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UniProtKB/Swiss-Prot entry Q87Q92

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_VIBPA
Primary accession number Q87Q92
Secondary accession numbers None
Integrated into Swiss-Prot on December 6, 2005
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 34)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: VP1258
From
Vibrio parahaemolyticus [TaxID: 670] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=RIMD 2210633 / Serotype O3:K6;
DOI=10.1016/S0140-6736(03)12659-1; PubMed=12620739 [NCBI, ExPASy, EBI, Israel, Japan]
Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K., Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S., Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
"Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism distinct from that of V. cholerae.";
Lancet 361:743-749(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BA000031; BAC59521.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_797637.1; -.
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase Q87Q92.
Enzyme and pathway databases
BioCyc VPAR223926:VP1258-MON; -.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS Q87Q92.
Genome annotation databases
GeneID 1188763; -.
GenomeReviews BA000031_GR; VP1258.
KEGG vpa:VP1258; -.
NMPDR fig|223926.1.peg.1258; -.
Phylogenomic databases
HOGENOM Q87Q92; -.
Genome annotation databases
CMR Q87Q92; VP1258.
Other
ProtoNet Q87Q92.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   562  562     NAD-dependent malic enzyme. PRO_0000160236
ACT_SITE   101   101        Proton donor (By similarity). 
ACT_SITE   172   172        Proton acceptor (By similarity). 
METAL   243   243        Divalent metal cation (By similarity). 
METAL   244   244        Divalent metal cation (By similarity). 
METAL   267   267        Divalent metal cation (By similarity). 
BINDING   154   154        NAD (By similarity). 
BINDING   267   267        NAD (By similarity). 
BINDING   415   415        NAD (By similarity). 
SITE   267   267  1     Important for activity (By similarity). 
Sequence information
Length: 562 AA [This is the length of the unprocessed precursor] Molecular weight: 62299 Da [This is the MW of the unprocessed precursor] CRC64: E1B8D7A80CF073F3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNNDKRPLYI PYAGPALMAT PLLNKGSAFS AEERSSFNLE GLLPETTETI QEQVERAYQQ 

        70         80         90        100        110        120 
YKSFESDMDK HIYLRNIQDT NETLFYRLVQ NHISEMMPII YTPTVGAACE NFSNIYRRGR 

       130        140        150        160        170        180 
GLFISYPNRD RIDDLLNNAA NHNVKVIVVT DGERILGLGD QGIGGMGIPI GKLSLYTACG 

       190        200        210        220        230        240 
GISPAYTLPI VLDVGTNNPQ RLADPMYMGW RHPRITGPDY DAFVEEFIQA VQRRWPDALI 

       250        260        270        280        290        300 
QFEDFAQKNA MPLLERYKDR ICCFNDDIQG TAAVTVGSLL AACKAAGTQL SKQRITFLGA 

       310        320        330        340        350        360 
GSAGCGIAEA IIAQMVSEGI SDEKARSQVY MVDRWGLLQE GMPNLLDFQQ RLVQKHSNTK 

       370        380        390        400        410        420 
EWENEGNGFS LLDVMRNAKP TVLIGVSGAP GLFSQEVIEE MHKHCKRPIV FPLSNPTSRV 

       430        440        450        460        470        480 
EATPNDIIRW TNGEALVATG SPFDPVVHEG RTYPIAQCNN SYIFPGIGLG VLAVNAKRVT 

       490        500        510        520        530        540 
DEMLMESSRA LATCSPLAIN GRGALLPPLE EIHLVSKKIA FAVAKKAIEQ GVALEITDEA 

       550        560 
LNDAIDQAFW QPVYRRYKRT AF
Q87Q92 in FASTA format

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