NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).

Comments

CATALYTIC ACTIVITY: D-glyceraldehyde 3-phosphate = glycerone phosphate.
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis .
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1 .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the triosephosphate isomerase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE015928; AAO79034.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_812840.1; -.

3D structure databases

HSSP

P00940; 1TPH. [HSSP ENTRY / SWISS-3DIMAGE / PDB]

ModBase

Q8A0U2.

Enzyme and pathway databases

BioCyc

BTHE226186:BT_3929-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004807;	Molecular function: triose-phosphate isomerase activity (inferred from electronic annotation from HAMAP).
GO:0006094;	Biological process: gluconeogenesis (inferred from electronic annotation from HAMAP).
GO:0006096;	Biological process: glycolysis (inferred from electronic annotation from HAMAP).
GO:0006098;	Biological process: pentose-phosphate shunt (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00147; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR000652; Triophos_ismrse.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

PANTHER

PTHR21139; Triophos_ismrse; 1.

Pfam

PF00121; TIM; 1.
Pfam graphical view of domain structure.

ProDom

PD001005; Triophos_ismrse; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGR00419; tim; 1.

PS00171; TIM; 1.

Genome annotation databases

GeneID

1071892; -.

GenomeReviews

AE015928_GR; BT_3929.

KEGG

bth:BT_3929; -.

NMPDR

fig|226186.1.peg.3927; -.

Phylogenomic databases

HOGENOM

Q8A0U2; -.

Genome annotation databases

CMR

Q8A0U2; BT_3929.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Pentose shunt.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 252`	`252`	`Triosephosphate isomerase.`	`PRO_0000090180`
`ACT_SITE`	`96 96`		`Electrophile (By similarity).`
`ACT_SITE`	`167 167`		`Proton acceptor (By similarity).`
`BINDING`	`9 9`		`Substrate (By similarity).`
`BINDING`	`11 11`		`Substrate (By similarity).`

Sequence information

Length: 252 AA [This is the length of the unprocessed precursor]

Molecular weight: 26802 Da [This is the MW of the unprocessed precursor]

CRC64: D61D75B93646FA4E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MRKNIVAGNW KMNKTLQEGI ALAKELNEAL ANEKPNCDVI ICTPFIHLAS VTPLVDAAKI 

        70         80         90        100        110        120 
GVGAENCADK ASGAYTGEVS AEMVASTGAK YVILGHSERR AYYGETVAIL EEKVKLALAN 

       130        140        150        160        170        180 
GLTPIFCIGE VLEEREANKQ NEVVAAQMES VFSLSAEDFS KIILAYEPVW AIGTGKTASP 

       190        200        210        220        230        240 
EQAQEIHAFI RSIVADKYGK EIADNTSILY GGSCKPSNAK ELFSNPDVDG GLIGGAALKV 

       250 
SDFKGIIDAF NA

Q8A0U2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools