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UniProtKB/Swiss-Prot entry Q839C1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH1_ENTFA
Primary accession number Q839C1
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 42)
Name and origin of the protein
Protein name L-lactate dehydrogenase 1
Synonyms L-LDH 1
EC 1.1.1.27
Gene name
Name: ldh1
Synonyms: ldh-1
OrderedLocusNames: EF_0255
From
Enterococcus faecalis (Streptococcus faecalis) [TaxID: 1351] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=V583 / ATCC 700802;
DOI=10.1126/science.1080613; PubMed=12663927 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.";
Science 299:2071-2074(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016830; AAO80120.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_814049.1; -.
3D structure databases
HSSP P00344; 2LDB. [HSSP ENTRY / PDB]
SMR Q839C1; 3-320.
ModBase Q839C1.
Enzyme and pathway databases
BioCyc EFAE226185:EF_0255-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q839C1.
Genome annotation databases
GeneID 1199146; -.
GenomeReviews AE016830_GR; EF_0255.
KEGG efa:EF0255; -.
NMPDR fig|226185.1.peg.235; -.
TIGR EF_0255; -.
Phylogenomic databases
HOGENOM Q839C1; -.
Other
ProtoNet Q839C1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   327  327     L-lactate dehydrogenase 1. PRO_0000168343
NP_BIND   19    47  29     NAD (By similarity). 
ACT_SITE   182   182        Proton acceptor (By similarity). 
BINDING   95    95        Substrate (By similarity). 
BINDING   127   127        NAD or substrate (By similarity). 
BINDING   158   158        Substrate (By similarity). 
BINDING   236   236        Substrate (By similarity). 
MOD_RES   227   227        Phosphotyrosine (By similarity). 
Sequence information
Length: 327 AA [This is the length of the unprocessed precursor] Molecular weight: 35487 Da [This is the MW of the unprocessed precursor] CRC64: E7D6F6D13D0C07AB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTAAAGNKDH QKVILVGDGA VGSSYAFALV TQNIAQEVGI IDINVPKTEG DALDLSHALA 

        70         80         90        100        110        120 
FTSPKKIYAA TYDDCHDADL VVLTAGAPQK PGETRLDLVH KNLKINKEIV TTIVDSGFNG 

       130        140        150        160        170        180 
IFLVAANPVD ILTYSTWKFS GFPKERVIGS GTSLDSARFR QAIAELVDVD ARNVHAYILG 

       190        200        210        220        230        240 
EHGDTEFPVW SHANVAGLQI YEWVKNNPDV DEEAMVNLFF NVRDAAYTII EKKGATFYGI 

       250        260        270        280        290        300 
AVALARITKA ILNDENSVLP LSVYLEGEYG QNDIYIGAPA IINRQGVKQV IEIPLTDAEQ 

       310        320 
EKMEASASAL KEVIETAFAK FEAEEAK
Q839C1 in FASTA format

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