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UniProtKB/Swiss-Prot entry Q88LQ9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TPMT_PSEPK
Primary accession number Q88LQ9
Secondary accession numbers None
Integrated into Swiss-Prot on September 13, 2005
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 32)
Name and origin of the protein
Protein name Thiopurine S-methyltransferase
Synonyms EC 2.1.1.67
Thiopurine methyltransferase
Gene name
Name: tpm
OrderedLocusNames: PP_1870
From
Pseudomonas putida (strain KT2440) [TaxID: 160488] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1462-2920.2002.00366.x; PubMed=12534463 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.";
Environ. Microbiol. 4:799-808(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015451; AAN67489.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_744025.1; -.
3D structure databases
HSSP O86262; 1PJZ. [HSSP ENTRY / PDB]
ModBase Q88LQ9.
Enzyme and pathway databases
BioCyc PPUT160488:PP_1870-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008119; Molecular function: thiopurine S-methyltransferase activity (inferred from electronic annotation from HAMAP).
GO:0008152; Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00812; -; 1.
PBIL [Tree]
InterPro IPR008854; Thiopurine_S-MeTrfase.
IPR016822; Thiopurine_S-MeTrfase_sub.
Graphical view of domain structure.
Pfam PF05724; TPMT; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF023956; Thiopurine_S-methyltransferase; 1.
BLOCKS Q88LQ9.
ProtoNet Q88LQ9.
Genome annotation databases
GeneID 1043226; -.
GenomeReviews AE015451_GR; PP_1870.
KEGG ppu:PP_1870; -.
NMPDR fig|160488.1.peg.1855; -.
TIGR PP_1870; -.
Phylogenomic databases
HOGENOM Q88LQ9; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Methyltransferase; S-adenosyl-L-methionine; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   216  216     Thiopurine S-methyltransferase. PRO_0000220128
BINDING   10    10        S-adenosyl-L-methionine (By similarity). 
BINDING   45    45        S-adenosyl-L-methionine; via carbonyl oxygen (By similarity). 
BINDING   66    66        S-adenosyl-L-methionine (By similarity). 
BINDING   123   123        S-adenosyl-L-methionine (By similarity). 
Sequence information
Length: 216 AA [This is the length of the unprocessed precursor] Molecular weight: 24365 Da [This is the MW of the unprocessed precursor] CRC64: BACCB654D25D1BEC [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEPAFWQQRW ADNQIGFHQA QVNPYLQTYW PQLQLAPGSR VLVPLCGKSL DLAWLAGQGH 

        70         80         90        100        110        120 
RVLGVELSRR AVEDFFREHG LEAEVRQQGA FEVWRSGDVQ LWCGDFFALR AEDVADCVGL 

       130        140        150        160        170        180 
YDRAAVIALP VQMRARYMQL LSGLLPANCR GLVVTLEYDQ SLLAGPPFSV RDEELRQGFA 

       190        200        210 
GWQVEQLEAV DVIEDSPKFV QAGASSLLER VYQVSR
Q88LQ9 in FASTA format

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