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UniProtKB/Swiss-Prot entry Q89A20

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC_BUCBP
Primary accession number Q89A20
Secondary accession numbers None
Integrated into Swiss-Prot on November 14, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 38)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene name
Name: ilvC
OrderedLocusNames: bbp_541
From
Buchnera aphidicola subsp. Baizongia pistaciae [TaxID: 135842] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0235981100; PubMed=12522265 [NCBI, ExPASy, EBI, Israel, Japan]
van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F., Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J., Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
"Reductive genome evolution in Buchnera aphidicola.";
Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016826; AAO27240.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_778135.1; -.
3D structure databases
HSSP Q9HVA2; 1NP3. [HSSP ENTRY / PDB]
ModBase Q89A20.
Enzyme and pathway databases
BioCyc BAPH224915:BBP_541-MON; -.
Ontologies
GO
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR014359; KetolA_reductoisomerase_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000116; IlvC_gammaproteo; 1.
TIGRFAMs TIGR00465; ilvC; 1.
BLOCKS Q89A20.
Genome annotation databases
GeneID 1058333; -.
GenomeReviews AE016826_GR; bbp_541.
KEGG bab:bbp541; -.
Phylogenomic databases
HOGENOM Q89A20; -.
Genome annotation databases
CMR Q89A20; bbp_541.
Other
ProtoNet Q89A20.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   491  491     Ketol-acid reductoisomerase. PRO_0000151288
ACT_SITE   133   133        Potential. 
Sequence information
Length: 491 AA [This is the length of the unprocessed precursor] Molecular weight: 55968 Da [This is the MW of the unprocessed precursor] CRC64: 9583C462A6D0EA82 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGSNYFNSLN FRQKLIQLRQ CTLIRKEEFS ETFKILKGKN IVIVGCGSQG LNQGLNMRDS 

        70         80         90        100        110        120 
GLNVKYALRK NSIISQRSSW KRAIDNKFLV GTCEELIPTA DLVINLTPDK QHEHVVDVLQ 

       130        140        150        160        170        180 
NLMKKNSILG FSHGFNIIEF GQKIRQDITV IMVAPKCPGT EVREEYKRNF GVPTLISVHL 

       190        200        210        220        230        240 
DNDCHNIGLE VAKEWATAIG GHRAGVLHSS FSAEVKSDLM GEQTILCGLL QTGSVLCYDK 

       250        260        270        280        290        300 
LISQGHDCHY AVKLVQSGWE VITESLKHGG ITLMFDRLSN TAKIRAYKLS NDLKKILSPI 

       310        320        330        340        350        360 
FKKHMDDILS GYYSKNMMLD WKNDDKQLKI WRRSIQNTSF EQCSISHITL LEHEYFENGL 

       370        380        390        400        410        420 
LMVAIIRAGV ELAFEIMIEA GIKEESAYYE SLHELPLIAN TIARKRLYEM NLIISDTAEY 

       430        440        450        460        470        480 
GSHLFFQSAF PLLQDFMNTL EHGDLGNKML DQAINNVDLN YINTTIRNHP VEHIGQKLRR 

       490 
YMTNIKQINC Y
Q89A20 in FASTA format

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