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UniProtKB/Swiss-Prot entry Q86W92


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LIPB1_HUMAN
Primary accession number Q86W92
Secondary accession numbers O75336 Q86X70 Q9NY03 Q9ULJ0
Integrated into Swiss-Prot on February 16, 2004
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 64)
Name and origin of the protein
Protein name Liprin-beta-1
Synonyms Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1
PTPRF-interacting protein-binding protein 1
hSGT2
Gene name
Name: PPFIBP1
Synonyms: KIAA1230
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), VARIANT LEU-148, TISSUE SPECIFICITY, AND FUNCTION.
DOI=10.1074/jbc.273.25.15611; PubMed=9624153 [NCBI, ExPASy, EBI, Israel, Japan]
Serra-Pages C., Medley Q.G., Tang M., Hart A., Streuli M.;
"Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.";
J. Biol. Chem. 273:15611-15620(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT LEU-148.
TISSUE=Brain;
DOI=10.1093/dnares/6.5.337; PubMed=10574462 [NCBI, ExPASy, EBI, Israel, Japan]
Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.";
DNA Res. 6:337-345(1999).
[3]
SEQUENCE REVISION.
DOI=10.1093/dnares/9.3.99; PubMed=12168954 [NCBI, ExPASy, EBI, Israel, Japan]
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.";
DNA Res. 9:99-106(2002).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), AND VARIANT LEU-148.
Junjian L., Cheng J., Rouli Z., Jie Z.;
"L2, a different isoform of Liprin beta 1, is expressed in high level in liver tissue.";
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), AND VARIANT LEU-148.
TISSUE=Brain;
Sato T., Jigami Y., Uemura H.;
"hSGT2, a liprin related human gene, restores the glycolytic gene expression of the gcr2 mutant of Saccharomyces cerevisiae.";
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANT LEU-148.
TISSUE=Brain, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
INTERACTION WITH S100A4.
DOI=10.1074/jbc.M110976200; PubMed=11836260 [NCBI, ExPASy, EBI, Israel, Japan]
Kriajevska M., Fischer-Larsen M., Moertz E., Vorm O., Tulchinsky E., Grigorian M., Ambartsumian N., Lukanidin E.;
"Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).";
J. Biol. Chem. 277:5229-5235(2002).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-999 AND SER-1003, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37; THR-39; SER-40; SER-466; SER-540; SER-579; SER-601; SER-999; SER-1001; SER-1003; THR-1005 AND SER-1009, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF034802; AAC26103.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB033056; BAA86544.2; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ276680; CAB77544.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB049149; BAB39690.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC046159; AAH46159.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC050281; AAH50281.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00179172; -.
IPI00302158; -.
IPI00397366; -.
IPI00397367; -.
IPI00397368; -.
RefSeq NP_003613.2; -.
NP_803193.1; -.
UniGene Hs.172445
3D structure databases
HSSP P28693; 1SGG. [HSSP ENTRY / PDB]
ModBase Q86W92.
Protein-protein interaction databases
IntAct Q86W92; 3.
PTM databases
PhosphoSite Q86W92; -.
Organism-specific databases
GeneCards GC12P027568; -.
H-InvDB HIX0010507; -.
HGNC HGNC:9249; PPFIBP1.
GenAtlas PPFIBP1.
HPA HPA001924; -.
MIM 603141; gene. [NCBI / EBI]
PharmGKB PA33570; -.
HUGE KIAA1230.
Gene expression databases
ArrayExpress Q86W92; -.
Bgee Q86W92; -.
CleanEx HS_PPFIBP1; -.
GermOnline ENSG00000110841; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from HPA).
GO:0005886; Cellular component: plasma membrane (inferred from direct assay from HPA).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007155; Biological process: cell adhesion (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR001660; SAM.
IPR011510; SAM_2.
IPR013761; SAM_type.
Graphical view of domain structure.
Gene3D G3DSA:1.10.150.50; SAM_type; 1.
Pfam PF00536; SAM_1; 2.
PF07647; SAM_2; 1.
Pfam graphical view of domain structure.
SMART SM00454; SAM; 3.
SMART graphical view of domain structure.
PROSITE PS50105; SAM_DOMAIN; 2.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE Q86W92; -.
Genome annotation databases
Ensembl ENSG00000110841; Homo sapiens. [Contig view]
GeneID 8496; -.
KEGG hsa:8496; -.
NMPDR fig|9606.3.peg.7335; -.
Phylogenomic databases
HOGENOM Q86W92; -.
HOVERGEN Q86W92; -.
OMA Q86W92; KPETSFE.
Other
NextBio 31783; -.
SOURCE PPFIBP1; Homo sapiens.
ProtoNet Q86W92.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Coiled coil; Phosphoprotein; Polymorphism; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1011  1011     Liprin-beta-1. PRO_0000191034
DOMAIN   647    711  65     SAM 1. 
DOMAIN   719    782  64     SAM 2. 
DOMAIN   804    876  73     SAM 3. 
COILED   156    405  250     Potential. 
MOD_RES   37     37        Phosphoserine. 
MOD_RES   39     39        Phosphothreonine. 
MOD_RES   40     40        Phosphoserine. 
MOD_RES   466    466        Phosphoserine. 
MOD_RES   540    540        Phosphoserine. 
MOD_RES   579    579        Phosphoserine. 
MOD_RES   601    601        Phosphoserine. 
MOD_RES   999    999        Phosphoserine. 
MOD_RES   1001   1001        Phosphoserine. 
MOD_RES   1003   1003        Phosphoserine. 
MOD_RES   1005   1005        Phosphothreonine. 
MOD_RES   1009   1009        Phosphoserine. 
VAR_SEQ   1    153        Missing (in isoform 3). VSP_009394
VAR_SEQ   158    170        ELLSRTSLETQKL -> VCAEARTKMGFPC (in isoform 5). VSP_009395
VAR_SEQ   171   1011        Missing (in isoform 5). VSP_009396
VAR_SEQ   233    263        Missing (in isoform 2 and isoform 4). VSP_009397
VAR_SEQ   302    302        D -> DENFKKKLKEKN (in isoform 2). VSP_009398
VAR_SEQ   349    349        K -> KKGK (in isoform 2). VSP_009399
VAR_SEQ   544    544        L -> LDRKRSASAPTL (in isoform 2). VSP_009400
VARIANT   148    148  1     V -> L (in dbSNP:rs2194816 [NCBI]). VAR_017758 
CONFLICT   308    308        M -> K (in Ref. 6; AAH46159). 
CONFLICT   453    453        C -> R (in Ref. 1; AAC26103). 
CONFLICT   553    553        E -> A (in Ref. 1; AAC26103). 
Sequence information
Length: 1011 AA [This is the length of the unprocessed precursor] Molecular weight: 114024 Da [This is the MW of the unprocessed precursor] CRC64: 20E30DD99ACD5A92 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH LVEDLRGLLE 

        70         80         90        100        110        120 
MMETDEKEGL RCQIPDSTAE TLVEWLQSQM TNGHLPGNGD VYQERLARLE NDKESLVLQV 

       130        140        150        160        170        180 
SVLTDQVEAQ GEKIRDLEFC LEEHREKVNA TEEMLQQELL SRTSLETQKL DLMAEISNLK 

       190        200        210        220        230        240 
LKLTAVEKDR LDYEDKFRDT EGLIQEINDL RLKVSEMDSE RLQYEKKLKS TKSLMAKLSS 

       250        260        270        280        290        300 
MKIKVGQMQY EKQRMEQKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGVEIVD 

       310        320        330        340        350        360 
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGKD GEYEELLNSS 

       370        380        390        400        410        420 
SISSLLDAQG FSDLEKSPSP TPVMGSPSCD PFNTSVPEEF HTTILQVSIP SLLPATVSME 

       430        440        450        460        470        480 
TSEKSKLTPK PETSFEENDG NIILGATVDT QLCDKLLTSS LQKSSSLGNL KKETSDGEKE 

       490        500        510        520        530        540 
TIQKTSEDRA PAESRPFGTL PPRPPGQDTS MDDNPFGTRK VRSSFGRGFF KIKSNKRTAS 

       550        560        570        580        590        600 
APNLAETEKE TAEHLDLAGA SSRPKDSQRN SPFQIPPPSP DSKKKSRGIM KLFGKLRRSQ 

       610        620        630        640        650        660 
STTFNPDDMS EPEFKRGGTR ATAGPRLGWS RDLGQSNSDL DMPFAKWTKE QVCNWLMEQG 

       670        680        690        700        710        720 
LGSYLNSGKH WIASGQTLLQ ASQQDLEKEL GIKHSLHRKK LQLALQALGS EEETNHGKLD 

       730        740        750        760        770        780 
FNWVTRWLDD IGLPQYKTQF DEGRVDGRML HYMTVDDLLS LKVVSVLHHL SIKRAIQVLR 

       790        800        810        820        830        840 
INNFEPNCLR RRPSDENTIA PSEVQKWTNH RVMEWLRSVD LAEYAPNLRG SGVHGGLMVL 

       850        860        870        880        890        900 
EPRFNVETMA QLLNIPPNKT LLRRHLATHF NLLIGAEAQH QKRDAMELPD YVLLTATAKV 

       910        920        930        940        950        960 
KPKKLAFSNF GNLRKKKQED GEEYVCPMEL GQASGSASKK GFKPGLDMRL YEEDDLDRLE 

       970        980        990       1000       1010 
QMEDSEGTVR QIGAFSEGIN NLTHMLKEDD MFKDFAARSP SASITDEDSN V 

Q86W92 in FASTA format

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