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UniProtKB/Swiss-Prot entry Q89AX6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HIS2_BUCBP
Primary accession number Q89AX6
Secondary accession numbers None
Integrated into Swiss-Prot on June 16, 2003
Sequence was last modified on June 16, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 40)
Name and origin of the protein
Protein name Histidine biosynthesis bifunctional protein hisIE
Synonyms None
Includes Phosphoribosyl-AMP cyclohydrolase
     (PRA-CH)
     (EC 3.5.4.19)
Phosphoribosyl-ATP pyrophosphatase
     (PRA-PH)
     (EC 3.6.1.31)
Gene name
Name: hisI
Synonyms: hisIE
OrderedLocusNames: bbp_100
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO26835.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777730.1; -.
3D structure databases
ModBase Q89AX6.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_100-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01019; -; 1.
PBIL [Tree]
InterPro IPR002496; PRA_CycOHase.
IPR008179; PRib-ATP_pyrophosphohydrolase.
Graphical view of domain structure.
Pfam PF01502; PRA-CH; 1.
PF01503; PRA-PH; 1.
Pfam graphical view of domain structure.
ProDom PD002610; PRA_cyclohydro; 1.
PD002611; Pra_PH/CH; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03188; histidine_hisI; 1.
BLOCKS Q89AX6.
ProtoNet Q89AX6.
Genome annotation databases
GeneID 1058395; -.
GenomeReviews AE016826_GR; bbp_100.
KEGG bab:bbp100; -.
Phylogenomic databases
HOGENOM Q89AX6; -.
Genome annotation databases
CMR Q89AX6; bbp_100.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   206  206     Histidine biosynthesis bifunctional protein hisIE. PRO_0000136407
REGION   1   114  114     Phosphoribosyl-AMP cyclohydrolase. 
REGION   115   206  92     Phosphoribosyl-ATP pyrophosphohydrolase. 
Sequence information
Length: 206 AA [This is the length of the unprocessed precursor] Molecular weight: 23962 Da [This is the MW of the unprocessed precursor] CRC64: 2E08D659425DE50B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLKKINFIDI NWNKVDNMLP VVIQHNLSGK VLMHGYMNQE ALKRTQNEGI VTFYSRTKQR 

        70         80         90        100        110        120 
LWTKGETSKN FLYVTDIRLD CDQDALLIFV RPVGKTCHLN HVSCFQVPSE NLFFLHDLDC 

       130        140        150        160        170        180 
MLKFKKHYGL ENSYTFNLHK NGVNRIAQKV AEEAIETAIS AVSKNKVELI NESSDLVYHL 

       190        200 
LVLLHSYDLD LYDVIKNLKM RSNKQV
Q89AX6 in FASTA format

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