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UniProtKB/Swiss-Prot entry Q893Q9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name THIM_CLOTE
Primary accession number Q893Q9
Secondary accession numbers None
Integrated into Swiss-Prot on May 24, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 41)
Name and origin of the protein
Protein name Hydroxyethylthiazole kinase
Synonyms EC 2.7.1.50
4-methyl-5-beta-hydroxyethylthiazole kinase
Thz kinase
TH kinase
Gene name
Name: thiM
OrderedLocusNames: CTC_01752
From
Clostridium tetani [TaxID: 1513] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Massachusetts / E88;
DOI=10.1073/pnas.0335853100; PubMed=12552129 [NCBI, ExPASy, EBI, Israel, Japan]
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.;
"The genome sequence of Clostridium tetani, the causative agent of tetanus disease.";
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015927; AAO36283.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_782346.1; -.
3D structure databases
ModBase Q893Q9.
Enzyme and pathway databases
BioCyc CTET212717:CTC_01752-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004417; Molecular function: hydroxyethylthiazole kinase activity (inferred from electronic annotation from HAMAP).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009228; Biological process: thiamin biosynthetic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00228; -; 1.
PBIL [Tree]
InterPro IPR000417; Hyethyz_kinase.
IPR011144; Hyethyz_kinsmonf.
Graphical view of domain structure.
PANTHER PTHR20857:SF14; Hyethyz_kinase; 1.
Pfam PF02110; HK; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000513; Thz_kinase; 1.
PRINTS PR01099; HYETHTZKNASE.
TIGRFAMs TIGR00694; thiM; 1.
BLOCKS Q893Q9.
ProtoNet Q893Q9.
Genome annotation databases
GeneID 1060928; -.
GenomeReviews AE015927_GR; CTC_01752.
KEGG ctc:CTC01752; -.
NMPDR fig|212717.1.peg.1568; -.
Phylogenomic databases
HOGENOM Q893Q9; -.
Genome annotation databases
CMR Q893Q9; CTC_01752.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Thiamine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   274  274     Hydroxyethylthiazole kinase. PRO_0000156930
METAL   95    95        Magnesium 1 (By similarity). 
METAL   127   127        Magnesium 1 (By similarity). 
BINDING   46    46        Substrate; via amide nitrogen (By similarity). 
BINDING   122   122        ATP (By similarity). 
BINDING   173   173        ATP (By similarity). 
BINDING   200   200        Substrate; via amide nitrogen (By similarity). 
Sequence information
Length: 274 AA [This is the length of the unprocessed precursor] Molecular weight: 29748 Da [This is the MW of the unprocessed precursor] CRC64: 8C2291B24B27814B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEIYKKIYNS LLKLKEKNPL IHHITNYVTV NDCANIVLAI GASPVMADDI REVEDMVSIA 

        70         80         90        100        110        120 
SALVINIGTL NKKTVKSMFL AGKKANELNI PVILDPVGVG ATKYRTSIAL ELLEEIKFSV 

       130        140        150        160        170        180 
VRGNISEVKV LSGMNASTKG VDAESWDETN PIEERIRLVK SLSEKYNAVI GITGEKDVIG 

       190        200        210        220        230        240 
FKEEVYTVEN GSSIMAKITG AGCMCTSVIA SYCGAEENYL QATLSGVVSM GIAGEIAYEK 

       250        260        270 
TKNLGPSSFR TALIDSIYNL EESSFNERGK VYNA
Q893Q9 in FASTA format

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