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UniProtKB/Swiss-Prot entry Q8CQ91


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_STAES
Primary accession number Q8CQ91
Secondary accession numbers None
Integrated into Swiss-Prot on June 6, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Histidine biosynthesis bifunctional protein hisIE
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (PRA-CH)
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphatase
     (PRA-PH)
     (EC 3.6.1.31)
Gene name
Name: hisI
Synonyms: hisIE
OrderedLocusNames: SE_0277
From
Staphylococcus epidermidis (strain ATCC 12228) [TaxID: 176280] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1365-2958.2003.03671.x; PubMed=12950922 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228).";
Mol. Microbiol. 49:1577-1593(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015929; AAO03874.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_763832.1; -.
3D structure databases
ModBase Q8CQ91.
Enzyme and pathway databases
BioCyc SEPI176280:SE_0277-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01019; -; 1.
PBIL [Tree]
InterPro IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
Pfam PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
ProDom PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03188; histidine_hisI; 1.
BLOCKS Q8CQ91.
ProtoNet Q8CQ91.
Genome annotation databases
GeneID 1058076; -.
GenomeReviews AE015929_GR; SE_0277.
KEGG sep:SE0277; -.
Phylogenomic databases
HOGENOM Q8CQ91; -.
Genome annotation databases
CMR Q8CQ91; SE_0277.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   211  211     Histidine biosynthesis bifunctional protein hisIE. PRO_0000136436
REGION   1   107  107     Phosphoribosyl-AMP cyclohydrolase. 
REGION   108   211  104     Phosphoribosyl-ATP pyrophosphohydrolase. 
Sequence information
Length: 211 AA [This is the length of the unprocessed precursor] Molecular weight: 24334 Da [This is the MW of the unprocessed precursor] CRC64: 444A8063ABF82AF6 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNKLIDFSKG LVPVILQHAQ TDSVLMLGYM NEEAYQKTLK EKKVTFFSRS KQRLWTKGET 

        70         80         90        100        110        120 
SGHFQHVESI HLDCDQDAIL IKVMPQGPTC HTGSLSCFNS EIESRFKIQA LAQTIHQSAK 

       130        140        150        160        170        180 
SNQSNSYTQY LLKEGIEKIS KKFGEEAFEV VIGAIKHNRE EVINETADVM YHLFVLLHSL 

       190        200        210 
DIPFSEVEQV LAHRHQKRNN FKGERKKVQE W 

Q8CQ91 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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