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UniProtKB/Swiss-Prot entry Q89AQ1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MURF_BUCBP
Primary accession number Q89AQ1
Secondary accession numbers None
Integrated into Swiss-Prot on April 13, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 43)
Name and origin of the protein
Protein name UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Synonyms EC 6.3.2.10
UDP-MurNAc-pentapeptide synthetase
D-alanyl-D-alanine-adding enzyme
Gene name
Name: murF
OrderedLocusNames: bbp_202
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO26934.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777829.1; -.
3D structure databases
HSSP P11880; 1GG4. [HSSP ENTRY / PDB]
ModBase Q89AQ1.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_202-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0047480; Molecular function: UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity (inferred from electronic annotation from EC).
GO:0008766; Molecular function: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (inferred from electronic annotation from InterPro).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from InterPro).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from InterPro).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004101; Mur_ligase_C.
IPR013221; Mur_ligase_cen.
IPR000713; Mur_ligase_N.
IPR005863; UDP-N-AcMur-3pep_AlaAla_ligase.
Graphical view of domain structure.
Gene3D G3DSA:3.90.190.20; Mur_ligase_C; 1.
G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
PANTHER PTHR23135:SF3; MurF; 1.
Pfam PF01225; Mur_ligase; 1.
PF02875; Mur_ligase_C; 1.
PF08245; Mur_ligase_M; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01143; murF; 1.
BLOCKS Q89AQ1.
ProtoNet Q89AQ1.
Genome annotation databases
GeneID 1058402; -.
GenomeReviews AE016826_GR; bbp_202.
KEGG bab:bbp202; -.
Phylogenomic databases
HOGENOM Q89AQ1; -.
Genome annotation databases
CMR Q89AQ1; bbp_202.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   460  460     UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase. PRO_0000101697
NP_BIND   115   121  7     ATP (Potential). 
Sequence information
Length: 460 AA [This is the length of the unprocessed precursor] Molecular weight: 51092 Da [This is the MW of the unprocessed precursor] CRC64: A0C2DE8052949E2C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MISINLIKLT SITNGILYCS NYATLHSISI HSITTDTRKI TPKCLFIALI GKNFDAHMFV 

        70         80         90        100        110        120 
NEAISKGAAA LLLEKQCYPK NVIPQIIVQN TTIALGKIAS WIRDQTNATV IAITGSSGKT 

       130        140        150        160        170        180 
SVKEMTSSIL KNCGNTISTF QNLNNNIGVP LTLLNLNKSH KYAILELGAN YPKDIEYTTK 

       190        200        210        220        230        240 
ITKPNIALIN NIYHSHLAGF KSLFGVAQAK QEIFLGLRKN GIAIYNKDSN YWSKWKKNLL 

       250        260        270        280        290        300 
TQKIINFSIK KNSTIFASNI TTSNQGSKFK IHSPNGEIYV TLPLLGYHNI SNALAAATIA 

       310        320        330        340        350        360 
ISINIPLEII KIGLSSLPIL KNRLQIIRLN KYKTIINDTY NANTASMIVA IKILENISGY 

       370        380        390        400        410        420 
KLFVAGDMLE LGKNDVLYHK IIGNTIYNSN INEVFSIGKL SKEISIASKK GHHFYNSDEL 

       430        440        450        460 
LKNLKNKLLN KKIITILVKA SRSEKLDVIV EQLIKEYHKA
Q89AQ1 in FASTA format

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