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UniProtKB/Swiss-Prot entry Q8BND5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name QSOX1_MOUSE
Primary accession number Q8BND5
Secondary accession numbers Q3TDY9 Q3TE19 Q3TR29 Q3UEL4 Q8K041 Q9DBL6
Integrated into Swiss-Prot on September 19, 2006
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Sulfhydryl oxidase 1 [Precursor]
Synonyms mSOx
EC 1.8.3.2
Quiescin Q6
Skin sulfhydryl oxidase
Gene name
Name: Qsox1
Synonyms: Qscn6, Sox
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
DOI=10.1016/S0923-1811(02)00061-0; PubMed=12354420 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuba S., Suga Y., Ishidoh K., Hashimoto Y., Takamori K., Kominami E., Wilhelm B., Seitz J., Ogawa H.;
"Sulfhydryl oxidase (SOx) from mouse epidermis: molecular cloning, nucleotide sequence, and expression of recombinant protein in the cultured cells.";
J. Dermatol. Sci. 30:50-62(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
STRAIN=C57BL/6J, and NOD;
TISSUE=Cerebellum, Liver, and Spinal ganglion;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 137-538 (ISOFORM 3).
STRAIN=C57BL/6, and FVB/N;
TISSUE=Eye, and Salivary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB044284; BAB21936.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK004880; BAB23638.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK083938; BAC39073.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK149465; BAE28897.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK163119; BAE37202.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK166839; BAE39061.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169877; BAE41429.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169920; BAE41459.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK170449; BAE41807.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034131; AAH34131.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC076590; AAH76590.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001020116.1; -.
NP_075757.1; -.
UniGene Mm.27035
3D structure databases
HSSP P00274; 2TRX. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
ModBase Q8BND5.
PTM databases
PhosphoSite Q8BND5; -.
Organism-specific databases
MGI MGI:1330818; Qsox1.
Gene expression databases
ArrayExpress Q8BND5; -.
CleanEx MM_QSOX1; -.
GermOnline ENSMUSG00000033684; Mus musculus.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (inferred from sequence or structural similarity from UniProtKB).
GO:0030173; Cellular component: integral to Golgi membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0016971; Molecular function: flavin-linked sulfhydryl oxidase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0045454; Biological process: cell redox homeostasis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
GO:0006467; Biological process: protein thiol-disulfide exchange (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006863; Evr1_Alr.
IPR006662; Thioredoxin-like.
IPR013766; Thioredoxin_dom.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.
Gene3D G3DSA:1.20.120.310; Evr1_Alr; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 1.
Pfam PF04777; Evr1_Alr; 1.
PF00085; Thioredoxin; 1.
Pfam graphical view of domain structure.
PRINTS PR00421; THIOREDOXIN.
PROSITE PS51324; ERV_ALR; 1.
PS51352; THIOREDOXIN_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q8BND5.
ProtoNet Q8BND5.
Genome annotation databases
Ensembl ENSMUSG00000033684; Mus musculus. [Contig view]
GeneID 104009; -.
KEGG mmu:104009; -.
Phylogenomic databases
HOVERGEN Q8BND5; -.
Other
NextBio 356343; -.
SOURCE Qsox1; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; FAD; Flavoprotein; Glycoprotein; Golgi apparatus; Membrane; Oxidoreductase; Secreted; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    32  32     Potential. 
CHAIN   33   748  716     Sulfhydryl oxidase 1. PRO_0000249534
TRANSMEM   711   731  21     Potential. 
DOMAIN   33   159  127     Thioredoxin. 
DOMAIN   399   506  108     ERV/ALR sulfhydryl oxidase. 
CARBOHYD   133   133        N-linked (GlcNAc...) (Potential). 
CARBOHYD   246   246        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   126   154        FFQAFTKNGSGATLPGAGANVQTLRMRLI -> VCEGGATVEWFWPSTQSSVPHFPGTFLGC (in isoform 4). VSP_020491
VAR_SEQ   155   748        Missing (in isoform 4). VSP_020492
VAR_SEQ   567   568        VM -> LL (in isoform 3). VSP_020493
VAR_SEQ   569   748        Missing (in isoform 3). VSP_020494
VAR_SEQ   660   661        VN -> LL (in isoform 2). VSP_020495
VAR_SEQ   662   748        Missing (in isoform 2). VSP_020496
CONFLICT   637   637        M -> I (in Ref. 2; BAE41429). 
CONFLICT   656   656        F -> L (in Ref. 2; BAE41429). 
Sequence information
Length: 748 AA [This is the length of the unprocessed precursor] Molecular weight: 82785 Da [This is the MW of the unprocessed precursor] CRC64: 0499F6B8DAB5A8D1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRRCGRLSGP PSLLLLLLLL SPLLFSGPGA YAARLSVLYS SSDPLTLLDA DSVRPTVLGS 

        70         80         90        100        110        120 
SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA VLDCAEETNS AVCREFNIAG 

       130        140        150        160        170        180 
FPTVRFFQAF TKNGSGATLP GAGANVQTLR MRLIDALESH RDTWPPACPP LEPAKLNDID 

       190        200        210        220        230        240 
GFFTRNKADY LALVFEREDS YLGREVTLDL SQYHAVAVRR VLNTESDLVN KFGVTDFPSC 

       250        260        270        280        290        300 
YLLLRNGSVS RVPVLVESRS FYTSYLRGLP GLTRDAPPTT ATPVTADKIA PTVWKFADRS 

       310        320        330        340        350        360 
KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV QNFLHSINDW 

       370        380        390        400        410        420 
LQKQQKKRIP YSFFKAALDS RKEDAVLTEK VNWVGCQGSE PHFRGFPCSL WVLFHFLTVQ 

       430        440        450        460        470        480 
ANRYSEAHPQ EPADGQEVLQ AMRSYVQFFF GCRDCADHFE QMAAASMHQV RSPSNAILWL 

       490        500        510        520        530        540 
WTSHNRVNAR LSGALSEDPH FPKVQWPPRE LCSACHNELN GQVPLWDLGA TLNFLKAHFS 

       550        560        570        580        590        600 
PANIVIDSSA SRHTGRRGSP EATPELVMDT LKLESRNSVL GHEQAASAES PGATALDVPA 

       610        620        630        640        650        660 
EKPEASGPQE LYTGLRMGGA SPGQGPPERM EDHQRDMQEN APGQQHLSKR DTEALFLPEV 

       670        680        690        700        710        720 
NHLQGPLELR RGGRSPKQLA PILEEEPEAL AIQGQGQWLQ VLGGGISHLD ISLCVGLYSV 

       730        740 
SFMGLLAMYT YFRARLRTPK GHASYPTA 

Q8BND5 in FASTA format

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