NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).

Comments

FUNCTION: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
COFACTOR: Divalent cations (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the HAM1 NTPase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE015928; AAO78234.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_812040.1; -.

3D structure databases

HSSP

Q57679; 1B78. [HSSP ENTRY / PDB]

ModBase

Q8A327.

Enzyme and pathway databases

BioCyc

BTHE226186:BT_3128-MON; -.

Ontologies

GO:0017111;	Molecular function: nucleoside-triphosphatase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01405; -; 1.
PBIL [Tree]

InterPro

IPR002637; Ham1p_like.
Graphical view of domain structure.

PANTHER

PTHR11067; Ham1p_like; 1.

Pfam

PF01725; Ham1p_like; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00042; Ham1p_like; 1.

BLOCKS

Q8A327.

Genome annotation databases

GeneID

1075977; -.

GenomeReviews

AE015928_GR; BT_3128.

KEGG

bth:BT_3128; -.

NMPDR

fig|226186.1.peg.3127; -.

Phylogenomic databases

HOGENOM

Q8A327; -.

Genome annotation databases

CMR

Q8A327; BT_3128.

Other

ProtoNet

Q8A327.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Hydrolase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 193`	`193`		`Nucleoside-triphosphatase.`	`PRO_0000178130`

Sequence information

Length: 193 AA [This is the length of the unprocessed precursor]

Molecular weight: 21656 Da [This is the MW of the unprocessed precursor]

CRC64: 75D3C83E9C81185B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKRKLVFATN NAHKLEEIAA ILGDKVELLS LNDIDCHTDI PETAETLEGN ALLKSSFIYR 

        70         80         90        100        110        120 
NYQLDCFADD TGLEVEALNG APGVYSARYA EGEGHDAQAN MRKLLHELEG KENRKAQFRT 

       130        140        150        160        170        180 
AISLILDGKE YLFEGVIKGE IIKEKRGDSG FGYDPIFKPE GYEQTFAELG NETKNKISHR 

       190 
ALAVQKLCEF LQR

Q8A327 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools