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UniProtKB/Swiss-Prot entry Q8CNZ0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HEM2_STAES
Primary accession number Q8CNZ0
Secondary accession numbers None
Integrated into Swiss-Prot on November 28, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 38)
Name and origin of the protein
Protein name Delta-aminolevulinic acid dehydratase
Synonyms ALADH
ALAD
EC 4.2.1.24
Porphobilinogen synthase
Gene name
Name: hemB
OrderedLocusNames: SE_1343
From
Staphylococcus epidermidis (strain ATCC 12228) [TaxID: 176280] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1365-2958.2003.03671.x; PubMed=12950922 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228).";
Mol. Microbiol. 49:1577-1593(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015929; AAO04942.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_764898.1; -.
3D structure databases
HSSP Q59643; 1B4K. [HSSP ENTRY / PDB]
ModBase Q8CNZ0.
Enzyme and pathway databases
BioCyc SEPI176280:SE_1343-MON; -.
Ontologies
GO
GO:0004655; Molecular function: porphobilinogen synthase activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006779; Biological process: porphyrin biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001731; 4pyrrol_synth_porphobiln_synth.
IPR013785; Aldolase_TIM.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
PANTHER PTHR11458; AlaD_dehydratase; 1.
Pfam PF00490; ALAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001415; Porphbilin_synth; 1.
PRINTS PR00144; DALDHYDRTASE.
ProDom PD002304; AlaD_dehydratase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00169; D_ALA_DEHYDRATASE; 1.
BLOCKS Q8CNZ0.
ProtoNet Q8CNZ0.
Genome annotation databases
GeneID 1056288; -.
GenomeReviews AE015929_GR; SE_1343.
KEGG sep:SE1343; -.
Phylogenomic databases
HOGENOM Q8CNZ0; -.
Genome annotation databases
CMR Q8CNZ0; SE_1343.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Lyase; Porphyrin biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   324  324     Delta-aminolevulinic acid dehydratase. PRO_0000140517
REGION   115   133  19     Zinc-binding (By similarity). 
ACT_SITE   248   248        By similarity. 
Sequence information
Length: 324 AA [This is the length of the unprocessed precursor] Molecular weight: 36570 Da [This is the MW of the unprocessed precursor] CRC64: 31685329B5943A51 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKFDRHRRLR SSKTMRDLVR ETHVRKEDLI YPIFVVEQDD IKSEIKSLPG IYQISLNLLH 

        70         80         90        100        110        120 
EEIKEAYDLG IRAIMFFGVP NDKDDIGSGA YDHNGVVQEA TRISKNLYKD LLIVADTCLC 

       130        140        150        160        170        180 
EYTDHGHCGV IDDHTHDVDN DKSLPLLVKT AISQVEAGAD IIAPSNMMDG FVAEIREGLD 

       190        200        210        220        230        240 
QAGYQNIPIM SYGIKYASSF FGPFRDAADS APSFGDRKTY QMDPANRLEA LRELESDLKE 

       250        260        270        280        290        300 
GCDMMIVKPS LSYLDIIRDV KNNTNVPVVA YNVSGEYSMT KAAALNGWID EEKIVMEQMI 

       310        320 
SMKRAGADLI ITYFAKDICR YLDK
Q8CNZ0 in FASTA format

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