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UniProtKB/Swiss-Prot entry Q8CNX4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDH_STAES
Primary accession number Q8CNX4
Secondary accession numbers None
Integrated into Swiss-Prot on November 28, 2003
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: icd
Synonyms: citC
OrderedLocusNames: SE_1370
From
Staphylococcus epidermidis (strain ATCC 12228) [TaxID: 176280] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Staphylococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1365-2958.2003.03671.x; PubMed=12950922 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q., Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H., Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
"Genome-based analysis of virulence genes in a non-biofilm-forming Staphylococcus epidermidis strain (ATCC 12228).";
Mol. Microbiol. 49:1577-1593(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015929; AAO04969.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_764925.1; -.
3D structure databases
HSSP P39126; 1HQS. [HSSP ENTRY / PDB]
SMR Q8CNX4; 3-421.
ModBase Q8CNX4.
Enzyme and pathway databases
BioCyc SEPI176280:SE_1370-MON; -.
Family and domain databases
InterPro IPR004439; IsoCit_DHase_NADP_prok.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
PTHR11835:SF1; NADP_IDH_prok; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00183; prok_nadp_idh; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q8CNX4.
Genome annotation databases
GeneID 1058012; -.
GenomeReviews AE015929_GR; SE_1370.
KEGG sep:SE1370; -.
Phylogenomic databases
HOGENOM Q8CNX4; -.
Genome annotation databases
CMR Q8CNX4; SE_1370.
Other
ProtoNet Q8CNX4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   422  422     Isocitrate dehydrogenase [NADP]. PRO_0000083565
NP_BIND   344   350  7     NADP (By similarity). 
METAL   310   310        Magnesium or manganese (By similarity). 
BINDING   94    94        NADP (By similarity). 
BINDING   103   103        Substrate (By similarity). 
BINDING   105   105        Substrate (By similarity). 
BINDING   109   109        Substrate (By similarity). 
BINDING   119   119        Substrate (By similarity). 
BINDING   143   143        Substrate (By similarity). 
BINDING   357   357        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
BINDING   396   396        NADP (By similarity). 
BINDING   400   400        NADP (By similarity). 
SITE   150   150  1     Critical for catalysis (By similarity). 
SITE   220   220  1     Critical for catalysis (By similarity). 
Sequence information
Length: 422 AA [This is the length of the unprocessed precursor] Molecular weight: 46619 Da [This is the MW of the unprocessed precursor] CRC64: 31EA599CF275A83C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSAEKITQSK DGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN GEKRIEWKEV 

        70         80         90        100        110        120 
LAGQKAYDET GEWLPQETLE TIKEYLIAVK GPLTTPIGGG IRSLNVALRQ ELDLFTCLRP 

       130        140        150        160        170        180 
VRWFKGVPSP VKRPEDVDMV IFRENTEDIY AGIEFKQGTS EVKKVIDFLQ NEMGATNIRF 

       190        200        210        220        230        240 
PETSGIGIKP VSKEGTERLV RAAIQYALDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAH 

       250        260        270        280        290        300 
NEFGDKVFTW QQYDEIVEQK GKDAANEAQS KAEQEGKIII KDSIADIFLQ QILTRPAEHD 

       310        320        330        340        350        360 
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY AGLNKVNPSS 

       370        380        390        400        410        420 
EILSSVLMLE HLGWQEAADK ITDSIEATIA SKIVTYDFAR LMDGAKEVST SDFADELIKN 


IR
Q8CNX4 in FASTA format

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