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UniProtKB/Swiss-Prot entry Q897P8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDLA_CLOTE
Primary accession number Q897P8
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 40)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase A
Synonyms EC 6.3.2.4
D-alanylalanine synthetase A
D-Ala-D-Ala ligase A
Gene name
Name: ddlA
OrderedLocusNames: CTC_00683
From
Clostridium tetani [TaxID: 1513] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Massachusetts / E88;
DOI=10.1073/pnas.0335853100; PubMed=12552129 [NCBI, ExPASy, EBI, Israel, Japan]
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.;
"The genome sequence of Clostridium tetani, the causative agent of tetanus disease.";
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015927; AAO35288.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_781351.1; -.
3D structure databases
HSSP P07862; 1IOW. [HSSP ENTRY / PDB]
ModBase Q897P8.
Enzyme and pathway databases
BioCyc CTET212717:CTC_00683-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q897P8.
Genome annotation databases
GeneID 1058953; -.
GenomeReviews AE015927_GR; CTC_00683.
KEGG ctc:CTC00683; -.
NMPDR fig|212717.1.peg.573; -.
Phylogenomic databases
HOGENOM Q897P8; -.
Genome annotation databases
CMR Q897P8; CTC_00683.
Other
ProtoNet Q897P8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   301  301     D-alanine--D-alanine ligase A. PRO_0000177809
DOMAIN   99   293  195     ATP-grasp. 
NP_BIND   126   181  56     ATP (By similarity). 
METAL   248   248        Magnesium or manganese 1 (By similarity). 
METAL   260   260        Magnesium or manganese 1 (By similarity). 
METAL   260   260        Magnesium or manganese 2 (By similarity). 
METAL   262   262        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 301 AA [This is the length of the unprocessed precursor] Molecular weight: 34031 Da [This is the MW of the unprocessed precursor] CRC64: AEC30BCA0618FDF5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQIGVVMGGV STEKEISNLT GKYIIENLDK SKYEILPIPI NTKFELIDKI KCLEFAFIAL 

        70         80         90        100        110        120 
HGNFGEDGKV QALLETMGVP YSGSGVLASS LCMDKNMSKK ILQGEGIKTP RWIMLYKNED 

       130        140        150        160        170        180 
IDFESIKNIG YPLVVKPNSG GSSIGITIVK KEQELIKAIE EAFKFDEEIL IEEYIKGEEI 

       190        200        210        220        230        240 
TCCMLDGKPL PILSIKTKEE FFNYKAKYFE GVAEEKVADL SLELKDQVEK ISNKCWKSFK 

       250        260        270        280        290        300 
LKVYGRIDMI IKGNEVYVIE INTLPGMTKY SLFPKSAKAY GLNFSELLDK IIELSIKEYE 


F
Q897P8 in FASTA format

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