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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J.,
Kamerbeek J.,
Palacios C.,
Rausell C.,
Abascal F.,
Bastolla U.,
Fernandez J.M.,
Jimenez L.,
Postigo M.,
Silva F.J.,
Tamames J.,
Viguera E.,
Latorre A.,
Valencia A.,
Moran F.,
Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
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- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannitol transport (By similarity).
- CATALYTIC ACTIVITY: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
- CATALYTIC ACTIVITY: Protein EIIB N(pi)-phospho-L-histidine/cysteine + sugar = protein EIIB + sugar phosphate.
- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (Potential).
- DOMAIN: The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
- DOMAIN: The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.
- DOMAIN: The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
- PTM: An intramolecular phosphotransfer takes places between His-556 and Cys-385 (By similarity).
- SIMILARITY: Contains 1 PTS EIIA type-2 domain.
- SIMILARITY: Contains 1 PTS EIIB type-2 domain.
- SIMILARITY: Contains 1 PTS EIIC type-2 domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 640 AA [This is the length of the unprocessed precursor] |
Molecular weight: 70759 Da [This is the MW of the unprocessed precursor] |
CRC64: A5B76D06E6909C3B [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSVPMTVKVQ NLGRFLSAMI MPNISVFIAW GIISGLFIKS GWCPNQTLEK VLSPISVYLF
70 80 90 100 110 120
PILIANTGGY LINGKRGAIV GSIAVVGAII STAIPMLLGA MIIGPIGGWI TYYFDKISKY
130 140 150 160 170 180
KVKSGFEMLV NNFSVGILGV LLLFISFLCI GPMIEKLSCF LGYVVNLMIN NHLLPFIAIL
190 200 210 220 230 240
IEPAKIFFLN NVINHGVLFP LGIQEVVKFN KSIFFLIESN PGPGIGVLMA WFFFGCDNIK
250 260 270 280 290 300
KSLKEAIVIQ LFGGIHEIYF PYVLKNPRLI LALILGSITG IFILIVLRGG LISAASPGSI
310 320 330 340 350 360
ISILAMTPKG LYVINLLAII ISFLVSFLVS CMLLKISNRN HYVKGSNTKI EKDNFLINSS
370 380 390 400 410 420
FQKNRTCIKS SLDSHKCIRN IIFACDAGMG SSAVAAGILR NKIHDLNIFN ITVSNAAIDS
430 440 450 460 470 480
IPNFGVDLII THYSLTDRAR KRNSNAKHLS LNSFLDNAFY NELSKYLVEN NLDNNSSILD
490 500 510 520 530 540
FSVRNQNNFS SKKNVFSLTK ENIFLGQIAS SKEEVIRFIG RQLVNQGYVK EEYIEAMLER
550 560 570 580 590 600
EKMMSTWLGE SIALPHGTIQ SKDFILNTGI IFCQFPNGIL FGDDPEDIAH LVIGVAARNN
610 620 630 640
EHIPVVSNIT NILDNNDVIK SLSITKNIDD VLYLFSRKNI
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Q89A36 in FASTA format |
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