[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=CMCP6; Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.; "Complete genome sequence of Vibrio vulnificus CMCP6."; Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Reduction of activated sulfate into sulfite.
CATALYTIC ACTIVITY: Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.
PATHWAY: Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the PAPS reductase family. CysH subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

AE016795; AAO09853.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_760326.1; -.

3D structure databases

HSSP

P17854; 1SUR. [HSSP ENTRY / PDB]

SMR

Q8CWK6; 7-235.

ModBase

Q8CWK6.

Enzyme and pathway databases

BioCyc

VVUL216895:VV1_1404-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004604;	Molecular function: phosphoadenylyl-sulfate reductase (thioredoxin) activity (inferred from electronic annotation from HAMAP).
GO:0016740;	Molecular function: transferase activity (inferred from electronic annotation from InterPro).
GO:0019344;	Biological process: cysteine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019379;	Biological process: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00063; -; 1.
PBIL [Tree]

InterPro

IPR004511; CysH.
IPR002500; PAPS_reduct.
IPR011800; PAPS_reductase.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.

Pfam

PF01507; PAPS_reduct; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00434; cysH; 1.
TIGR02057; PAPS_reductase; 1.

Genome annotation databases

GeneID

1178325; -.

GenomeReviews

AE016795_GR; VV1_1404.

KEGG

vvu:VV1_1404; -.

Phylogenomic databases

HOGENOM

Q8CWK6; -.

Genome annotation databases

CMR

Q8CWK6; VV1_1404.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 258`	`258`		`Phosphoadenosine phosphosulfate reductase.`	`PRO_0000100654`

Sequence information

Length: 258 AA [This is the length of the unprocessed precursor]

Molecular weight: 29448 Da [This is the MW of the unprocessed precursor]

CRC64: C5078F647D681687 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLDSVASTLQ LSELLSLTKA EQSIRLAEIN VELEMLSAQE RVAWALQNLE GAHAVSSSFG 

        70         80         90        100        110        120 
IQAAVMLHLV SKQQADIPVI LTDTGYLFPE TYQFIDELTK SLNLNLKVYR ANESANWQEA 

       130        140        150        160        170        180 
RYGKLWEQGI EGIEKYNKLN KVEPMRRALN ELNVKTWFSG LRREQSQSRA GLPILSIQNG 

       190        200        210        220        230        240 
VFKFLPVVDW SNKDVHYYLK EHGLSYHPLW EQGYLSVGDT HTTQKWEPGM SEEETRFFGL 

       250 
KRECGLHEED NEQDGSGI

Q8CWK6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools