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UniProtKB/Swiss-Prot entry Q838C9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDH2_ENTFA
Primary accession number Q838C9
Secondary accession numbers None
Integrated into Swiss-Prot on June 21, 2004
Sequence was last modified on June 1, 2003 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 42)
Name and origin of the protein
Protein name L-lactate dehydrogenase 2
Synonyms L-LDH 2
EC 1.1.1.27
Gene name
Name: ldh2
Synonyms: ldh-2
OrderedLocusNames: EF_0641
From
Enterococcus faecalis (Streptococcus faecalis) [TaxID: 1351] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Enterococcaceae; Enterococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=V583 / ATCC 700802;
DOI=10.1126/science.1080613; PubMed=12663927 [NCBI, ExPASy, EBI, Israel, Japan]
Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R., Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C., Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M., Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
"Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.";
Science 299:2071-2074(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE016830; AAO80466.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_814395.1; -.
3D structure databases
HSSP P00344; 1LDB. [HSSP ENTRY / PDB]
ModBase Q838C9.
Enzyme and pathway databases
BioCyc EFAE226185:EF_0641-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00488; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
BLOCKS Q838C9.
Genome annotation databases
GeneID 1199542; -.
GenomeReviews AE016830_GR; EF_0641.
KEGG efa:EF0641; -.
NMPDR fig|226185.1.peg.581; -.
TIGR EF_0641; -.
Phylogenomic databases
HOGENOM Q838C9; -.
Other
ProtoNet Q838C9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; Oxidoreductase; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   317  317     L-lactate dehydrogenase 2. PRO_0000168344
NP_BIND   14    42  29     NAD (By similarity). 
ACT_SITE   178   178        Proton acceptor (By similarity). 
BINDING   91    91        Substrate (By similarity). 
BINDING   123   123        NAD or substrate (By similarity). 
BINDING   154   154        Substrate (By similarity). 
BINDING   232   232        Substrate (By similarity). 
MOD_RES   223   223        Phosphotyrosine (By similarity). 
Sequence information
Length: 317 AA [This is the length of the unprocessed precursor] Molecular weight: 34368 Da [This is the MW of the unprocessed precursor] CRC64: D4C27C58A7D55E5A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKVFNKKVAI IGTGFVGTSI AYSMINQGIA NELILVDIDK AKSEGEAIDL LDGVSWGQEN 

        70         80         90        100        110        120 
VNVWAGDYQD CQDADIVVIT AGANQKPGQS RLDLVSINAE IMKTIVNNIM KSGFDGILVI 

       130        140        150        160        170        180 
ASNPVDVLTY VAWQASGLPV SRVIGTGTTL DTTRFRKELS QRLAIDPRNV HGYIIGEHGD 

       190        200        210        220        230        240 
SEVAVWSHTM IGTKPILEIV DTTERLTSDD LPIISDKVKN TAYEIIDRKQ ATYYGIGMST 

       250        260        270        280        290        300 
ARIVKAILNN EQAILPVSAY LDGQYGQQDV FTGIPAVVGN QGVTDIIELN LNAAEKELFQ 

       310 
KSVTQLKQVM ASLQPNA
Q838C9 in FASTA format

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