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UniProtKB/Swiss-Prot entry Q89AR4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AKH_BUCBP
Primary accession number Q89AR4
Secondary accession numbers None
Integrated into Swiss-Prot on November 14, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 1, 2008 (Entry version 37)
Name and origin of the protein
Protein name Bifunctional aspartokinase/homoserine dehydrogenase
Synonym AK-HD
Includes Aspartokinase
     (EC 2.7.2.4)
Homoserine dehydrogenase
     (EC 1.1.1.3)
Gene name
Name: thrA
OrderedLocusNames: bbp_183
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO26915.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777810.1; -.
3D structure databases
HSSP P31116; 1EBF. [HSSP ENTRY / PDB]
ModBase Q89AR4.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_183-MON; -.
Family and domain databases
InterPro IPR001048; Asp/Glu/Uridylate_kinase.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR001341; Asp_kin_reg.
IPR011147; bifunc_aspartokin/hSer_DHase.
IPR001342; hSer_DHase_cat.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00696; AA_kinase; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000727; ThrA; 1.
TIGRFAMs TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
PS01042; HOMOSER_DHGENASE; 1.
BLOCKS Q89AR4.
Genome annotation databases
GeneID 1058230; -.
GenomeReviews AE016826_GR; bbp_183.
KEGG bab:bbp183; -.
Phylogenomic databases
HOGENOM Q89AR4; -.
Genome annotation databases
CMR Q89AR4; bbp_183.
Other
ProtoNet Q89AR4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Kinase; Multifunctional enzyme; NADP; Oxidoreductase; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   816  816     Bifunctional aspartokinase/homoserine dehydrogenase. PRO_0000066686
NP_BIND   472   479  8     NADP (Potential). 
REGION   1   250  250     Aspartokinase (By similarity). 
REGION   251   471  221     Interface (By similarity). 
REGION   472   816  345     Homoserine dehydrogenase (By similarity). 
Sequence information
Length: 816 AA [This is the length of the unprocessed precursor] Molecular weight: 91919 Da [This is the MW of the unprocessed precursor] CRC64: F8C3ADC0114576B5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKILKFGGTS LSNSELFFHV ATIIENNLNN EQIAIVLSAP GNTTNLLEIA INQTINNKNI 

        70         80         90        100        110        120 
IPIVQKIEKN FLKLINDIYQ VEQKLLYEKI KNNIENKLLE LKNLLQGINL LRQCPDKIRA 

       130        140        150        160        170        180 
KIISSGEYLS ISIMNSILIS RGYNTTIIDP VKKLLTKEDT YLNATVNIKI SKFRILSMKI 

       190        200        210        220        230        240 
PKHHIILMPG FTAGNKQGEL VTLGRNGSDY SATILSVCLN STMCEIWTDV NGVYTCDPKL 

       250        260        270        280        290        300 
VSDAKLLTSL SYREAIELSY LGAKILHPNT IYPIQKFKIP CTIKNTHNPS SIGTKISCNH 

       310        320        330        340        350        360 
VKNKNLITGV TYLENVHMFS ISCLYSKNIE TIIPKIFSCM SLSKIWIILT IQTSSQNTIS 

       370        380        390        400        410        420 
FCILKTMTNT ALHVLHKALY LELKHKLLKP IKVEKKLTLI SVISSDILNN TKITEKVFSI 

       430        440        450        460        470        480 
LKHVNINTLA ISKGASKNSI SIVVKHDDGI LGVRALHKGI FNKNCTAEIF LIGIGRVGQT 

       490        500        510        520        530        540 
FLKQIIEQKN WLKSKNIDLK ICGIANSKNF ILNLDGINPK NWKRDLNLSK KSFNFKHLLN 

       550        560        570        580        590        600 
SIQNYYLINP IIVDCTSDKN IANQYISFIN CGFHIVTPNK KANTTNWKYY EDIRLAAQKE 

       610        620        630        640        650        660 
KKKFFYETNV GAGLPVIENL KNLLRTGDTL IHFKGILSGS LSFIFGKLED NISLSEATKQ 

       670        680        690        700        710        720 
AQSLGFTEPN PKDDLSGIDV ARKLLILARE VGYKLELKDI KIEPLLPKEF NNISNTTDFI 

       730        740        750        760        770        780 
TKLKELDQIF CNRVKKARKL GKRLRFVGII NQKGNCQVKI DEVDHNDPLY NIKNGENALA 

       790        800        810 
FYSKYYQPIP LVLRGYGAGN NVTASGIFSD VLRILL
Q89AR4 in FASTA format

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