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UniProtKB/Swiss-Prot entry Q86CS2


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ATG1_DICDI
Primary accession number Q86CS2
Secondary accession number Q54D55
Integrated into Swiss-Prot on April 8, 2008
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    September 23, 2008 (Entry version 40)
Name and origin of the protein
Protein name Serine/threonine-protein kinase atg1
Synonyms EC 2.7.11.1
Autophagy-related protein 1
Gene name
Name: atg1
Synonyms: apg1
ORFNames: DDB_0185178
From
Dictyostelium discoideum (Slime mold) [TaxID: 44689] 
Taxonomy Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=AX3 / DH1;
DOI=10.1074/jbc.M212467200; PubMed=12626495 [NCBI, ExPASy, EBI, Israel, Japan]
Otto G.P., Wu M.Y., Kazgan N., Anderson O.R., Kessin R.H.;
"Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum.";
J. Biol. Chem. 278:17636-17645(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
DOI=10.1038/nature03481; PubMed=15875012 [NCBI, ExPASy, EBI, Israel, Japan]
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[3]
FUNCTION.
DOI=10.1074/jbc.M408924200; PubMed=15358773 [NCBI, ExPASy, EBI, Israel, Japan]
Kosta A., Roisin-Bouffay C., Luciani M.-F., Otto G.P., Kessin R.H., Golstein P.;
"Autophagy gene disruption reveals a non-vacuolar cell death pathway in Dictyostelium.";
J. Biol. Chem. 279:48404-48409(2004).
[4]
FUNCTION.
DOI=10.1038/sj.cdd.4401994; PubMed=16810325 [NCBI, ExPASy, EBI, Israel, Japan]
Laporte C., Kosta A., Klein G., Aubry L., Lam D., Tresse E., Luciani M.F., Golstein P.;
"A necrotic cell death model in a protist.";
Cell Death Differ. 14:266-274(2007).
[5]
FUNCTION.
DOI=10.1002/prot.21444; PubMed=17557329 [NCBI, ExPASy, EBI, Israel, Japan]
Miranda-Saavedra D., Barton G.J.;
"Classification and functional annotation of eukaryotic protein kinases.";
Proteins 68:893-914(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY191011; AAO39074.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AAFI02000190; EAL61174.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq XP_629641.1; -.
3D structure databases
HSSP Q07785; 1OB3. [HSSP ENTRY / PDB]
ModBase Q86CS2.
Organism-specific databases
dictyBase DDB0185178; atg1.
Ontologies
GO
GO:0034045; Cellular component: pre-autophagosomal structure membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.
Pfam PF00069; Pkinase; 1.
Pfam graphical view of domain structure.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00220; S_TKc; 1.
SMART graphical view of domain structure.
PROSITE PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q86CS2.
Genome annotation databases
GeneID 3386268; -.
KEGG ddi:DDB_0185178; -.
Other
ProtoNet Q86CS2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   668  668     Serine/threonine-protein kinase atg1. PRO_0000327584
DOMAIN   7   266  260     Protein kinase. 
NP_BIND   13    21  9     ATP (By similarity). 
COMPBIAS   283   301  19     Poly-Asn. 
COMPBIAS   309   348  40     Poly-Asn. 
COMPBIAS   370   386  17     Poly-Asn. 
COMPBIAS   441   470  30     Poly-Gln. 
ACT_SITE   135   135        Proton acceptor (By similarity). 
BINDING   36    36        ATP (By similarity). 
Sequence information
Length: 668 AA [This is the length of the unprocessed precursor] Molecular weight: 77175 Da [This is the MW of the unprocessed precursor] CRC64: 41B9D9DFD83A2D0C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKRVGDYILD KRIGWGAFAQ VYKGFSIKTN EPFAIKVVDV CRLADKNSKL TENLNYEIRI 

        70         80         90        100        110        120 
LKELSHTNIV RLYDVLNEET DPTFIYMIME CCEGGDFSKY IRTHKKLTEE KALYFMKQLA 

       130        140        150        160        170        180 
NGLKFLRQKQ IVHRDLKPQN LLLSDDSEHP ILKIGDFGFA KFIDPFSLSD TFCGSPLYMA 

       190        200        210        220        230        240 
PEILHRKNYT VKADLWSVGI ILYEMLVGEP AYNSGSVPDL LNQLQNKKIK LPSHISSDCQ 

       250        260        270        280        290        300 
NLIYSLLQID VEKRISWEDF FNHKWLNLNN NDSYKNNSGN YFNNNNINNN NNNNTNNNNN 

       310        320        330        340        350        360 
NISYPISINS NNTNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNYY NNNNSPPNVY 

       370        380        390        400        410        420 
HASSLPYDFN NNNNNNNSNN YNNNTNVPNS LPFAYNNNIY SSPTEAIPQP TTLNKSKSLE 

       430        440        450        460        470        480 
NTGNTIRAHP FKDDKKSTTI QQPQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ NRQLSNLSTD 

       490        500        510        520        530        540 
FERDLVILDG EELESMERVF NRAVAIAELG DLRQNEPLEC VPLYILALKL MKSKIPNDPS 

       550        560        570        580        590        600 
SSPDKFINTF TEYKRKLVHI FSTSNTSVKN QDHHSSFSPN RFIYENALEF GKKGAVEELY 

       610        620        630        640        650        660 
NNYPTSLQFY TDGTLLLEYL SSIVIDSDDQ EIIKKYLNAF EVRTQICKKN YENSKNTVLN 


TNSIQNNT 

Q86CS2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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