NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).

Comments

FUNCTION: Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity).
CATALYTIC ACTIVITY: A 5'-ribonucleotide + H₂O = a ribonucleoside + phosphate.
COFACTOR: Binds 1 divalent metal cation per subunit (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (Potential).
SIMILARITY: Belongs to the surE nucleotidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE015928; AAO79108.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_812914.1; -.

3D structure databases

HSSP

P96112; 1J9L. [HSSP ENTRY / PDB]

ModBase

Q8A0L8.

Enzyme and pathway databases

BioCyc

BTHE226186:BT_4003-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008253;	Molecular function: 5'-nucleotidase activity (inferred from electronic annotation from HAMAP).
GO:0046872;	Molecular function: metal ion binding (inferred from electronic annotation from HAMAP).
GO:0000166;	Molecular function: nucleotide binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_00060; -; 1.
PBIL [Tree]

InterPro

IPR002828; SurE-like_Pase/nucleotidase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.1210.10; SurE-like_Pase/nucleotidase; 1.

Pfam

PF01975; SurE; 1.
Pfam graphical view of domain structure.

ProDom

PD005378; SurE; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGR00087; surE; 1.

Genome annotation databases

GeneID

1074660; -.

GenomeReviews

AE015928_GR; BT_4003.

KEGG

bth:BT_4003; -.

NMPDR

fig|226186.1.peg.4001; -.

Phylogenomic databases

HOGENOM

Q8A0L8; -.

Genome annotation databases

CMR

Q8A0L8; BT_4003.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleotide-binding.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 259`	`259`	`5'-nucleotidase surE.`	`PRO_0000111789`
`METAL`	`13 13`		`Divalent metal cation (By similarity).`
`METAL`	`14 14`		`Divalent metal cation (By similarity).`
`METAL`	`44 44`		`Divalent metal cation (By similarity).`
`METAL`	`100 100`		`Divalent metal cation (By similarity).`

Sequence information

Length: 259 AA [This is the length of the unprocessed precursor]

Molecular weight: 28365 Da [This is the MW of the unprocessed precursor]

CRC64: CF226096DE40B251 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MESKKPLILV SNDDGVMAKG ISELVKFLRP LGEIVVMAPD SPRSGSGSAL TVTHPVHYQL 

        70         80         90        100        110        120 
VKREVGLTVY KCTGTPTDCI KLALGSVLDR KPDLIVGGIN HGDNSAINVH YSGTMGVVIE 

       130        140        150        160        170        180 
GCLKGIPSIG FSLCNHRPDA DFEPSGPYIR KIAAMILEKG LPPLTCLNVN FPDTPNLKGV 

       190        200        210        220        230        240 
KVCEQAKGCW VNEWVTCPRL DDHNYFWLTG SFTDHELENE NNDHWALENG YVAITPTTVD 

       250 
MTAYGFIDEL NGYCQQLEF

Q8A0L8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools