ID   PYRB_BACTN              Reviewed;         313 AA.
AC   Q8A9S3;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-NOV-2008, entry version 45.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=BT_0742;
OS   Bacteroides thetaiotaomicron.
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=818;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
RX   MEDLINE=22550858; PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K.,
RA   Chiang H.C., Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; AE015928; AAO75849.1; -; Genomic_DNA.
DR   RefSeq; NP_809655.1; -.
DR   GeneID; 1073579; -.
DR   GenomeReviews; AE015928_GR; BT_0742.
DR   KEGG; bth:BT_0742; -.
DR   NMPDR; fig|226186.1.peg.742; -.
DR   HOGENOM; Q8A9S3; -.
DR   BioCyc; BTHE226186:BT_0742-MON; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006130; Asp/Orn_carbamoyltranf.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    313       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000113100.
SQ   SEQUENCE   313 AA;  36188 MW;  F46C8838BC58BA47 CRC64;
     MENRSLVTIA EHSKEKILYM LEMAKQFEMN PNRRLLQGKV VATLFFEPST RTRLSFETAA
     NRLGARVIGF TDPKATSSSK GETLKDTIMM VSSYADIIVM RHYLEGAARY ASEVAPVPIV
     NAGDGANQHP SQTMLDLYSI YKTQGTLENL NIFLVGDLKY GRTVHSLLMA MRHFNPTFHF
     IAPDELKMPE EYKLYCKEHQ IKYIEHTEFT EEIIADADIL YMTRVQRERF TDLMEYERVK
     NVYILRNKML ENTRPNLRIL HPLPRVNEIA YDVDNNPKAY YFQQAQNGLY AREAILCDVL
     GITLEDVKND ILL
//