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UniProtKB/Swiss-Prot entry Q8G500

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_BIFLO
Primary accession number Q8G500
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 30)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: BL1218
From
Bifidobacterium longum [TaxID: 216816] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCC 2705;
DOI=10.1073/pnas.212527599; PubMed=12381787 [NCBI, ExPASy, EBI, Israel, Japan]
Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract.";
Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE014295; AAN25025.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_696389.1; -.
3D structure databases
HSSP P61495; 1IPD. [HSSP ENTRY / PDB]
ModBase Q8G500.
Enzyme and pathway databases
BioCyc BLON206672:BL1218-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01035; -; 1.
PBIL [Tree]
InterPro IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PROSITE PS00470; IDH_IMDH; FALSE_NEG.
BLOCKS Q8G500.
Genome annotation databases
GeneID 1022733; -.
GenomeReviews AE014295_GR; BL1218.
KEGG blo:BL1218; -.
Phylogenomic databases
HOGENOM Q8G500; -.
Genome annotation databases
CMR Q8G500; BL1218.
Other
ProtoNet Q8G500.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   343  343     3-isopropylmalate dehydrogenase. PRO_0000083794
NP_BIND   278   290  13     NAD (By similarity). 
METAL   218   218        Magnesium or manganese (By similarity). 
METAL   242   242        Magnesium or manganese (By similarity). 
METAL   246   246        Magnesium or manganese (By similarity). 
BINDING   94    94        Substrate (By similarity). 
BINDING   104   104        Substrate (By similarity). 
BINDING   128   128        Substrate (By similarity). 
BINDING   218   218        Substrate (By similarity). 
SITE   135   135  1     Important for catalysis (By similarity). 
SITE   185   185  1     Important for catalysis (By similarity). 
Sequence information
Length: 343 AA [This is the length of the unprocessed precursor] Molecular weight: 37246 Da [This is the MW of the unprocessed precursor] CRC64: 143417C91B926D30 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAKTYKIAVI PGDGIGKEVT PWAQKALEKA AEGVADFEYE NFDLGAERYL RDGAILPEDE 

        70         80         90        100        110        120 
EERIKANDAI LLGAVGDPRI KAGILERGLL LKLRFDLDQY VNLRPSKLYK GVTSPLANPG 

       130        140        150        160        170        180 
DIDFVVVREG TEGLYCGAGG AVRRNTPQEV ATEVSINTAY GVERVVRYAF KLAMKRKKHV 

       190        200        210        220        230        240 
TLVHKKNVLV NAGDMWQRIV DKVGEEYPEV THDYQHIDAA TIFLVSDPSR FDVILTDNLF 

       250        260        270        280        290        300 
GDILTDEAGS VVGGVGYSAS GCINASDEFP SMFEPIHGSA PDIAGQNKAN PTAAILSAAM 

       310        320        330        340 
LLEHLGFDDA AKKIHTAVEA DIEELGSTVR STDQVGKDIL ARM
Q8G500 in FASTA format

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