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UniProtKB/Swiss-Prot entry Q891L4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KHSE_CLOTE
Primary accession number Q891L4
Secondary accession numbers None
Integrated into Swiss-Prot on February 15, 2005
Sequence was last modified on February 15, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 37)
Name and origin of the protein
Protein name Homoserine kinase
Synonyms HSK
HK
EC 2.7.1.39
Gene name
Name: thrB
OrderedLocusNames: CTC_02357
From
Clostridium tetani [TaxID: 1513] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae; Clostridium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Massachusetts / E88;
DOI=10.1073/pnas.0335853100; PubMed=12552129 [NCBI, ExPASy, EBI, Israel, Japan]
Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.;
"The genome sequence of Clostridium tetani, the causative agent of tetanus disease.";
Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015927; AAO36831.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_782894.1; -.
3D structure databases
HSSP Q58504; 1H74. [HSSP ENTRY / PDB]
ModBase Q891L4.
Enzyme and pathway databases
BioCyc CTET212717:CTC_02357-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004413; Molecular function: homoserine kinase activity (inferred from electronic annotation from HAMAP).
GO:0016310; Biological process: phosphorylation (inferred from electronic annotation from InterPro).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00384; -; 1.
PBIL [Tree]
InterPro IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR000870; Homoser_kin.
IPR014721; Ribosomal_S5_D2-type_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
Pfam PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000676; Homoser_kin; 1.
PRINTS PR00958; HOMSERKINASE.
TIGRFAMs TIGR00191; thrB; 1.
PROSITE PS00627; GHMP_KINASES_ATP; 1.
BLOCKS Q891L4.
ProtoNet Q891L4.
Genome annotation databases
GeneID 1060525; -.
GenomeReviews AE015927_GR; CTC_02357.
KEGG ctc:CTC02357; -.
NMPDR fig|212717.1.peg.2116; -.
Phylogenomic databases
HOGENOM Q891L4; -.
Genome annotation databases
CMR Q891L4; CTC_02357.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   300  300     Homoserine kinase. PRO_0000156562
NP_BIND   82    92  11     ATP (Potential). 
Sequence information
Length: 300 AA [This is the length of the unprocessed precursor] Molecular weight: 33472 Da [This is the MW of the unprocessed precursor] CRC64: E9D0386477A9C257 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLEIKVPGTS ANFGPGFDSL GVALSIYNKF YVEEIESGIY IEGCEEKYRN DKNLFYVSMK 

        70         80         90        100        110        120 
KVFDKFGYKL KGLRIKIEGD IPESRGLGSS ASCIVGGVMA ANDFIGNKLS KEEMLEISTE 

       130        140        150        160        170        180 
IEGHPDNVAP AIFGGMTAVV KDKDRIYHDK IDIDKNINFH ALIPNFILST KKSREVLPKT 

       190        200        210        220        230        240 
VDYKDAVFNV GRVALMISSL ISGKYENLEV AFEDKLHQPY RKELIGNYDD LIVKCKKNGA 

       250        260        270        280        290        300 
LGVFLSGAGP TIMAITEKHR EDFLKNMNEE LRILNHKWNI KKLVVDHKGA TVISKLNGGI
Q891L4 in FASTA format

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