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UniProtKB/Swiss-Prot entry Q88Z14

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NADE_LACPL
Primary accession number Q88Z14
Secondary accession numbers None
Integrated into Swiss-Prot on May 20, 2008
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 34)
Name and origin of the protein
Protein name NH(3)-dependent NAD(+) synthetase
Synonym EC 6.3.1.5
Gene name
Name: nadE
OrderedLocusNames: lp_0566
From
Lactobacillus plantarum [TaxID: 1590] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
DOI=10.1073/pnas.0337704100; PubMed=12566566 [NCBI, ExPASy, EBI, Israel, Japan]
Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M., Siezen R.J.;
"Complete genome sequence of Lactobacillus plantarum WCFS1.";
Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AL935253; CAD63181.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_784340.1; -.
3D structure databases
HSSP P08164; 1IH8. [HSSP ENTRY / PDB]
ModBase Q88Z14.
Enzyme and pathway databases
BioCyc LPLA220668:LP_0566-MON; -.
Ontologies
GO
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003952; Molecular function: NAD+ synthase (glutamine-hydrolyzing) activity (inferred from electronic annotation from InterPro).
GO:0008795; Molecular function: NAD+ synthase activity (inferred from electronic annotation from EC).
GO:0009435; Biological process: NAD biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00193; -; 1.
PBIL [Tree]
InterPro IPR003694; NAD_synthase.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
Pfam PF02540; NAD_synthase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00552; nadE; 1.
BLOCKS Q88Z14.
ProtoNet Q88Z14.
Genome annotation databases
GeneID 1064235; -.
GenomeReviews AL935263_GR; lp_0566.
KEGG lpl:lp_0566; -.
NMPDR fig|220668.1.peg.474; -.
Phylogenomic databases
HOGENOM Q88Z14; -.
Genome annotation databases
CMR Q88Z14; lp_0566.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Ligase; NAD; Nucleotide-binding.
Features
SEVIEWER logo Feature table viewer
KeyFrom  To Length Description FTId
CHAIN   1   275  275     NH(3)-dependent NAD(+) synthetase. PRO_1000077568
NP_BIND   47    54  8     ATP (By similarity). 
ACT_SITE   49    49        By similarity. 
Sequence information
Length: 275 AA [This is the length of the unprocessed precursor] Molecular weight: 30590 Da [This is the MW of the unprocessed precursor] CRC64: A1C78763ED7949D5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRPLQAEIIK ALHVAPTIDP EVEIRRSIDF LKAYLTKNTF LKTYVLGISG GQDSTLAGKL 

        70         80         90        100        110        120 
TEMAITEMRQ ETGDDRYQFI AVRLPYGNQA DEADAMAAID FMQADVTDRV DIQPATDAMV 

       130        140        150        160        170        180 
TALEANQLTI HDFNKGNIKA RQRMIVQYGI AGEMHGAVVG TDHAAEAVTG FYTKYGDGGA 

       190        200        210        220        230        240 
DIVPLWRLNK RQGKQMLAAL DAPKHLYDKV PTADLEEDRP ALPDEVALGV RYDDIDDYLE 

       250        260        270 
GRTVSDAAAE KIEAWYLKTA HKRHAAITVF DDFWK
Q88Z14 in FASTA format

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