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UniProtKB/Swiss-Prot entry Q89AD8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSH1_BUCBP
Primary accession number Q89AD8
Secondary accession numbers None
Integrated into Swiss-Prot on November 14, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name Glutamate--cysteine ligase
Synonyms EC 6.3.2.2
Gamma-glutamylcysteine synthetase
Gamma-ECS
GCS
Gene name
Name: gshA
OrderedLocusNames: bbp_368
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO27085.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_777980.1; -.
3D structure databases
ModBase Q89AD8.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_368-MON; -.
Ontologies
GO
GO:0004357; Molecular function: glutamate-cysteine ligase activity (inferred from electronic annotation from HAMAP).
GO:0006750; Biological process: glutathione biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00578; -; 1.
PBIL [Tree]
InterPro IPR007370; Glu_cys_ligase.
IPR006334; Glut_cys_ligase.
Graphical view of domain structure.
Pfam PF04262; Glu_cys_ligase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01434; glu_cys_ligase; 1.
BLOCKS Q89AD8.
ProtoNet Q89AD8.
Genome annotation databases
GeneID 1058287; -.
GenomeReviews AE016826_GR; bbp_368.
KEGG bab:bbp368; -.
Phylogenomic databases
HOGENOM Q89AD8; -.
Genome annotation databases
CMR Q89AD8; bbp_368.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glutathione biosynthesis; Ligase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   521  521     Glutamate--cysteine ligase. PRO_0000192522
Sequence information
Length: 521 AA [This is the length of the unprocessed precursor] Molecular weight: 61433 Da [This is the MW of the unprocessed precursor] CRC64: 1FD19D58646C89BB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MIPKIYKKIK WLQSNPLILK KILRGIEREA LRTDIHGTII NTAYPQDKIG SALTHKWITT 

        70         80         90        100        110        120 
DFSESLLEFI TPTNASTNYI LKFLNDTHKF VNDNLIQEYF WPFSIPPCKK YMHSIKLSKY 

       130        140        150        160        170        180 
GTSNLGQVKT LYRKGLKHRY GILMNIISGV HYNFSLPRIF WNHWKKIHHK NTQYNTTSEG 

       190        200        210        220        230        240 
YLCLIRNYYK FGWIIPYLFG ASPAVEPLFI KNKKHNYKFK KHHGMLYLPW STSLRLSDLG 

       250        260        270        280        290        300 
HTNQSIKKLK LTFNSLSEYV LALEHGIKTP SKQFKNLGLY DQFGNFKQIN TNLLQTENEL 

       310        320        330        340        350        360 
YTYIRPKQKL KNCESLSAAL RNRGIEYVEI RALDINPFTS TGVDKNQILL LDLFLIWCVL 

       370        380        390        400        410        420 
ADSPKISSQE FHFFLKNWHT IITKGRKPKQ KININIYNTK NTIQTIGKTI LYDLFYIAEI 

       430        440        450        460        470        480 
LDSLSNNNNY QETCKNLILY FDYPELTYSE KLLNKFMCYG IYETGANLFV KYKQKLHNDS 

       490        500        510        520 
FKILSKKDLN NEMMKSNNSQ KLIEKQDTLN FKEYLNLYYT K
Q89AD8 in FASTA format

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