ID   MTLD_LACPL              Reviewed;         385 AA.
AC   Q88ZS1;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-NOV-2008, entry version 28.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=lp_0233;
OS   Lactobacillus plantarum.
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   MEDLINE=22480296; PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA   Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA   Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA   Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA   De Vos W.M., Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; AL935252; CAD62894.1; -; Genomic_DNA.
DR   RefSeq; NP_784055.1; -.
DR   GeneID; 1061392; -.
DR   GenomeReviews; AL935263_GR; lp_0233.
DR   KEGG; lpl:lp_0233; -.
DR   NMPDR; fig|220668.1.peg.189; -.
DR   HOGENOM; Q88ZS1; -.
DR   BioCyc; LPLA220668:LP_0233-MON; -.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DHase_multihelical.
DR   InterPro; IPR013118; Mannitol_DHase_C.
DR   InterPro; IPR000669; Mannitol_DHase_core.
DR   InterPro; IPR013131; Mannitol_DHase_N.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    385       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_0000170709.
FT   NP_BIND       3     14       NAD (By similarity).
SQ   SEQUENCE   385 AA;  43200 MW;  1B174ECC6B5D2C8B CRC64;
     MLDVHFGAGN IGRGFIGETL ADNGFKITFV DVNDTLIDEL NKRNGYTIEL AAEGQKHIEV
     HDVKGINNGK DPKAVAEEIA QADMVTTAIG PKILKFIAPL IADGLKLRQA NNNTTPIDII
     ACENMIGGSQ SLKKSVYESL NEDEQAWADQ NAGFPNAAVD RIVPLQKHDD PLFVSVEPFK
     EWVIDKSQMK NPKIQLKGVD YADDLEPYIE RKLFSVNTGH ATVAYTGNMK GYKTIGEAVK
     DDSVVDQAKH VLGETGDLLI QKWGFDPEVH HAYQKKILSR FENPYISDDI ERVGRTPIRK
     LGFNERFIRP IRELKERGRD YSALVDTVGE MFFFNYPNDS ESVKLQQLLK DEPIEQVIRE
     TTDLKDEDLV NEIKAAYEKH LAAAK
//