ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8CFG8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name CS1B_MOUSE
Primary accession number Q8CFG8
Secondary accession numbers None
Integrated into Swiss-Prot on September 27, 2005
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name Complement C1s-B subcomponent [Precursor]
Synonyms EC 3.4.21.42
C1 esterase
Contains Complement C1s-B subcomponent heavy chain
Complement C1s-B subcomponent light chain
Gene name
Name: C1sb
Synonyms: C1s
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6;
DOI=10.1042/BJ20021555; PubMed=12513694 [NCBI, ExPASy, EBI, Israel, Japan]
Garnier G., Circolo A., Xu Y., Volanakis J.E.;
"Complement C1r and C1s genes are duplicated in the mouse: differential expression generates alternative isomorphs in the liver and in the male reproductive system.";
Biochem. J. 371:631-640(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF459020; AAO15559.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_776289.1; -.
UniGene Mm.219527
3D structure databases
HSSP Q9UCV4; 1NZI. [HSSP ENTRY / PDB]
SMR Q8CFG8; 18-174, 359-683.
ModBase Q8CFG8.
Protein family/group databases
MEROPS S01.210; -.
PTM databases
PhosphoSite Q8CFG8; -.
Organism-specific databases
MGI MGI:3644269; EG317677.
Gene expression databases
ArrayExpress Q8CFG8; -.
CleanEx MM_C1S; -.
GermOnline ENSMUSG00000038521; Mus musculus.
Ontologies
GO
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from InterPro).
GO:0004252; Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0006958; Biological process: complement activation, classical pathway (inferred from electronic annotation from UniProtKB-KW).
GO:0045087; Biological process: innate immune response (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016060; Complement_control_module.
IPR000859; CUB.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR006209; EGF_like.
IPR013032; EGF_like_reg_CS.
IPR001254; Peptidase_S1_S6.
IPR001314; Peptidase_S1A.
IPR000436; Sushi_SCR_CCP.
Graphical view of domain structure.
Gene3D G3DSA:2.10.70.10; Complement_control_module; 1.
G3DSA:2.60.120.290; CUB; 2.
Pfam PF00431; CUB; 2.
PF00008; EGF; 1.
PF00084; Sushi; 2.
PF00089; Trypsin; 1.
Pfam graphical view of domain structure.
PRINTS PR00722; CHYMOTRYPSIN.
SMART SM00032; CCP; 2.
SM00042; CUB; 2.
SM00179; EGF_CA; 1.
SM00020; Tryp_SPc; 1.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 1.
PS01180; CUB; 2.
PS00022; EGF_1; FALSE_NEG.
PS01186; EGF_2; FALSE_NEG.
PS50026; EGF_3; FALSE_NEG.
PS01187; EGF_CA; 1.
PS50923; SUSHI; 2.
PS50240; TRYPSIN_DOM; 1.
PS00134; TRYPSIN_HIS; FALSE_NEG.
PS00135; TRYPSIN_SER; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8CFG8.
ProtoNet Q8CFG8.
Genome annotation databases
Ensembl ENSMUSG00000079343; Mus musculus. [Contig view]
GeneID 317677; -.
KEGG mmu:317677; -.
Phylogenomic databases
HOVERGEN Q8CFG8; -.
Other
NextBio 394148; -.
SOURCE C1sb; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Complement pathway; EGF-like domain; Glycoprotein; Hydrolase; Hydroxylation; Immune response; Innate immunity; Metal-binding; Protease; Repeat; Serine protease; Signal; Sushi.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    15  15     By similarity. 
CHAIN   16   688  673     Complement C1s-B subcomponent. PRO_0000042196
CHAIN   16   437  422     Complement C1s-B subcomponent heavy chain (By similarity). PRO_0000042197
CHAIN   438   688  251     Complement C1s-B subcomponent light chain (By similarity). PRO_0000042198
DOMAIN   16   130  115     CUB 1. 
DOMAIN   131   172  42     EGF-like; calcium-binding (Potential). 
DOMAIN   175   290  116     CUB 2. 
DOMAIN   292   356  65     Sushi 1. 
DOMAIN   357   423  67     Sushi 2. 
DOMAIN   438   680  243     Peptidase S1. 
ACT_SITE   475   475        Charge relay system (By similarity). 
ACT_SITE   529   529        Charge relay system (By similarity). 
ACT_SITE   631   631        Charge relay system (By similarity). 
METAL   60    60        Calcium (By similarity). 
METAL   68    68        Calcium (By similarity). 
METAL   113   113        Calcium (By similarity). 
METAL   131   131        Calcium (By similarity). 
METAL   132   132        Calcium; via carbonyl oxygen (By similarity). 
METAL   134   134        Calcium (By similarity). 
METAL   149   149        Calcium (By similarity). 
METAL   150   150        Calcium; via carbonyl oxygen (By similarity). 
METAL   153   153        Calcium; via carbonyl oxygen (By similarity). 
MOD_RES   149   149        3-hydroxyasparagine (By similarity). 
CARBOHYD   174   174        N-linked (GlcNAc...) (Potential). 
DISULFID   65    83        By similarity. 
DISULFID   135   147        By similarity. 
DISULFID   143   156        By similarity. 
DISULFID   158   171        By similarity. 
DISULFID   175   202        By similarity. 
DISULFID   234   251        By similarity. 
DISULFID   294   341        By similarity. 
DISULFID   321   354        By similarity. 
DISULFID   359   403        By similarity. 
DISULFID   386   421        By similarity. 
DISULFID   425   549        Interchain (between heavy and light chains) (By similarity). 
DISULFID   595   618        By similarity. 
DISULFID   627   659        By similarity. 
Sequence information
Length: 688 AA [This is the length of the unprocessed precursor] Molecular weight: 76700 Da [This is the MW of the unprocessed precursor] CRC64: F10A1DC565875A73 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MWYLVLFSLL ASFSAEPTMH GEILSPNYPQ AYPNDVVKSW DIEVPEGFGI HLYFTHVDIE 

        70         80         90        100        110        120 
PSESCAYDSV QIISGGIEEG RLCGQRTSKS PNSPIIEEFQ FPYNKLQVVF TSDFSIEEQF 

       130        140        150        160        170        180 
TGFAAYYTAI DVNECTDFTD VPCSHFCNNF IGGYFCSCPP EYFLHDDMRN CGVNCSGDVF 

       190        200        210        220        230        240 
TALIGEISSP NYPNPYPENS RCEYQIQLQE GFQVVVTMQR EDFDVEPADS EGNCPDSLTF 

       250        260        270        280        290        300 
AAKNQQFGPY CGDGFPGPLT IRTQSNTLGI VFQTDLMGQK KGWKLRYHGD PISCPKESTA 

       310        320        330        340        350        360 
NSNWEPDKAK YVFKDVVKIT CVDGFEVVEG HVSSTSYYST CQSDGQWSNS GLKCQPVYCG 

       370        380        390        400        410        420 
IPDPIANGKV EEPENSVFGT VIHYTCEEPY YYMEHEEGGE YRCAANGRWV NDQLGIELPR 

       430        440        450        460        470        480 
CIPVCGVPTE PFQVQQKIFG GQPAKIENFP WQVFFNHPTA GGALINEYWV LTAAHVVEKN 

       490        500        510        520        530        540 
SDPSMYAGIT ALRLADLENA QRLYTKRVII HPGWKEDDDL NPRTNFDNDI ALVQLKDPVK 

       550        560        570        580        590        600 
MGPKFSPICL PGTSSEYNLS PGDMGLISGW GRTEKRLHVI NLRGAKVPVT SLETCKQVKE 

       610        620        630        640        650        660 
ENPTARPEDY VITDNMICAG EKGVDSCKGD SGGAFAFQVP NVKAPKFYVA GLVSWGKKCG 

       670        680 
AYGVYTKVKN YVDWILKTMQ ENSGPRKD
Q8CFG8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by au flag APAF Australia Mirror sites: Brazil Canada China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!