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UniProtKB/Swiss-Prot entry Q8BRH4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MLL3_MOUSE
Primary accession number Q8BRH4
Secondary accession numbers Q5YLV9 Q8BK12 Q8C6M3 Q923H5 Q923H6
Integrated into Swiss-Prot on October 10, 2003
Sequence was last modified on October 10, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 60)
Name and origin of the protein
Protein name Histone-lysine N-methyltransferase MLL3
Synonyms EC 2.1.1.43
Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
Gene name
Name: Mll3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
STRAIN=BALB/c;
TISSUE=Testis;
DOI=10.1016/j.gene.2005.11.013; PubMed=16459028 [NCBI, ExPASy, EBI, Israel, Japan]
Brun M.-E., Gasca S., Girard C., Bouton K., De Massy B., De Sario A.;
"Characterization and expression analysis during embryo development of the mouse ortholog of MLL3.";
Gene 371:25-33(2006).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
The mouse genome sequencing consortium;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-814 AND 4803-4903.
STRAIN=C57BL/6J;
TISSUE=Embryo;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
 NUCLEOTIDE SEQUENCE [MRNA] OF 957-1376 AND 4214-4894.
TISSUE=Myeloma;
PubMed=11718452 [NCBI, ExPASy, EBI, Israel, Japan]
Tan Y.C., Chow V.T.;
"Novel human HALR (MLL3) gene encodes a protein homologous to ALR and to ALL-1 involved in leukemia, and maps to chromosome 7q36 associated with leukemia and developmental defects.";
Cancer Detect. Prev. 25:454-469(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY138582; AAN11291.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC116469; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC127319; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AC134910; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AK044828; BAC32109.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK054270; BAC35712.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK077567; BAC36867.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY036886; AAK70213.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY036887; AAK70214.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.332268
3D structure databases
HSSP Q9UIG0; 1F62. [HSSP ENTRY / PDB]
ModBase Q8BRH4.
PTM databases
PhosphoSite Q8BRH4; -.
Organism-specific databases
MGI MGI:2444959; Mll3.
Gene expression databases
ArrayExpress Q8BRH4; -.
CleanEx MM_MLL3; -.
GermOnline ENSMUSG00000038056; Mus musculus.
Ontologies
GO
GO:0005634; Cellular component: nucleus (inferred from electronic annotation from InterPro).
GO:0018024; Molecular function: histone-lysine N-methyltransferase activity (inferred from electronic annotation from EC).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0003700; Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0016568; Biological process: chromatin modification (inferred from electronic annotation from UniProtKB-KW).
GO:0007242; Biological process: intracellular signaling cascade (inferred from electronic annotation from InterPro).
GO:0006355; Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000637; AT_hook_DNA_bd.
IPR002219; DAG_PE_bd.
IPR003889; FYrich_C.
IPR003888; FYrich_N.
IPR000910; HMG_1/2_box.
IPR003616; Post-SET_Zn_bd.
IPR001214; SET.
IPR001594; Znf_DHHC.
IPR001965; Znf_PHD.
IPR001841; Znf_RING.
IPR013083; Znf_RING/FYVE/PHD.
Graphical view of domain structure.
Gene3D G3DSA:3.30.40.10; Znf_RING/FYVE/PHD; 3.
Pfam PF02178; AT_hook; 1.
PF05965; FYRC; 1.
PF05964; FYRN; 1.
PF00505; HMG_box; 1.
PF00628; PHD; 6.
PF00856; SET; 1.
Pfam graphical view of domain structure.
SMART SM00384; AT_hook; 2.
SM00109; C1; 2.
SM00542; FYRC; 1.
SM00541; FYRN; 1.
SM00398; HMG; 1.
SM00249; PHD; 8.
SM00508; PostSET; 1.
SM00184; RING; 4.
SM00317; SET; 1.
SMART graphical view of domain structure.
PROSITE PS00354; HMGI_Y; 1.
PS50868; POST_SET; 1.
PS50280; SET; 1.
PS50216; ZF_DHHC; 1.
PS01359; ZF_PHD_1; 5.
PS50016; ZF_PHD_2; 6.
PS50089; ZF_RING_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8BRH4.
ProtoNet Q8BRH4.
Genome annotation databases
Ensembl ENSMUSG00000038056; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q8BRH4; -.
HOVERGEN Q8BRH4; -.
Other
SOURCE Mll3; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Activator; Alternative splicing; Chromatin regulator; Coiled coil; DNA-binding; Metal-binding; Methyltransferase; Nucleus; Phosphoprotein; Repeat; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase; Zinc; Zinc-finger.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   4903  4903     Histone-lysine N-methyltransferase MLL3. PRO_0000124880
DOMAIN   4762   4883  122     SET. 
DOMAIN   4887   4903  17     Post-SET. 
DNA_BIND   34     46  13     A.T hook. 
ZN_FING   340    390  51     PHD-type 1. 
ZN_FING   343    388  46     RING-type. 
ZN_FING   387    437  51     PHD-type 2. 
ZN_FING   435    488  54     DHHC-type. 
ZN_FING   463    519  57     PHD-type 3. 
ZN_FING   950   1003  54     PHD-type 4. 
ZN_FING   1000   1050  51     PHD-type 5. 
ZN_FING   1077   1132  56     PHD-type 6. 
COILED   1330   1352  23     Potential. 
COILED   1743   1790  48     Potential. 
COILED   3047   3074  28     Potential. 
COILED   3166   3193  28     Potential. 
COILED   3224   3270  47     Potential. 
COILED   3387   3432  46     Potential. 
COMPBIAS   384    487  104     Cys-rich. 
COMPBIAS   970   1099  130     Cys-rich. 
COMPBIAS   1519   1568  50     Pro-rich. 
COMPBIAS   1708   1787  80     Gln-rich. 
COMPBIAS   1831   2622  792     Pro-rich. 
COMPBIAS   2682   2780  99     Asp-rich. 
COMPBIAS   3022   3504  483     Gln-rich. 
MOD_RES   2803   2803        N6-acetyllysine (By similarity). 
MOD_RES   4011   4011        Phosphotyrosine (By similarity). 
MOD_RES   4015   4015        Phosphoserine (By similarity). 
MOD_RES   4027   4027        Phosphoserine (By similarity). 
MOD_RES   4043   4043        Phosphoserine (By similarity). 
VAR_SEQ   839    878        Missing (in isoform 2). VSP_020568
VAR_SEQ   1414   1448        Missing (in isoform 2). VSP_020569
VAR_SEQ   1791   3080        Missing (in isoform 2). VSP_020570
VAR_SEQ   3814   3884        Missing (in isoform 2). VSP_020571
VAR_SEQ   4714   4717        Missing (in isoform 2). VSP_020572
CONFLICT   28     36        SPAAADKRP -> RSFVCGCGA (in Ref. 1). 
CONFLICT   276    276        V -> A (in Ref. 1). 
CONFLICT   433    440        NCRICIEC -> VSDFLICF (in Ref. 3; BAC32109). 
CONFLICT   533    533        E -> G (in Ref. 1). 
CONFLICT   577    577        D -> DA (in Ref. 1). 
CONFLICT   675    675        S -> C (in Ref. 3; BAC35712). 
CONFLICT   720    720        K -> E (in Ref. 1). 
CONFLICT   763    763        F -> L (in Ref. 1). 
CONFLICT   791    791        H -> Y (in Ref. 1). 
CONFLICT   1324   1325        VD -> LH (in Ref. 1). 
CONFLICT   1737   1737        E -> V (in Ref. 1). 
CONFLICT   1776   1776        Q -> R (in Ref. 1). 
CONFLICT   3236   3236        M -> MM (in Ref. 1). 
CONFLICT   3423   3424        QR -> P (in Ref. 1). 
CONFLICT   3657   3657        E -> G (in Ref. 1). 
CONFLICT   3668   3668        A -> V (in Ref. 1). 
CONFLICT   4283   4283        C -> Y (in Ref. 1). 
CONFLICT   4306   4306        E -> D (in Ref. 1). 
CONFLICT   4520   4520        Q -> R (in Ref. 1). 
CONFLICT   4531   4531        V -> G (in Ref. 1). 
CONFLICT   4649   4649        Y -> H (in Ref. 1). 
Sequence information
Length: 4903 AA [This is the length of the unprocessed precursor] Molecular weight: 540187 Da [This is the MW of the unprocessed precursor] CRC64: 0B896490B081BA6C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK 

        70         80         90        100        110        120 
STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS SKQPVSALQR SVSEESANSL 

       130        140        150        160        170        180 
VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC 

       190        200        210        220        230        240 
EKIQNYAPRK QRGQRKERPP QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA 

       250        260        270        280        290        300 
LFDSTGTCWA HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 

       310        320        330        340        350        360 
CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG DLLDQFFCTT 

       370        380        390        400        410        420 
CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS KMLVCDTCDK GYHTFCLQPV 

       430        440        450        460        470        480 
MKSVPTNGWK CKNCRICIEC GTRSSTQWHH NCLICDTCYQ QQDNLCPFCG KCYHPELQKD 

       490        500        510        520        530        540 
MLHCNMCKRW VHLECDKPTD QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD 

       550        560        570        580        590        600 
YASGMEIEGT EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 

       610        620        630        640        650        660 
TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN IEVLPHQTIV 

       670        680        690        700        710        720 
PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER SLSCKEPLLT ERVQEEMEQK 

       730        740        750        760        770        780 
ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD KYVELPAEEE STFSSATDLN KADVSSSSTL 

       790        800        810        820        830        840 
CSDLPSCDML HGYPPAFNSA AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW 

       850        860        870        880        890        900 
SNHNTVSPPS WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR 

       910        920        930        940        950        960 
GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ DMCVVCGSFG 

       970        980        990       1000       1010       1020 
QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC TVCEACGKAT DPGRLLLCDD 

      1030       1040       1050       1060       1070       1080 
CDISYHTYCL DPPLQTVPKG GWKCKWCVWC RHCGATSAGL RCEWQNNYTQ CAPCASLSSC 

      1090       1100       1110       1120       1130       1140 
PVCCRNYREE DLILQCRQCD RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS 

      1150       1160       1170       1180       1190       1200 
SDCCDSSLVA QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK 

      1210       1220       1230       1240       1250       1260 
IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG DDETKGIEGT 

      1270       1280       1290       1300       1310       1320 
DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS SGSISEQLPS RDDGWREQLP 

      1330       1340       1350       1360       1370       1380 
DTLVDEPVSV AENTDKIKKR YRKRKNKLEE TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS 

      1390       1400       1410       1420       1430       1440 
EDAAQLSFKT GFLDPSSDPL LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD 

      1450       1460       1470       1480       1490       1500 
LAKSVDHSDI GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK 

      1510       1520       1530       1540       1550       1560 
IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL MNGLIGPSPH 

      1570       1580       1590       1600       1610       1620 
LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP NSSWAPTTPS MEGENDTLSN 

      1630       1640       1650       1660       1670       1680 
AQRSTLKWEK EEALGEMATV APVLYTNINF PNLKEEFPDW TTRVKQIAKL WRKASSQERA 

      1690       1700       1710       1720       1730       1740 
PYVQKARDNR AALRINKVQM SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW 

      1750       1760       1770       1780       1790       1800 
KFRQQMRQKS KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS 

      1810       1820       1830       1840       1850       1860 
GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP PPSTPSRIPV 

      1870       1880       1890       1900       1910       1920 
QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT PRPPPGGHSF PRRNSVTPVE 

      1930       1940       1950       1960       1970       1980 
NCVPLSSVPR PIHMNETSAT RPSPARDLCA SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL 

      1990       2000       2010       2020       2030       2040 
PRSPVISEQS TKGPLTTGTS DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP 

      2050       2060       2070       2080       2090       2100 
LHPPPSQDPY GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE 

      2110       2120       2130       2140       2150       2160 
SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD PYSQPPGTPR 

      2170       2180       2190       2200       2210       2220 
PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL GPPRPGISVP YSQPPAVPRP 

      2230       2240       2250       2260       2270       2280 
RTSEGFTRPS SARPALMPNQ DPFLQAAQNR VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF 

      2290       2300       2310       2320       2330       2340 
THASSSAVRD PYDQPPVTPR PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ 

      2350       2360       2370       2380       2390       2400 
QFSSVSQLPG PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG 

      2410       2420       2430       2440       2450       2460 
PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV FPKDQRGPYP 

      2470       2480       2490       2500       2510       2520 
PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS GIPPHIRRPM SMEMPRPSNN 

      2530       2540       2550       2560       2570       2580 
PPLNNPVGLP QHFPPQGLPV QQHNILGQAF IELRHRAPDG RSRLPFAASP SSVIESPSHP 

      2590       2600       2610       2620       2630       2640 
RHGNFLPRPD FPGPRHTDPI RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP 

      2650       2660       2670       2680       2690       2700 
LNHPLSGEFS EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE 

      2710       2720       2730       2740       2750       2760 
VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA YTDPELDLGD 

      2770       2780       2790       2800       2810       2820 
KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL EDKDLPQRKS SVSSEIKTEA 

      2830       2840       2850       2860       2870       2880 
LSPYSKEEIQ SEIKNHDDSR GDADTACSQA ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE 

      2890       2900       2910       2920       2930       2940 
NAGPVVSAIQ GSTPLPARDV MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS 

      2950       2960       2970       2980       2990       3000 
PSTHGSSLPP TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG 

      3010       3020       3030       3040       3050       3060 
TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD LLDQERQEQQ 

      3070       3080       3090       3100       3110       3120 
QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI NKVMAQNSLG MPPMVMSRFP 

      3130       3140       3150       3160       3170       3180 
FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH QISRPNPPNF GPGFVNDSQR KQYEEWLQET 

      3190       3200       3210       3220       3230       3240 
QQLLQMQQKY LEEQIGAHRK SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ 

      3250       3260       3270       3280       3290       3300 
LEQIRKQQKE HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF 

      3310       3320       3330       3340       3350       3360 
PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP IAQLSLKTCT 

      3370       3380       3390       3400       3410       3420 
PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL REQQERQRVQ LMQEVDRQRA 

      3430       3440       3450       3460       3470       3480 
LQQRMEMEQH CLMGAELANR TPVSQMPFYG SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ 

      3490       3500       3510       3520       3530       3540 
QNVQQGSVNS PPNQTFMQTN EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ 

      3550       3560       3570       3580       3590       3600 
QSPLRPPFTP ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK 

      3610       3620       3630       3640       3650       3660 
RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ RQQEPVEPVP 

      3670       3680       3690       3700       3710       3720 
VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD KPSVETPNKT EEIKLEKAET 

      3730       3740       3750       3760       3770       3780 
QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC PSHPVGTPTT KGDTGNELLK HLLKNKKASS 

      3790       3800       3810       3820       3830       3840 
LLTQKPEGTL SSDESSTKDG KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK 

      3850       3860       3870       3880       3890       3900 
KQRSKRTQRT GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT 

      3910       3920       3930       3940       3950       3960 
PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL LARAIAQGPK 

      3970       3980       3990       4000       4010       4020 
TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP ESVVGVEVNK YPDLSLVKEE 

      4030       4040       4050       4060       4070       4080 
PPEPVPSPII PILPSISGKN SESRRNDIKT EPGTLFFTSP FGSSPNGPRS GLISVAITLH 

      4090       4100       4110       4120       4130       4140 
PTAAENISSV VAAFSDLLHV RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP 

      4150       4160       4170       4180       4190       4200 
PPGSANPPRL ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG 

      4210       4220       4230       4240       4250       4260 
SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN KESLPSLPQS 

      4270       4280       4290       4300       4310       4320 
PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS FPPAFEAAKV ESKPDELKVT 

      4330       4340       4350       4360       4370       4380 
VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT 

      4390       4400       4410       4420       4430       4440 
CLKPDPVPKD CRKCCFCHEE GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI 

      4450       4460       4470       4480       4490       4500 
NVELALRRGL QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP 

      4510       4520       4530       4540       4550       4560 
KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI GQLLPQQMQA 

      4570       4580       4590       4600       4610       4620 
FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR PVFVIRIVEQ GHEDLVLSDS 

      4630       4640       4650       4660       4670       4680 
SPKDVWDKIL EPVACVRKKS EMLQLFPAYL KGEDLFGLTV SAVARIAESL PGVEACENYT 

      4690       4700       4710       4720       4730       4740 
FRYGRNPLME LPLAVNPTGC ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA 

      4750       4760       4770       4780       4790       4800 
PYSKQFVHSK SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE 

      4810       4820       4830       4840       4850       4860 
VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE VVTFERGHKI 

      4870       4880       4890       4900 
IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK WMN
Q8BRH4 in FASTA format

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