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UniProtKB/Swiss-Prot entry Q8IW75

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SPA12_HUMAN
Primary accession number Q8IW75
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 45)
Name and origin of the protein
Protein name Serpin A12 [Precursor]
Synonyms Visceral adipose tissue-derived serine protease inhibitor
Vaspin
Visceral adipose-specific serpin
OL-64
Gene name
Name: SERPINA12
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
DOI=10.1073/pnas.0504703102; PubMed=16030142 [NCBI, ExPASy, EBI, Israel, Japan]
Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K., Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S., Makino H., Kanwar Y.S.;
"Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity.";
Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
Chen S., Guo J.H., Yu L.;
Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY326420; AAP88384.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY177692; AAO18649.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC040857; AAH40857.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_776249.1; -.
UniGene Hs.99476
3D structure databases
HSSP P01009; 1QMB. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q8IW75.
Protein family/group databases
MEROPS I04.965; -.
Organism-specific databases
H-InvDB HIX0026658; -.
HGNC HGNC:18359; SERPINA12.
GenAtlas SERPINA12.
PharmGKB PA134863157; -.
GeneCards Q8IW75.
Gene expression databases
ArrayExpress Q8IW75; -.
CleanEx HS_SERPINA12; -.
GermOnline ENSG00000165953; Homo sapiens.
Family and domain databases
InterPro IPR000215; Protease_inhib_I4_serpin.
Graphical view of domain structure.
PANTHER PTHR11461; Prot_inh_serpin; 1.
Pfam PF00079; Serpin; 1.
Pfam graphical view of domain structure.
SMART SM00093; SERPIN; 1.
SMART graphical view of domain structure.
PROSITE PS00284; SERPIN; FALSE_NEG.
BLOCKS Q8IW75.
Genome annotation databases
Ensembl ENSG00000165953; Homo sapiens. [Contig view]
GeneID 145264; -.
KEGG hsa:145264; -.
Phylogenomic databases
HOGENOM Q8IW75; -.
HOVERGEN Q8IW75; -.
Other
ProtoNet Q8IW75.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Protease inhibitor; Secreted; Serine protease inhibitor; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     By similarity. 
CHAIN   21   414  394     Serpin A12. PRO_0000041976
CARBOHYD   221   221        N-linked (GlcNAc...) (Potential). 
CARBOHYD   233   233        N-linked (GlcNAc...) (Potential). 
CARBOHYD   267   267        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 414 AA [This is the length of the unprocessed precursor] Molecular weight: 47175 Da [This is the MW of the unprocessed precursor] CRC64: 5C70F1AB5935661C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNPTLGLAIF LAVLLTVKGL LKPSFSPRNY KALSEVQGWK QRMAAKELAR QNMDLGFKLL 

        70         80         90        100        110        120 
KKLAFYNPGR NIFLSPLSIS TAFSMLCLGA QDSTLDEIKQ GFNFRKMPEK DLHEGFHYII 

       130        140        150        160        170        180 
HELTQKTQDL KLSIGNTLFI DQRLQPQRKF LEDAKNFYSA ETILTNFQNL EMAQKQINDF 

       190        200        210        220        230        240 
ISQKTHGKIN NLIENIDPGT VMLLANYIFF RARWKHEFDP NVTKEEDFFL EKNSSVKVPM 

       250        260        270        280        290        300 
MFRSGIYQVG YDDKLSCTIL EIPYQKNITA IFILPDEGKL KHLEKGLQVD TFSRWKTLLS 

       310        320        330        340        350        360 
RRVVDVSVPR LHMTGTFDLK KTLSYIGVSK IFEEHGDLTK IAPHRSLKVG EAVHKAELKM 

       370        380        390        400        410 
DERGTEGAAG TGAQTLPMET PLVVKIDKPY LLLIYSEKIP SVLFLGKIVN PIGK
Q8IW75 in FASTA format

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