790 
TLRNQGKRNK DEL 

Q8IXB1 in FASTA format

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