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UniProtKB/Swiss-Prot entry Q89B13

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name METF_BUCBP
Primary accession number Q89B13
Secondary accession numbers None
Integrated into Swiss-Prot on November 7, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 35)
Name and origin of the protein
Protein name 5,10-methylenetetrahydrofolate reductase
Synonym EC 1.5.1.20
Gene name
Name: metF
OrderedLocusNames: bbp_047
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO26786.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777681.1; -.
3D structure databases
HSSP P00394; 1B5T. [HSSP ENTRY / PDB]
ModBase Q89B13.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_047-MON; -.
Ontologies
GO
GO:0004489; Molecular function: methylenetetrahydrofolate reductase (NADPH) activity (inferred from electronic annotation from InterPro).
GO:0009086; Biological process: methionine biosynthetic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR003171; Mehydrof_redctse.
IPR004620; MTHF_reductase_bac.
Graphical view of domain structure.
Pfam PF02219; MTHFR; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00676; fadh2; 1.
BLOCKS Q89B13.
ProtoNet Q89B13.
Genome annotation databases
GeneID 1058532; -.
GenomeReviews AE016826_GR; bbp_047.
KEGG bab:bbp047; -.
Phylogenomic databases
HOGENOM Q89B13; -.
Genome annotation databases
CMR Q89B13; bbp_047.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; FAD; Flavoprotein; Methionine biosynthesis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   295  295     5,10-methylenetetrahydrofolate reductase. PRO_0000190260
Sequence information
Length: 295 AA [This is the length of the unprocessed precursor] Molecular weight: 33770 Da [This is the MW of the unprocessed precursor] CRC64: D34F60F04D44AED3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKLVYKNYHE TLNQHLMNIC EKVNISFEFF PPNNILSEKN LWQVIDKLKL LTPKFFSVTH 

        70         80         90        100        110        120 
GTNSKIRATC TSNIVKKIKK YTGIETVPHL TCINSTEEEL KVIAKTYWDS GIRHILALRG 

       130        140        150        160        170        180 
DIFNTNCKPK IYAVDLIKLL KSIANFEISV AAYPEVHPEA VNAKYDIINL KRKVEAGATR 

       190        200        210        220        230        240 
AITQFFFNID CFLRFRDLCV KNNITIDIVP GIFPISNFKQ LLKFSSVSNV SIPKWLCCMF 

       250        260        270        280        290 
HGLDNDLNTS RIIGSSIAID MVKVLYSEGI RSFHFYTLNK SEISFAICKI LENKS
Q89B13 in FASTA format

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