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UniProtKB/Swiss-Prot entry Q8BNJ2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATS4_MOUSE
Primary accession number Q8BNJ2
Secondary accession number Q8K384
Integrated into Swiss-Prot on May 10, 2005
Sequence was last modified on May 10, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name A disintegrin and metalloproteinase with thrombospondin motifs 4 [Precursor]
Synonyms ADAMTS-4
ADAM-TS 4
ADAM-TS4
EC 3.4.24.82
Aggrecanase-1
Gene name
Name: Adamts4
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK083534; BAC38944.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC027773; AAH27773.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.23156
3D structure databases
HSSP P07996; 1LSL. [HSSP ENTRY / PDB]
ModBase Q8BNJ2.
Protein family/group databases
MEROPS M12.221; -.
PTM databases
PhosphoSite Q8BNJ2; -.
Organism-specific databases
MGI MGI:1339949; Adamts4.
Gene expression databases
ArrayExpress Q8BNJ2; -.
GermOnline ENSMUSG00000006403; Mus musculus.
Ontologies
GO
GO:0005578; Cellular component: proteinaceous extracellular matrix (inferred from electronic annotation from InterPro).
GO:0004222; Molecular function: metalloendopeptidase activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR010294; ADAM_spacer1.
IPR001762; Blood-coag_inhib_Disintegrin.
IPR006025; Pept_M_Zn_BS.
IPR001590; Peptidase_M12B.
IPR013273; Peptidase_M12B_ADAM-TS.
IPR002870; Peptidase_M12B_N.
IPR000884; TSP1.
IPR008085; TSP_1.
Graphical view of domain structure.
Pfam PF05986; ADAM_spacer1; 1.
PF01562; Pep_M12B_propep; 1.
PF01421; Reprolysin; 1.
PF00090; TSP_1; 1.
Pfam graphical view of domain structure.
PRINTS PR01857; ADAMTSFAMILY.
PR01705; TSP1REPEAT.
SMART SM00209; TSP1; 1.
SMART graphical view of domain structure.
PROSITE PS50215; ADAM_MEPRO; 1.
PS00427; DISINTEGRIN_1; FALSE_NEG.
PS50214; DISINTEGRIN_2; FALSE_NEG.
PS50092; TSP1; 1.
PS00142; ZINC_PROTEASE; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8BNJ2.
ProtoNet Q8BNJ2.
Genome annotation databases
Ensembl ENSMUSG00000006403; Mus musculus. [Contig view]
Phylogenomic databases
HOVERGEN Q8BNJ2; -.
Other
SOURCE Adamts4; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cleavage on pair of basic residues; Extracellular matrix; Glycoprotein; Hydrolase; Metal-binding; Metalloprotease; Protease; Secreted; Signal; Zinc; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    49  49     Potential. 
PROPEP   50   208  159     By similarity. PRO_0000029166
CHAIN   209   833  625     A disintegrin and metalloproteinase with thrombospondin motifs 4. PRO_0000029167
DOMAIN   214   424  211     Peptidase M12B. 
DOMAIN   433   515  83     Disintegrin. 
DOMAIN   516   571  56     TSP type-1. 
REGION   682   833  152     Spacer. 
MOTIF   188   195  8     Cysteine switch (By similarity). 
ACT_SITE   358   358        By similarity. 
METAL   190   190        Zinc; in inhibited form (By similarity). 
METAL   357   357        Zinc; catalytic (By similarity). 
METAL   361   361        Zinc; catalytic (By similarity). 
METAL   367   367        Zinc; catalytic (By similarity). 
CARBOHYD   63    63        N-linked (GlcNAc...) (Potential). 
CARBOHYD   299   299        N-linked (GlcNAc...) (Potential). 
DISULFID   335   419        By similarity. 
DISULFID   373   403        By similarity. 
DISULFID   528   565        By similarity. 
DISULFID   532   570        By similarity. 
DISULFID   543   555        By similarity. 
CONFLICT   18    18        Q -> R (in Ref. 2; AAH27773). 
Sequence information
Length: 833 AA [This is the length of the unprocessed precursor] Molecular weight: 90070 Da [This is the MW of the unprocessed precursor] CRC64: 6512B9ED2617F3A4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSQMGLHPRR GLTGHWLQRF QPCLPLHTVQ WRRLLLLAFL LSLAWPASPL PREEEIVFPE 

        70         80         90        100        110        120 
KLNGSSILPG SGVPARLLYR LPAFGEMLLL ELEQDPGVQV EGLTVQYLGQ APEMLGGAEP 

       130        140        150        160        170        180 
GTYLTGTING DPESVASLHW DGGALLGVLQ YRGAELHLQP LEGGALNSAG GPGAHILRRK 

       190        200        210        220        230        240 
SPASSQGPMC TVKAPSGSPS PISRRTKRFA SLSRFVETLV VADDKMAAFH GTGLKRYLLT 

       250        260        270        280        290        300 
VMAAAAKAFK HPSIRNPVNL VVTRLVILGS GQEGPQVGPS AAQTLRSFCT WQRGLNTPND 

       310        320        330        340        350        360 
SDPDHFDTAI LFTRQDLCGV STCDTLGMAD VGTVCDPARS CAIVEDDGLQ SAFTAAHELG 

       370        380        390        400        410        420 
HVFNMLHDNS KPCTNLNGQG GSSRHVMAPV MAHVDPEEPW SPCSARFITD FLDNGYGHCL 

       430        440        450        460        470        480 
LDKPEAPLHL PATFPGKDYD ADRQCQLTFG PDSSHCPQLP PPCAALWCSG HLNGHAMCQT 

       490        500        510        520        530        540 
KHSPWADGTP CGSSQACMGG RCLHVDQLKD FNVPQAGGWG PWGPWGDCSR TCGGGVQFSS 

       550        560        570        580        590        600 
RDCTRPVPRN GGKYCEGRRT RFRSCNTENC PHGSALTFRE EQCAAYNHRT DLFKSFPGPM 

       610        620        630        640        650        660 
DWVPRYTGVA PRDQCKLTCQ ARALGYYYVL EPRVADGTPC SPDTSSVCVQ GRCIHAGCDR 

       670        680        690        700        710        720 
IIGSKKKFDK CMVCGGDGSR CSKQSGSFKK FRYGYSDVVT IPAGATHILV RQQGGSGLKS 

       730        740        750        760        770        780 
IYLALKLSDG SYALNGEYTL MPSPTDVVLP GAVSLRYSGA TAASETLSGH GPLAQPLTLQ 

       790        800        810        820        830 
VLVAGNPQNA RLRYSFFVPR PVPSTPRPPP QDWLQRRAEI LKILRKRPWA GRK 

Q8BNJ2 in FASTA format

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