NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=USDA 110;
DOI=10.1093/dnares/9.6.189; PubMed=12597275 [NCBI, ExPASy, EBI, Israel, Japan]
Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
"Complete genomic sequence of nitrogen-fixing symbiotic bacterium Bradyrhizobium japonicum USDA110.";
DNA Res. 9:189-197(2002).

Comments

CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5 .
SIMILARITY: Belongs to the SAICAR synthetase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000040; BAC50994.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_772369.1; -.

3D structure databases

HSSP

Q9X0X0; 1KUT. [HSSP ENTRY / PDB]

ModBase

Q89IB0.

Enzyme and pathway databases

BioCyc

BJAP224911:BLL5729-MON; -.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004639;	Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (inferred from electronic annotation from HAMAP).
GO:0006164;	Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00137; -; 1.
PBIL [Tree]

InterPro

IPR013816; ATP_grasp_subdomain_2.
IPR001636; SAICAR_synt.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.

PANTHER

PTHR11609; SAICAR_synt; 1.

Pfam

PF01259; SAICAR_synt; 1.
Pfam graphical view of domain structure.

ProDom

PD003043; SAICAR_synt; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00081; purC; 1.

PROSITE

PS01057; SAICAR_SYNTHETASE_1; 1.
PS01058; SAICAR_SYNTHETASE_2; FALSE_NEG.

Genome annotation databases

GeneID

1048812; -.

GenomeReviews

BA000040_GR; bll5729.

KEGG

bja:bll5729; -.

NMPDR

fig|224911.1.peg.5729; -.

Phylogenomic databases

HOGENOM

Q89IB0; -.

Genome annotation databases

CMR

Q89IB0; bll5729.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Ligase; Purine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 255`	`255`		`Phosphoribosylaminoimidazole-succinocarboxamide synthase A.`	`PRO_0000100807`

Sequence information

Length: 255 AA [This is the length of the unprocessed precursor]

Molecular weight: 29186 Da [This is the MW of the unprocessed precursor]

CRC64: 961AB39593EEBF19 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSRRRRIYEG KAKVLYEGPE PGTLIQHFKD DATAFNAKKH QVIEGKGVLN NRISEYLFQH 

        70         80         90        100        110        120 
LNDIGVPTHF IRRLNMREQL IREVEIVPLE VVVRNVAAGS LSQRLGIEEG TQLPRSIIEF 

       130        140        150        160        170        180 
YYKNDQLNDP MVSEEHITAF GWATPQEIDD IMALAIRVND FLTGLFLGIG IRLVDFKMEC 

       190        200        210        220        230        240 
GRLFENEMMR IIVADEISPD SCRLWDIKSN EKLDKDRFRR DLGGLLEAYT EVAKRLGILM 

       250 
ENERPAGSGP VLVKS

Q89IB0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools