NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=USDA 110;
DOI=10.1093/dnares/9.6.189; PubMed=12597275 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.";
DNA Res. 9:189-197(2002).

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000040; BAC48291.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_769666.1; -.

3D structure databases

ModBase

Q89QU8.

Enzyme and pathway databases

BioCyc

BJAP224911:BLR3026-MON; -.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR003141; PHP_N.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

SMART

SM00481; POLIIIAc; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

Q89QU8.

Genome annotation databases

GeneID

1053315; -.

GenomeReviews

BA000040_GR; blr3026.

KEGG

bja:blr3026; -.

NMPDR

fig|224911.1.peg.3026; -.

Phylogenomic databases

HOGENOM

Q89QU8; -.

Genome annotation databases

CMR

Q89QU8; blr3026.

Other

ProtoNet

Q89QU8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1151`	`1151`		`Error-prone DNA polymerase.`	`PRO_0000103369`

Sequence information

Length: 1151 AA [This is the length of the unprocessed precursor]

Molecular weight: 129582 Da [This is the MW of the unprocessed precursor]

CRC64: 2F0563C7FC4625A7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNTPAYAEIG ITTNFSFLRG GSDPRAYVHQ ASILGISAIG IADHNTLAGV VRAYKELDND 

        70         80         90        100        110        120 
KVLHKPKLLI GARIVFIDGT PDILVYPRDR AAYGRLCQLL TRGKRGDDVT RIEKGECRLT 

       130        140        150        160        170        180 
FSDLLAFSEG QLLVLTLPHR FEPAQALDVL AKLKATRAEG VWLAASLVHR GDDRRRLARL 

       190        200        210        220        230        240 
DDLATTAKVQ LLATNEVLYH DPARRPLQDV LTCIREKTTI EAVGRKLEAN AERFLKTPRE 

       250        260        270        280        290        300 
MSRLFRDFPD AIAETMRFAN KIDFSLDQLR YQYPDEPVPP GKTAQGHLED LTWAGVDKYF 

       310        320        330        340        350        360 
AGKIDDKLRA TLKKELALIA ELKYAHYFLT VHDIVHYARS QNILCQGRGS AANSAVCYVL 

       370        380        390        400        410        420 
GITSVDPTKV DLLFERFISK ERLEPPDIDV DFEHSRREEV MQYVYRRYGR HRAAIIATII 

       430        440        450        460        470        480 
HYRPRSAIRD VGKALGLTED VTAALADTVW GSWGSGLNDM QVKQAGLDPQ NPMINLAVEL 

       490        500        510        520        530        540 
ATELIEFPRH LSQHVGGYVL TQDRLDTYVP IGNAAMDDRT FIEWDKDDVD ALNMMKVDVL 

       550        560        570        580        590        600 
ALGMLTCIRK CFDLIDQHKG ERWVLASVPQ DDPKVYDMLC DGESLGVFQV ESRAQMNMLP 

       610        620        630        640        650        660 
RLKPRTFYDL VIEVAIVRPG PIQGDMVHPY LRRRNGQEKV NYPSPSPEHG PADELYKVLH 

       670        680        690        700        710        720 
KTKGVPLFQE QAMRIAIEAA KFTSEEANGL RRSMATFRNV GTIGKYEDKL IGNMVARGYD 

       730        740        750        760        770        780 
PNFARSCFDQ IKGFGSYGFP ESHAASFAQL VYISSWLKYH HPDAFCCGLL NSQPMGFYAP 

       790        800        810        820        830        840 
AQIVGDARKN GVEVRDIDVS YSFAQNTLEQ GSGKYCAVRL GFRQIDGFHW LDEDEEHLKR 

       850        860        870        880        890        900 
SLLSFRGAPL GANPESIGPH MPGGMDSGLD AGASPRNDKK EDWANRIVAA RNRRPFTSLE 

       910        920        930        940        950        960 
DFARDTGLPK RALILLADAD AFRSLGLDRR EALWQVRRLP DDVPLPLFEA ATAREQPDEH 

       970        980        990       1000       1010       1020 
AKPLPLMPRP EQVVADYQTI RLSLKGHPME FLREMLSRER VVACKDVNHQ NERRRVRCAG 

      1030       1040       1050       1060       1070       1080 
VVLVRQRPGS ASGVVFMTLE DETGIANVVV WPKIMEQYRK EVMGARLILV EGYIQSSPEK 

      1090       1100       1110       1120       1130       1140 
VTHLIAQRMV DRSHDLIGLA NDSLTRKHPV PSGDALIEPL NDDRRDHADA PAQKIRHPRN 

      1150 
VRILPPSRDF H

Q89QU8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools