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UniProtKB/Swiss-Prot entry Q88EV6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DDLA_PSEPK
Primary accession number Q88EV6
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 2003
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 39)
Name and origin of the protein
Protein name D-alanine--D-alanine ligase A
Synonyms EC 6.3.2.4
D-alanylalanine synthetase A
D-Ala-D-Ala ligase A
Gene name
Name: ddlA
OrderedLocusNames: PP_4346
From
Pseudomonas putida (strain KT2440) [TaxID: 160488] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1046/j.1462-2920.2002.00366.x; PubMed=12534463 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H., Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M., Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F., Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I., Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A., Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H., Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C., Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
"Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440.";
Environ. Microbiol. 4:799-808(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE015451; AAN69925.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_746461.1; -.
3D structure databases
HSSP P07862; 1IOW. [HSSP ENTRY / PDB]
ModBase Q88EV6.
Enzyme and pathway databases
BioCyc PPUT160488:PP_4346-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0008716; Molecular function: D-alanine-D-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00047; -; 1.
PBIL [Tree]
InterPro IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR000291; D-Ala_lig_Van_CS.
IPR005905; D_ala_D_ala.
IPR011095; Dala_Dala_lig_C.
IPR011127; Dala_Dala_lig_N.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
Pfam PF07478; Dala_Dala_lig_C; 1.
PF01820; Dala_Dala_lig_N; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01205; D_ala_D_alaTIGR; 1.
PROSITE PS50975; ATP_GRASP; 1.
PS00843; DALA_DALA_LIGASE_1; 1.
PS00844; DALA_DALA_LIGASE_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q88EV6.
Genome annotation databases
GeneID 1042642; -.
GenomeReviews AE015451_GR; PP_4346.
KEGG ppu:PP_4346; -.
NMPDR fig|160488.1.peg.4291; -.
TIGR PP_4346; -.
Phylogenomic databases
HOGENOM Q88EV6; -.
Other
ProtoNet Q88EV6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   352  352     D-alanine--D-alanine ligase A. PRO_0000177857
DOMAIN   138   341  204     ATP-grasp. 
NP_BIND   165   220  56     ATP (By similarity). 
METAL   295   295        Magnesium or manganese 1 (By similarity). 
METAL   308   308        Magnesium or manganese 1 (By similarity). 
METAL   308   308        Magnesium or manganese 2 (By similarity). 
METAL   310   310        Magnesium or manganese 2 (By similarity). 
Sequence information
Length: 352 AA [This is the length of the unprocessed precursor] Molecular weight: 37805 Da [This is the MW of the unprocessed precursor] CRC64: 51FA8522FD896BB1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKQNVIALVF GGRSSEHSVA LRSAATIHAA LMALGHRVHC VGIDREGNWR YQGEPCQFPG 

        70         80         90        100        110        120 
AVDRSAPLIS IRPGHRSLSY TTQESGTVEI GIDLLFPALH GRWGEDGTIQ GLAAMCGLPC 

       130        140        150        160        170        180 
VGSGVLGSAM AMDKDVTKRM VQSAGLVVVP WLAMNSMRPW EELVECLGSS TLFVKPATSG 

       190        200        210        220        230        240 
SSIGVSRVSN ALEYAAAFAI AAREDTKVLV EAAVCGREIE CGVLELEEGL MASVVGEIIK 

       250        260        270        280        290        300 
KEGHAYYDYQ AKYDSNSVTG LRVPSLLPPD IVARIQALSV QAFRCLELKG YARVDFFLTE 

       310        320        330        340        350 
EGEIILNEIN TLPGFTSASM YPKMFECSGY PPPKLVGALV EYGLSSASKE RL
Q88EV6 in FASTA format

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