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UniProtKB/Swiss-Prot entry Q89IW2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCH1_BRAJA
Primary accession number Q89IW2
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 40)
Name and origin of the protein
Protein name GTP cyclohydrolase 1
Synonyms EC 3.5.4.16
GTP cyclohydrolase I
GTP-CH-I
Gene name
Name: folE
OrderedLocusNames: bll5522
From
Bradyrhizobium japonicum [TaxID: 375] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=USDA 110;
DOI=10.1093/dnares/9.6.189; PubMed=12597275 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.";
DNA Res. 9:189-197(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000040; BAC50787.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_772162.1; -.
3D structure databases
HSSP P22288; 1IS8. [HSSP ENTRY / PDB]
ModBase Q89IW2.
Enzyme and pathway databases
BioCyc BJAP224911:BLL5522-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0003934; Molecular function: GTP cyclohydrolase I activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0019438; Biological process: aromatic compound biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
GO:0046654; Biological process: tetrahydrofolate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00223; -; 1.
PBIL [Tree]
InterPro IPR001474; GTP_CycOHase_I.
Graphical view of domain structure.
PANTHER PTHR11109; GTP_cyclohydro_I; 1.
Pfam PF01227; GTP_cyclohydroI; 1.
Pfam graphical view of domain structure.
ProDom PD003330; GTP_cyclohydroI; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00063; folE; 1.
PROSITE PS00859; GTP_CYCLOHYDROL_1_1; 1.
PS00860; GTP_CYCLOHYDROL_1_2; FALSE_NEG.
BLOCKS Q89IW2.
ProtoNet Q89IW2.
Genome annotation databases
GeneID 1051113; -.
GenomeReviews BA000040_GR; bll5522.
KEGG bja:bll5522; -.
NMPDR fig|224911.1.peg.5522; -.
Phylogenomic databases
HOGENOM Q89IW2; -.
Genome annotation databases
CMR Q89IW2; bll5522.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; One-carbon metabolism; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   229  229     GTP cyclohydrolase 1. PRO_0000119389
METAL   118   118        Zinc (By similarity). 
METAL   121   121        Zinc (By similarity). 
METAL   189   189        Zinc (By similarity). 
Sequence information
Length: 229 AA [This is the length of the unprocessed precursor] Molecular weight: 25543 Da [This is the MW of the unprocessed precursor] CRC64: 0D27E16783188A51 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDATIKSIRP SKPSDRQPES RPAELDPAEF LAAAVRADQP RPARAQAEAA VKTLLAYIGE 

        70         80         90        100        110        120 
NTEREGLLDT PRRVVEAFDE LYQGYHQCPA EVLDRTFGET AGYDDFVLVR DIEFTSQCEH 

       130        140        150        160        170        180 
HMMPFYGKAH IAYTPVERVV GLSKLARLTD IFARRLQTQE HLTAQIAAAI DEVLKPRGVA 

       190        200        210        220 
VLIEAEHTCM SVRGVAKHGA STFTSRFTGM FRDNPAEQAR FLSLVRGTR
Q89IW2 in FASTA format

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