FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).
CATALYTIC ACTIVITY: NADH + quinone = NAD⁺ + quinol.
SUBUNIT: Composed of 13 different subunits. Subunits nuoCD, E, F, and G constitute the peripheral sector of the complex (By similarity).
SIMILARITY: In the N-terminal section; belongs to the complex I 30 kDa subunit family.
SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa subunit family.

Copyright

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Cross-references

Sequence databases

EMBL

AE016826; AAO26879.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_777774.1; -.

3D structure databases

ModBase

Q89AU4.

Enzyme and pathway databases

BioCyc

BAPH224915:BBP_145-MON; -.

Ontologies

GO:0009055;	Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0051287;	Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0008137;	Molecular function: NADH dehydrogenase (ubiquinone) activity (inferred from electronic annotation from InterPro).
GO:0048038;	Molecular function: quinone binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006120;	Biological process: mitochondrial electron transport, NADH to ubiquinone (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00329; Complex1_30kDa; 1.
PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

ProDom

PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01961; NuoC_fam; 1.
TIGR01962; NuoD; 1.

PROSITE

PS00542; COMPLEX1_30K; FALSE_NEG.
PS00535; COMPLEX1_49K; 1.

Genome annotation databases

GeneID

1058218; -.

GenomeReviews

AE016826_GR; bbp_145.

KEGG

bab:bbp145; -.

Phylogenomic databases

HOGENOM

Q89AU4; -.

Genome annotation databases

CMR

Q89AU4; bbp_145.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Multifunctional enzyme; NAD; Oxidoreductase; Quinone.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 597`	`597`	`NADH-quinone oxidoreductase subunit C/D.`	`PRO_0000118683`
`REGION`	`1 188`	`188`	`NADH dehydrogenase I subunit C.`
`REGION`	`211 597`	`387`	`NADH dehydrogenase I subunit D.`

Sequence information

Length: 597 AA [This is the length of the unprocessed precursor]

Molecular weight: 69110 Da [This is the MW of the unprocessed precursor]

CRC64: 480D38EFDEE505FA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKEIKRDDV NVIEKDFGNN NSIILKLFKK FGEDSFFIQT TVTDIIVLWI DGSLLLALAK 

        70         80         90        100        110        120 
FLLTINNPYN MLFDLYGIDE RMRLYKHNLP LSHFSVVYHF ISINRNSDII LKIALLEEKL 

       130        140        150        160        170        180 
SLPTLTKLYP NANWYEREIW DMFGISFENH PNLIRILMPK TWVGHPLRKD HPARATEFDP 

       190        200        210        220        230        240 
YVLNKYKEDI EMEALKFKPE EWGMKKNKQS KYMFLNLGPN HPSAHGAFRI ILQLDGEEIV 

       250        260        270        280        290        300 
DCVPDIGYHH RGAEKMGERQ TWHNYIPYTD RVEYLGGCIN EMPYVLAVER LAGIEVSQRI 

       310        320        330        340        350        360 
EVIRIMLSEL FRINSHLLFI STFIQDVGAM TPVFLAFTDR QKIYDLIELI TGSRMHPAWF 

       370        380        390        400        410        420 
RIGGLAHDLP KGWNALLKEF LLWMPKRLLK YINVALKNSI LISRSKGIAE YNKHDALLWG 

       430        440        450        460        470        480 
VTGAGLRATG INFDVRKKRP YSGYQNFDFE VPIGAGISDC YSRVMLKLEE IWQSLAILKQ 

       490        500        510        520        530        540 
CLENMPEGPF KMDHPNTTPP HKVRTLQHIE TMISHFLKVS WGPVLSSNES FKMVEATKGI 

       550        560        570        580        590 
NSYYLISDGN TMSYRTRIRT PSFPHLQQIP SVIRGNLISD LIAYLGSIDF VMSDVDR

Q89AU4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools