ID   ILVC_BRAJA              Reviewed;         339 AA.
AC   Q89G50;
DT   06-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   06-JUN-2003, sequence version 1.
DT   25-NOV-2008, entry version 38.
DE   RecName: Full=Ketol-acid reductoisomerase;
DE            EC=1.1.1.86;
DE   AltName: Full=Acetohydroxy-acid isomeroreductase;
DE   AltName: Full=Alpha-keto-beta-hydroxylacil reductoisomerase;
GN   Name=ilvC; OrderedLocusNames=bll6497;
OS   Bradyrhizobium japonicum.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=375;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USDA 110;
RX   MEDLINE=22484998; PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T.,
RA   Sasamoto S., Watanabe A., Idesawa K., Iriguchi M., Kawashima K.,
RA   Kohara M., Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M.,
RA   Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+)
CC       = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.
CC   -!- CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate +
CC       NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-
CC       isoleucine from 2-oxobutanoate: step 2/4.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine
CC       from pyruvate: step 2/4.
CC   -!- SIMILARITY: Belongs to the ketol-acid reductoisomerase family.
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DR   EMBL; BA000040; BAC51762.1; -; Genomic_DNA.
DR   RefSeq; NP_773137.1; -.
DR   HSSP; Q9HVA2; 1NP3.
DR   SMR; Q89G50; 1-328.
DR   GeneID; 1047317; -.
DR   GenomeReviews; BA000040_GR; bll6497.
DR   KEGG; bja:bll6497; -.
DR   NMPDR; fig|224911.1.peg.6497; -.
DR   HOGENOM; Q89G50; -.
DR   BioCyc; BJAP224911:BLL6497-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004455; F:ketol-acid reductoisomerase activity; IEA:HAMAP.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009099; P:valine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00435; -; 1.
DR   InterPro; IPR013023; AcH_isomrdctse.
DR   InterPro; IPR000506; AcH_isomrdctse_C.
DR   InterPro; IPR013116; IlvN.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR21371; AcH_isomrdctse; 1.
DR   Pfam; PF01450; IlvC; 1.
DR   Pfam; PF07991; IlvN; 1.
DR   TIGRFAMs; TIGR00465; ilvC; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    339       Ketol-acid reductoisomerase.
FT                                /FTId=PRO_0000151283.
FT   ACT_SITE    108    108       Potential.
SQ   SEQUENCE   339 AA;  36887 MW;  E221BDAEA58AF8B5 CRC64;
     MRVYYDRDAD LNLIKGKKVA IVGYGSQGHA HALNLKDSGV KEVAIALRKD SSSVKKAEAA
     GFKVMDVAEA AKWADLVMML TPDELQGDIY REHLHDNMKK GAALVFAHGL NVHFNLLDPR
     ADLDVLMIAP KGPGHTVRSE YQRGGGVPCL IAIAKDVSGN AHDLGLSYAS AVGGGRAGII
     ETTFKEECET DLFGEQVVLC GGLVELIKGG YETLVEAGYA PEMAYFECLH EVKLIVDLIY
     EGGIANMNYS ISNTAEYGEY VTGPRIVTAE TKAEMKRVLA DIQGGKFARD WMLENKVNQT
     SFKATRAKLA AHPIEEVGAK LRDMMPWIKK GALVDKSKN
//