NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=DSM 44549 / YS-314 / AJ 12310 / JCM 11189 / NBRC 100395;
DOI=10.1101/gr.1285603; PubMed=12840036 [NCBI, ExPASy, EBI, Israel, Japan]
Nishio Y., Nakamura Y., Kawarabayasi Y., Usuda Y., Kimura E., Sugimoto S., Matsui K., Yamagishi A., Kikuchi H., Ikeo K., Gojobori T.;
"Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens.";
Genome Res. 13:1572-1579(2003).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000035; BAC17442.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_737242.1; -.

3D structure databases

ModBase

Q8FRX6.

Enzyme and pathway databases

BioCyc

CEFF196164:CE0632-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q8FRX6.

Genome annotation databases

1032751; -.

BA000035_GR; CE0632.

cef:CE0632; -.

fig|196164.1.peg.632; -.

Phylogenomic databases

HOGENOM

Q8FRX6; -.

Genome annotation databases

CMR

Q8FRX6; CE0632.

Other

ProtoNet

Q8FRX6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1073`	`1073`		`Error-prone DNA polymerase.`	`PRO_0000103377`

Sequence information

Length: 1073 AA [This is the length of the unprocessed precursor]

Molecular weight: 116229 Da [This is the MW of the unprocessed precursor]

CRC64: 827F8754ED71EE32 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVGMEWDTGA RGLTGRPLPW SMVEGILSGR EVGTPRPVLH EAEPECLSTP RPGPGSTEVP 

        70         80         90        100        110        120 
GERRGSRQGE RSGEIPFVEL HATSSYNFLA GASDPGEMVD RAHELGLSAL ALVDRDGLYG 

       130        140        150        160        170        180 
AVRFAEAAAE VGLATVFGAE LSLREGVLTV LCRGVEGYRR LSHLITGAAM SAGEKGSVDY 

       190        200        210        220        230        240 
PLLPQVAEQG AGHWVVLAGV EWQKKIDHLI ECFGRDNVVL EFPARMLPED TDHHDILRSI 

       250        260        270        280        290        300 
QTRTGLRGIL STMPTAATRD HVRLAGAKCA LALRANLAEA ESSLHPMGGT WLRSGGALAR 

       310        320        330        340        350        360 
AYPQCGDLLA TTVEIASGCA FTFDLVAPEL PRWDTPDGHT EMTWLTHLVE SRFDRRYRSR 

       370        380        390        400        410        420 
PAEVRERARA QIRHELGVIE QLGFPGYFLI VDDLVQFCHN ATILCQGRGS AANSAVCFVL 

       430        440        450        460        470        480 
GITNAEPITA GLLFERFLSR DRDGPPDIDI DIESGRREEV IQYVYTRYGR DNAAQVANVI 

       490        500        510        520        530        540 
TYRTKGALRD AARALGYPQG TVDAWSRGAS EPPADVVELA GQLKGQPRHL GIHSGGMVIC 

       550        560        570        580        590        600 
DRPIADVVPT EWARMEGRSV VQWDKDDCAA AGLVKFDLLG LGMLEALHHM MDLVAHHRGI 

       610        620        630        640        650        660 
TVNLWELDLA DAGVYDMLCR ADAVGVFQVE SRAQMSTLPR LKPRTFFDLV VEVALIRPGP 

       670        680        690        700        710        720 
IQGGSVHPYL RRRSGEEAVT YDHPVLEKSL GKTLGIPLFQ EQIMQIAVDA AGFTGGEADA 

       730        740        750        760        770        780 
LRRAMGSKRS PTRMAALRSR FYQGLADTHG IIGDTADKLW NKMVAFAAYG FPESHSQSFA 

       790        800        810        820        830        840 
TLVYFSAWFK HHYPAEFCAG LLRAQPMGFY SPQSLIADAR RHGVEILPIS INESGVQADA 

       850        860        870        880        890        900 
PDGHLRLGLD LVKGLGEEAA RRIAEHAPYT SIPDLSRRAD LGVAHIEALA RAGALDCLGV 

       910        920        930        940        950        960 
GRREALWQAG IAATERPGML PGISAIEAPA LPGMSAFELM ATSIAATGVT HDAQPMALLR 

       970        980        990       1000       1010       1020 
AHLDALGVVP ADRLLTDVAD GTRVRIAGVV THRQRPQTAS GVTFLGLEDE TGLMNVMVSP 

      1030       1040       1050       1060       1070 
GLWDRQRVLA RTAKTLIIRG IVQNATGAVN VVADKLEPLP VGEWLSRGSR DFR

Q8FRX6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools