NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).

Comments

CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate.
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 2/6 .
SIMILARITY: Belongs to the ATCase/OTCase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE015928; AAO75849.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_809655.1; -.

3D structure databases

ModBase

Q8A9S3.

Enzyme and pathway databases

BioCyc

BTHE226186:BT_0742-MON; -.

Ontologies

GO:0004070;	Molecular function: aspartate carbamoyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0006221;	Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00001; -; 1.
PBIL [Tree]

InterPro

IPR006130; Asp/Orn_carbamoyltranf.
IPR006132; Asp/Orn_carbamoyltranf_P_bd.
IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
IPR002082; Aspartate_carbamoyltransf_euk.
Graphical view of domain structure.

Pfam

PF00185; OTCace; 1.
PF02729; OTCace_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR00100; AOTCASE.
PR00101; ATCASE.

TIGRFAMs

TIGR00670; asp_carb_tr; 1.

PROSITE

PS00097; CARBAMOYLTRANSFERASE; 1.

BLOCKS

Q8A9S3.

Genome annotation databases

GeneID

1073579; -.

GenomeReviews

AE015928_GR; BT_0742.

KEGG

bth:BT_0742; -.

NMPDR

fig|226186.1.peg.742; -.

Phylogenomic databases

HOGENOM

Q8A9S3; -.

Genome annotation databases

CMR

Q8A9S3; BT_0742.

Other

ProtoNet

Q8A9S3.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Pyrimidine biosynthesis; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 313`	`313`		`Aspartate carbamoyltransferase.`	`PRO_0000113100`

Sequence information

Length: 313 AA [This is the length of the unprocessed precursor]

Molecular weight: 36188 Da [This is the MW of the unprocessed precursor]

CRC64: F46C8838BC58BA47 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MENRSLVTIA EHSKEKILYM LEMAKQFEMN PNRRLLQGKV VATLFFEPST RTRLSFETAA 

        70         80         90        100        110        120 
NRLGARVIGF TDPKATSSSK GETLKDTIMM VSSYADIIVM RHYLEGAARY ASEVAPVPIV 

       130        140        150        160        170        180 
NAGDGANQHP SQTMLDLYSI YKTQGTLENL NIFLVGDLKY GRTVHSLLMA MRHFNPTFHF 

       190        200        210        220        230        240 
IAPDELKMPE EYKLYCKEHQ IKYIEHTEFT EEIIADADIL YMTRVQRERF TDLMEYERVK 

       250        260        270        280        290        300 
NVYILRNKML ENTRPNLRIL HPLPRVNEIA YDVDNNPKAY YFQQAQNGLY AREAILCDVL 

       310 
GITLEDVKND ILL

Q8A9S3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools