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UniProtKB/Swiss-Prot entry Q8A0U0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCH1_BACTN
Primary accession number Q8A0U0
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 45)
Name and origin of the protein
Protein name GTP cyclohydrolase 1
Synonyms EC 3.5.4.16
GTP cyclohydrolase I
GTP-CH-I
Gene name
Name: folE
OrderedLocusNames: BT_3931
From
Bacteroides thetaiotaomicron [TaxID: 818] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015928; AAO79036.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_812842.1; -.
3D structure databases
HSSP P30793; 1FB1. [HSSP ENTRY / PDB]
ModBase Q8A0U0.
Enzyme and pathway databases
BioCyc BTHE226186:BT_3931-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0003934; Molecular function: GTP cyclohydrolase I activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0019438; Biological process: aromatic compound biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
GO:0046654; Biological process: tetrahydrofolate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00223; -; 1.
PBIL [Tree]
InterPro IPR001474; GTP_CycOHase_I.
Graphical view of domain structure.
PANTHER PTHR11109; GTP_cyclohydro_I; 1.
Pfam PF01227; GTP_cyclohydroI; 1.
Pfam graphical view of domain structure.
ProDom PD003330; GTP_cyclohydroI; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00063; folE; 1.
PROSITE PS00859; GTP_CYCLOHYDROL_1_1; 1.
PS00860; GTP_CYCLOHYDROL_1_2; 1.
BLOCKS Q8A0U0.
ProtoNet Q8A0U0.
Genome annotation databases
GeneID 1073052; -.
GenomeReviews AE015928_GR; BT_3931.
KEGG bth:BT_3931; -.
NMPDR fig|226186.1.peg.3929; -.
Phylogenomic databases
HOGENOM Q8A0U0; -.
Genome annotation databases
CMR Q8A0U0; BT_3931.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; One-carbon metabolism; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   196  196     GTP cyclohydrolase 1. PRO_0000119387
METAL   85    85        Zinc (By similarity). 
METAL   88    88        Zinc (By similarity). 
METAL   156   156        Zinc (By similarity). 
Sequence information
Length: 196 AA [This is the length of the unprocessed precursor] Molecular weight: 22452 Da [This is the MW of the unprocessed precursor] CRC64: 70C8D82D36975990 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLEKEEIVSP NLEELKSHYH SIITLLGEDA GREGLLKTPE RVAKAMLSLT KGYHMDPHEV 

        70         80         90        100        110        120 
LRSAKFQEEY SQMVIVKDID FFSLCEHHML PFYGKAHVAY IPNGYITGLS KIARVVDIFS 

       130        140        150        160        170        180 
HRLQVQERMT LQIKDCIQET LNPLGVMVVV EAKHMCMQMR GVEKQNSITT TSDFTGAFNQ 

       190 
AKTREEFMNL IQHGRV
Q8A0U0 in FASTA format

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