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UniProtKB/Swiss-Prot entry Q8BHA9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACPL2_MOUSE
Primary accession number Q8BHA9
Secondary accession number Q8BZ12
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on March 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name Acid phosphatase-like protein 2 [Precursor]
Synonym EC 3.1.3.2
Gene name
Name: Acpl2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Brain cortex, Embryo, Embryonic head, Embryonic heart, Lung, and Vagina;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK036973; BAC29653.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK043758; BAC31644.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK082059; BAC38400.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK083712; BAC39001.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK084605; BAC39227.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK144699; BAE26021.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK164254; BAE37705.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC023960; AAH23960.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC036342; AAH36342.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_700469.1; -.
UniGene Mm.233031
3D structure databases
HSSP P15309; 1ND5. [HSSP ENTRY / PDB]
ModBase Q8BHA9.
Organism-specific databases
MGI MGI:2442444; Acpl2.
Gene expression databases
ArrayExpress Q8BHA9; -.
CleanEx MM_ACPL2; -.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0003993; Molecular function: acid phosphatase activity (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000560; Histidine_acid_Pase.
Graphical view of domain structure.
Pfam PF00328; Acid_phosphat_A; 1.
Pfam graphical view of domain structure.
PROSITE PS00616; HIS_ACID_PHOSPHAT_1; FALSE_NEG.
PS00778; HIS_ACID_PHOSPHAT_2; FALSE_NEG.
BLOCKS Q8BHA9.
ProtoNet Q8BHA9.
Genome annotation databases
Ensembl ENSMUSG00000043587; Mus musculus. [Contig view]
GeneID 235534; -.
KEGG mmu:235534; -.
Phylogenomic databases
HOGENOM Q8BHA9; -.
HOVERGEN Q8BHA9; -.
Other
NextBio 382737; -.
SOURCE Acpl2; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Hydrolase; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    34  34     Potential. 
CHAIN   35   480  446     Acid phosphatase-like protein 2. PRO_0000314925
ACT_SITE   97    97        Nucleophile (By similarity). 
ACT_SITE   379   379        Proton donor (By similarity). 
CARBOHYD   305   305        N-linked (GlcNAc...) (Potential). 
CONFLICT   123   123        K -> N (in Ref. 1; BAC29653). 
CONFLICT   374   374        L -> H (in Ref. 1; BAC29653). 
Sequence information
Length: 480 AA [This is the length of the unprocessed precursor] Molecular weight: 54937 Da [This is the MW of the unprocessed precursor] CRC64: 3A8E2476B9E10BB4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLHRNRFLVL LALAGLLAFL SLSLQFFHLI PVSATKNGGS SKSRKRIMPD PVTEPPTVDP 

        70         80         90        100        110        120 
VYEALLYCNI PSVAEHSMEG HAPHHYKLVS VHVFIRHGDR YPLYAIPKTK RPEIDCTLVA 

       130        140        150        160        170        180 
SRKPYHPKLE AFISHMLKGS GASFESPLNS LPLYPNHPLC ETGELTQTGV VQHLLNGQLL 

       190        200        210        220        230        240 
RDIYLRKHKL LPNNWSSDQL YLESTGKSRT LQSGLALLYG FLPEFDWKKV YFKHQPSALF 

       250        260        270        280        290        300 
CSGSCYCPLR NQYLEKEQRR QYLLRLKNSD LERTYGEMAK IVDIPTKQLR AANPIDSMLC 

       310        320        330        340        350        360 
HFCHNVSFPC SRSGCLGMEH FKVIKTHQIE DERERHEKLL YFGYSLLGAH PILNQTVNRM 

       370        380        390        400        410        420 
QRAASGWRDE LFTLYSAHDV TLSPILSALG LLEARFPRFA ARLVFELWQD RQKPSEHSVR 

       430        440        450        460        470        480 
ILYNGADVTF HTSFCHDFHK RSPKPMCPLE NLVRFVKRDM FVALDGSSTN YYDACHGEGA 

Q8BHA9 in FASTA format

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