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UniProtKB/Swiss-Prot entry Q88R90

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GSH1_PSEPK
Primary accession number Q88R90
Secondary accession numbers None
Integrated into Swiss-Prot on March 1, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 32)
Name and origin of the protein
Protein name Glutamate--cysteine ligase
Synonyms EC 6.3.2.2
Gamma-glutamylcysteine synthetase
Gamma-ECS
GCS
Gene name
Name: gshA
OrderedLocusNames: PP_0243
From
Pseudomonas putida (strain KT2440) [TaxID: 160488] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1462-2920.2002.00366.x; PubMed=12534463 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.";
Environ. Microbiol. 4:799-808(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015451; AAN65875.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_742411.1; -.
3D structure databases
ModBase Q88R90.
Enzyme and pathway databases
BioCyc PPUT160488:PP_0243-MON; -.
Ontologies
GO
GO:0004357; Molecular function: glutamate-cysteine ligase activity (inferred from electronic annotation from HAMAP).
GO:0006750; Biological process: glutathione biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00578; -; 1.
PBIL [Tree]
InterPro IPR007370; Glu_cys_ligase.
IPR006334; Glut_cys_ligase.
Graphical view of domain structure.
Pfam PF04262; Glu_cys_ligase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01434; glu_cys_ligase; 1.
BLOCKS Q88R90.
ProtoNet Q88R90.
Genome annotation databases
GeneID 1043812; -.
GenomeReviews AE015451_GR; PP_0243.
KEGG ppu:PP_0243; -.
NMPDR fig|160488.1.peg.241; -.
TIGR PP_0243; -.
Phylogenomic databases
HOGENOM Q88R90; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glutathione biosynthesis; Ligase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   525  525     Glutamate--cysteine ligase. PRO_0000192533
Sequence information
Length: 525 AA [This is the length of the unprocessed precursor] Molecular weight: 59068 Da [This is the MW of the unprocessed precursor] CRC64: F868F5EC025D580B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSELLNRRLS LLGANLPLLK QCLHGIEREC LRVTDEGRLA QTPHPEALGS ALTNEQITTD 

        70         80         90        100        110        120 
YSESLLEFIT PALADPAKVL ESLEETHRFV YSKLGDEYLW SPSMPCTLPA EEDIPIAEYG 

       130        140        150        160        170        180 
SSNIGKLKHV YRKGLALRYG RTMQCIAGIH YNFSLPEALW PLLREAEGST ENDRDYQSSA 

       190        200        210        220        230        240 
YIALIRNFRR YSWLLMYLFG ASPALDKGFL RGRPHQLEEL DAETLFLPYA TSLRMSDLGY 

       250        260        270        280        290        300 
QSNAQAGLTP CYNNLASYTD SLRKAVGTPY PPYVEIGTHV DGEWVQLNTN ILQIENEYYS 

       310        320        330        340        350        360 
NIRPKRVTYT GERPIQALTS RGVQYVEVRC LDINPFLPVG IDLTEARFLD AFLLFCALED 

       370        380        390        400        410        420 
SPQLDNGECG QCTSNFLTVV KEGRRPGLEL HRNGQPISLK DWASELIGRI RQLANLLDQA 

       430        440        450        460        470        480 
QGSDEHAKAL DAQQAKVDDT SLTPSAQVLA RMTEHDESFV QFSLRQSRVH AETFREQPLS 

       490        500        510        520 
NEKQQAFETL ARESLARQSE LEQNEVGDFD LFVGAYQASI LAISS
Q88R90 in FASTA format

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