ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8BH61


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name F13A_MOUSE
Primary accession number Q8BH61
Secondary accession numbers Q3TNF9 Q8BIP2
Integrated into Swiss-Prot on January 4, 2005
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name Coagulation factor XIII A chain [Precursor]
Synonyms Coagulation factor XIIIa
EC 2.3.2.13
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene name
Name: F13a1
Synonyms: F13a
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Bone, Cerebellum, and Spleen;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK036403; BAC29414.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK049092; BAC33539.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK165311; BAE38130.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC040274; AAH40274.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_083060.2; -.
UniGene Mm.235105
3D structure databases
HSSP P00488; 1GGU. [HSSP ENTRY / SWISS-3DIMAGE / PDB]
SMR Q8BH61; 8-727, 9-728.
ModBase Q8BH61.
PTM databases
PhosphoSite Q8BH61; -.
Organism-specific databases
MGI MGI:1921395; F13a1.
Gene expression databases
ArrayExpress Q8BH61; -.
CleanEx MM_F13A1; -.
GermOnline ENSMUSG00000039109; Mus musculus.
Ontologies
GO
GO:0003810; Molecular function: protein-glutamine gamma-glutamyltransferase activity (inferred from mutant phenotype from MGI).
GO:0007596; Biological process: blood coagulation (inferred from mutant phenotype from MGI).
GO:0018149; Biological process: peptide cross-linking (inferred from mutant phenotype from MGI).
QuickGo view.
Family and domain databases
InterPro IPR008957; Fibronectin_typ-III-like_fold.
IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.30; FN_III-like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF00927; Transglut_C; 2.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
BLOCKS Q8BH61.
Genome annotation databases
Ensembl ENSMUSG00000039109; Mus musculus. [Contig view]
GeneID 74145; -.
KEGG mmu:74145; -.
NMPDR fig|10090.3.peg.27706; -.
Phylogenomic databases
HOGENOM Q8BH61; -.
HOVERGEN Q8BH61; -.
Other
SOURCE F13a1; Mus musculus.
ProtoNet Q8BH61.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Acyltransferase; Blood coagulation; Calcium; Cytoplasm; Glycoprotein; Metal-binding; Secreted; Transferase; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
PROPEP   2    38  37     Activation peptide (By similarity). PRO_0000033648
CHAIN   39   732  694     Coagulation factor XIII A chain. PRO_0000033649
ACT_SITE   315   315        By similarity. 
ACT_SITE   374   374        By similarity. 
ACT_SITE   397   397        By similarity. 
METAL   437   437        Calcium (By similarity). 
METAL   439   439        Calcium (By similarity). 
METAL   486   486        Calcium (By similarity). 
METAL   491   491        Calcium (By similarity). 
SITE   38    39  2     Cleavage; by thrombin; to produce active factor XIII-A (By similarity). 
MOD_RES   2     2        N-acetylserine (By similarity). 
CARBOHYD   614   614        N-linked (GlcNAc...) (Potential). 
CONFLICT   5     5        P -> Q (in Ref. 1; BAC29414). 
Sequence information
Length: 732 AA [This is the length of the unprocessed precursor] Molecular weight: 83207 Da [This is the MW of the unprocessed precursor] CRC64: 47B338665D40C4D9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSDTPASTFG GRRAVPPNNS NAAEVDLPTE ELQGLVPRGV NLKDYLNVTA VHLFKERWDS 

        70         80         90        100        110        120 
NKIDHHTDKY DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF RVEYVIGRYP QENKGTYIPV 

       130        140        150        160        170        180 
PVVKELQSGK WGAKVIMNED RSVRLSVQSS PECIVGKFRM YVAVWTPYGI LRTRRDPETD 

       190        200        210        220        230        240 
TYILFNPWCE EDAVYLDDEK EREEYVLNDI GVIFYGDFKD IKSRSWSYGQ FEDGILDTCL 

       250        260        270        280        290        300 
YVMDKAEMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 

       310        320        330        340        350        360 
LEYRSSETPV RYGQCWVFAG VFNTFLRCLG IPARVITNYF SAHDNDANLQ MDIFLEEDGN 

       370        380        390        400        410        420 
VSSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAVKH 

       430        440        450        460        470        480 
GHVCFQFDAP FVFAEVNSDL VYITAKQDGT HVVEAVDATH IGKLIVTKQI GGDGMQDITD 

       490        500        510        520        530        540 
TYKFQEGQEE ERLALETALM YGAKKTLNTE GVVKSRSDVT MNFDVENAVL GKDFKVTITF 

       550        560        570        580        590        600 
QNNSSNLYTI LAYLSGNITF YTGVSKKEFK KESFEETLDP FSSKKKEVLV RAGEYMSHLL 

       610        620        630        640        650        660 
EQGFLHFFVT ARINESRDVL AKQKSIILTI PKITIKVRGA AMVGSDMVVT VEFTNPLKET 

       670        680        690        700        710        720 
LQNVWIHLDG PGVMRPKRKV FREIRPNTTV QWEEVCRPWV SGHRKLIASM TSDSLRHVYG 

       730 
ELDLQIQRRP TM 

Q8BH61 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!