NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482;
DOI=10.1126/science.1080029; PubMed=12663928 [NCBI, ExPASy, EBI, Israel, Japan]
Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C., Hooper L.V., Gordon J.I.;
"A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
Science 299:2074-2076(2003).

Comments

FUNCTION: The glycine cleavage system catalyzes the degradation of glycine (By similarity).
CATALYTIC ACTIVITY: [Protein]-S⁸-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH₃.
SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity).
SIMILARITY: Belongs to the gcvT family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE015928; AAO79689.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_813495.1; -.

3D structure databases

ModBase

Q89YZ6.

Enzyme and pathway databases

BioCyc

BTHE226186:BT_4584-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0004047;	Molecular function: aminomethyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008483;	Molecular function: transaminase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0019464;	Biological process: glycine decarboxylation via glycine cleavage system (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00259; -; 1.
PBIL [Tree]

InterPro

IPR013977; GCV_T_C.
IPR006222; GCV_T_N.
IPR006223; GcvT.
Graphical view of domain structure.

Pfam

PF01571; GCV_T; 1.
PF08669; GCV_T_C; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF006487; GcvT; 1.

TIGR00528; gcvT; 1.

Genome annotation databases

GeneID

1073159; -.

GenomeReviews

AE015928_GR; BT_4584.

KEGG

bth:BT_4584; -.

NMPDR

fig|226186.1.peg.4582; -.

Phylogenomic databases

HOGENOM

Q89YZ6; -.

Genome annotation databases

CMR

Q89YZ6; BT_4584.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Aminotransferase; Complete proteome; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 361`	`361`		`Aminomethyltransferase.`	`PRO_0000122544`

Sequence information

Length: 361 AA [This is the length of the unprocessed precursor]

Molecular weight: 39826 Da [This is the MW of the unprocessed precursor]

CRC64: C57E87A164F95A89 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKTTPFTEKH IALGAKMHEF AGYNMPIEYS GIIDEHLTVC NAVGVFDVSH MGEFWVKGPQ 

        70         80         90        100        110        120 
ALAFLQKVTS NNVAALVPGK IQYTCFPNEE GGIVDDLLVY CYEPEKYLLV VNAANIEKDW 

       130        140        150        160        170        180 
NWCVSHNTEG AELENSSDNM AQLAVQGPKA ILALQKLTDI DLSAIPYYTF TVGRFAGKEN 

       190        200        210        220        230        240 
VIISNTGYTG AGGFELYFYP DAAEAIWKAV FEAGEEFGIK PVGLGARDTL RLEMGFCLYG 

       250        260        270        280        290        300 
NDLDDKTSPI EAGLGWITKF VEGKEFINRP MLEKQKSEGT TRKLVGFEMI DRGIPRHGYE 

       310        320        330        340        350        360 
LVNEEGEGIG VVTSGTMSPT RKIGIGMGYV KPEYAKVGTE ICIDMRGRKL KAIVVKPPFR 


K

Q89YZ6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools