[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May be involved in sphingolipid synthesis or its regulation (By similarity).
SUBCELLULAR LOCATION: Nucleus membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Contains 1 homeobox DNA-binding domain.
SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC028703; AAH28703.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034500; AAH34500.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034970; AAH34970.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI00216667; -.

NP_849164.2; -.

3D structure databases

ModBase

Q8IU89.

Organism-specific databases

GC15M098758; -.

HGNC:23752; LASS3.

HPA006092; -.

PA134873153; -.

Gene expression databases

Q8IU89; -.

Q8IU89; -.

HS_LASS3; -.

ENSG00000154227; Homo sapiens.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0031965;	Cellular component: nuclear membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0043565;	Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700;	Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0006355;	Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR001356; Homeobox.
IPR017970; Homeobox_CS.
IPR016439; Longevity_assurance_LAG1_LAC1.
IPR006634; TLC.
Graphical view of domain structure.

Pfam

PF00046; Homeobox; 1.
PF03798; TRAM_LAG1_CLN8; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF005225; LAG1_LAC1; 1.

SMART

SM00389; HOX; 1.
SM00724; TLC; 1.
SMART graphical view of domain structure.

PROSITE

PS00027; HOMEOBOX_1; FALSE_NEG.
PS50071; HOMEOBOX_2; 1.
PS50922; TLC; 1.
PROSITE graphical view of domain structure (profiles).

Proteomic databases

PRIDE

Q8IU89; -.

Genome annotation databases

Ensembl

ENSG00000154227; Homo sapiens. [Contig view]

GeneID

204219; -.

KEGG

hsa:204219; -.

Phylogenomic databases

HOGENOM

Q8IU89; -.

HOVERGEN

Q8IU89; -.

Other

90468; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

DNA-binding; Homeobox; Lipid synthesis; Membrane; Nucleus; Polymorphism; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 383`	`383`	`LAG1 longevity assurance homolog 3.`	`PRO_0000185511`
`TRANSMEM`	`32 52`	`21`	`Potential.`
`TRANSMEM`	`139 159`	`21`	`Potential.`
`TRANSMEM`	`174 194`	`21`	`Potential.`
`TRANSMEM`	`205 225`	`21`	`Potential.`
`TRANSMEM`	`264 284`	`21`	`Potential.`
`TRANSMEM`	`298 318`	`21`	`Potential.`
`DOMAIN`	`130 331`	`202`	`TLC.`
`DNA_BIND`	`66 127`	`62`	`Homeobox.`
`COMPBIAS`	`346 355`	`10`	`Poly-Glu.`
`VARIANT`	`342 342`	`1`	`D -> G (in dbSNP:rs1023783 [NCBI]).`	`VAR_057276`
`VARIANT`	`370 370`	`1`	`G -> R (in dbSNP:rs2439928 [NCBI]).`	`VAR_019328`
`CONFLICT`	`144 144`		`Missing (in Ref. 1; AAH34500).`
`CONFLICT`	`316 316`		`L -> R (in Ref. 1; AAH28703).`

Sequence information

Length: 383 AA [This is the length of the unprocessed precursor]

Molecular weight: 46217 Da [This is the MW of the unprocessed precursor]

CRC64: 6711189C188C8569 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MFWTFKEWFW LERFWLPPTI KWSDLEDHDG LVFVKPSHLY VTIPYAFLLL IIRRVFEKFV 

        70         80         90        100        110        120 
ASPLAKSFGI KETVRKVTPN TVLENFFKHS TRQPLQTDIY GLAKKCNLTE RQVERWFRSR 

       130        140        150        160        170        180 
RNQERPSRLK KFQEACWRFA FYLMITVAGI AFLYDKPWLY DLWEVWNGYP KQPLLPSQYW 

       190        200        210        220        230        240 
YYILEMSFYW SLLFRLGFDV KRKDFLAHII HHLAAISLMS FSWCANYIRS GTLVMIVHDV 

       250        260        270        280        290        300 
ADIWLESAKM FSYAGWTQTC NTLFFIFSTI FFISRLIVFP FWILYCTLIL PMYHLEPFFS 

       310        320        330        340        350        360 
YIFLNLQLMI LQVLHLYWGY YILKMLNRCI FMKSIQDVRS DDEDYEEEEE EEEEEATKGK 

       370        380 
EMDCLKNGLG AERHLIPNGQ HGH

Q8IU89 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools